Lipid Metabolism in Health and Disease

Diabetic heart shows preferential secretion of inner mitochondrial membrane proteins in the presence of mitochondrial oxidative stress

PM Miotto, J Bayliss, G Fidelito, JR Bell, LMD Delbridge, MJ Watt, MK Montgomery

2025-12-01

Heart disease, including diabetic cardiomyopathy, is a leading cause of mortality in patients with type 2 diabetes (T2D). Defects ..

Lipid-metabolism-focused CRISPR screens identify enzymes of the mevalonate pathway as essential for prostate cancer growth

G Fidelito, I Todorovski, L Cluse, SJ Vervoort, RA Taylor, MJ Watt

2025-04-22

Dysregulated lipid metabolism plays an important role in prostate cancer, although the understanding of the essential regulatory p..

Pilot investigations into the mechanistic basis for adverse effects of glucocorticoids in dysferlinopathy

Erin M Lloyd, Rachael C Crew, Vanessa R Haynes, Robert B White, Peter J Mark, Connie Jackaman, John M Papadimitriou, Gavin J Pinniger, Robyn M Murphy, Matthew J Watt, Miranda D Grounds

2024-08-09

BACKGROUND: Dysferlinopathies are a clinically heterogeneous group of muscular dystrophies caused by gene mutations resulting in d..

Mouse strain-dependent variation in metabolic associated fatty liver disease (MAFLD): a comprehensive resource tool for pre-clinical studies

H Karimkhanloo, SN Keenan, J Bayliss, W De Nardo, PM Miotto, CJ Devereux, S Nie, NA Williamson, A Ryan, MJ Watt, MK Montgomery

2023-12-01

Non-alcoholic steatohepatitis (NASH), characterized as the joint presence of steatosis, hepatocellular ballooning and lobular infl..

Multi-substrate Metabolic Tracing Reveals Marked Heterogeneity and Dependency on Fatty Acid Metabolism in Human Prostate Cancer

G Fidelito, DP De Souza, B Niranjan, W De Nardo, S Keerthikumar, K Brown, RA Taylor, MJ Watt

2023-04-01

Cancer cells undergo metabolic reprogramming to meet tricarboxylic acid cycle through transaminase reactions before increased bioe..

Investigating dual inhibition of ACC and CD36 for the treatment of nonalcoholic fatty liver disease in mice

CJ Devereux, J Bayliss, SN Keenan, MK Montgomery, MJ Watt

2023-02-01

Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide. Dysregulation in hepatic lipid metabo..

Deep proteomic profiling unveils arylsulfatase A as a non-alcoholic steatohepatitis inducible hepatokine and regulator of glycemic control

MK Montgomery, J Bayliss, S Nie, W De Nardo, SN Keenan, PM Miotto, H Karimkhanloo, C Huang, RB Schittenhelm, AS Don, A Ryan, NA Williamson, GJ Ooi, WA Brown, PR Burton, BL Parker, MJ Watt

2022-12-01

Non-alcoholic steatohepatitis (NASH) and type 2 diabetes are closely linked, yet the pathophysiological mechanisms underpinning th..

Personalized Medicine for Prostate Cancer: Is Targeting Metabolism a Reality?

G Fidelito, MJ Watt, RA Taylor

2022-01-21

Prostate cancer invokes major shifts in gene transcription and metabolic signaling to mediate alterations in nutrient acquisition ..

Hepatic lipidomic remodeling in severe obesity manifests with steatosis and does not evolve with non-alcoholic steatohepatitis

GJ Ooi, PJ Meikle, K Huynh, A Earnest, SK Roberts, W Kemp, BL Parker, W Brown, P Burton, MJ Watt

2021-09-01

Backgrounds & Aims: Obesity often leads to non-alcoholic fatty liver disease (NAFLD), which can progress from simple steatosis (no..

Proteome analysis of human adipocytes identifies depot-specific heterogeneity at metabolic control points

A Raajendiran, C Krisp, DP de Souza, G Ooi, PR Burton, RA Taylor, MP Molloy, MJ Watt

2021-06-01

Adipose tissue is a primary regulator of energy balance and metabolism. The distribution of adipose tissue depots is of clinical i..

