SYSTEMS APPROACHES TO UNDERSTANDING THE ASSEMBLY OF MITOCHONDRIAL MACHINES

Grant number: 1140906 | Funding period: 2018 - 2021

Completed

Abstract

Mitochondria produce the energy for our bodies. Defects in this process cause mitochondrial disease, which affects at least 1/5000 people. Diagnosis is often inconclusive as we do not understand the function of many proteins important in mitochondrial energy production. State of the art CRISPR gene-editing tools will be coupled with advanced proteomics techniques to model different types of mitochondrial disease and identify the functions of new candidate disease genes.

Related publications (25)

University of Melbourne Researchers