INVESTIGATING PATHWAYS OF LIPOGLYCAN FORMATION IN THE BACTERIAL CELL WALL

Grant number: DP180102463 | Funding period: 2018 - 2020

Completed

Abstract

This project aims to investigate how the complex cell walls of Mycobacteria and Corynebacteria are assembled. The project will utilise a combination of genetic, biochemical and advanced analytical approaches to investigate individual steps in the synthesis of key cell wall components and understand how the assembly of these components is coordinated with bacterial growth. Important outcomes of this research will be detailed information on processes that regulate the growth of bacteria with important biotechnology, veterinary and medical significance, as well as information on mechanisms of cell wall synthesis that may be conserved in all bacteria.

Related publications (2)

Crystal structure of the putative cell-wall lipoglycan biosynthesis protein LmcA from Mycobacterium smegmatis.

Onisha Patel, Rajini Brammananth, Weiwen Dai, Santosh Panjikar, Ross L Coppel, Isabelle S Lucet, Paul K Crellin

2022-04-01

The bacterial genus Mycobacterium includes important pathogens, most notably M. tuberculosis, which infects one-quarter of the ent..

Cellular and Structural Basis of Synthesis of the Unique Intermediate Dehydro-F-420-0 in Mycobacteria

Rhys Grinter, Blair Ney, Rajini Brammananth, Christopher K Barlow, Paul RF Cordero, David L Gillett, Thierry Izore, Max J Cryle, Liam K Harold, Gregory M Cook, George Taiaroa, Deborah A Williamson, Andrew C Warden, John G Oakeshott, Matthew C Taylor, Paul K Crellin, Colin J Jackson, Ralf B Schittenhelm, Ross L Coppel, Chris Greening

2020-05-01

F420 is a low-potential redox cofactor used by diverse bacteria and archaea. In mycobacteria, this cofactor has multiple roles, in..

University of Melbourne Researchers

Malcolm McConville Biochemistry and Pharmacology