Perilipin 5 S155 phosphorylation by PKA is required for the control of hepatic lipid metabolism and glycemic control

SN Keenan, W De Nardo, J ou, RB Schittenhelm, MK Montgomery, JG Granneman, E Hinde, MJ Watt

2021-01-01

Perilipin 5 (PLIN5) is a lipid-dropletassociated protein that coordinates intracellular lipolysis in highly oxidative tissues and ..

Long Chain Fatty Acids Differentially Regulate Sub-populations of Arcuate POMC and NPY Neurons

NJ Michael, MJ Watt

2020-12-15

Long chain fatty acids (LCFAs) have been suggested to influence the activity of hypothalamic neurons, however, limited studies hav..

Impact of human visceral and glutealfemoral adipose tissue transplant on glycemic control in a mouse model of diet-induced obesity

T Tsiloulis, A Raajendiran, SN Keenan, G Ooi, RA Taylor, P Burton, MJ Watt

2020-09-01

Regional distribution of adipose tissue is an important factor in conferring cardiometabolic risk and obesity-related morbidity. W..

Early intervention exercise training does not delay prostate cancer progression in Pten−/− mice

RA Taylor, SG Farrelly, AK Clark, MJ Watt

2020-08-01

Background: There is convincing evidence that men with advanced prostate cancer experience improved quality of life as a result of..

Molecular regulators of lipid metabolism in the intestine – Underestimated therapeutic targets for obesity?

M Dávalos-Salas, JM Mariadason, MJ Watt, MK Montgomery

2020-08-01

The incidence of obesity and type 2 diabetes continues to rise across the globe necessitating the need to identify new therapeutic..

Inter-organelle Communication in the Pathogenesis of Mitochondrial Dysfunction and Insulin Resistance

SN Keenan, MJ Watt, MK Montgomery

2020-06-01

Purpose of Review: Impairments in mitochondrial function in patients with insulin resistance and type 2 diabetes have been dispute..

A Neural basis for Octanoic acid regulation of energy balance

VR Haynes, NJ Michael, M van den Top, FY Zhao, RD Brown, D De Souza, GT Dodd, D Spanswick, MJ Watt

2020-04-01

Objectives: Nutrient sensing by hypothalamic neurons is critical for the regulation of food intake and energy expenditure. We aime..

SMOC1 is a glucose-responsive hepatokine and therapeutic target for glycemic control

MK Montgomery, J Bayliss, C Devereux, A Bezawork-Geleta, D Roberts, C Huang, RB Schittenhelm, A Ryan, SL Townley, LA Selth, TJ Biden, GR Steinberg, D Samocha-Bonet, RCR Meex, MJ Watt

2020-01-01

Intertissue communication is a fundamental feature of metabolic regulation, and the liver is central to this process. We have iden..

Deletion of intestinal Hdac3 remodels the lipidome of enterocytes and protects mice from diet-induced obesity

M Dávalos-Salas, MK Montgomery, CM Reehorst, R Nightingale, I Ng, H Anderton, S Al-Obaidi, A Lesmana, CM Scott, P Ioannidis, H Kalra, S Keerthikumar, L Tögel, A Rigopoulos, SJ Gong, DS Williams, P Yoganantharaja, K Bell-Anderson, S Mathivanan, Y Gibert

2019-12-01

Histone deacetylase 3 (Hdac3) regulates the expression of lipid metabolism genes in multiple tissues, however its role in regulati..

The role of Ap2a2 in PPARα-mediated regulation of lipolysis in adipose tissue

MK Montgomery, J Bayliss, S Keenan, S Rhost, SB Ting, MJ Watt

2019-12-01

Adipose tissue plays a major role in the regulation of systemic metabolic homeostasis, with the AP2 adaptor complex being importan..

The Liver as an Endocrine Organ - Linking NAFLD and Insulin Resistance

MJ Watt, PM Miotto, W De Nardo, MK Montgomery

2019-05-10

The liver is a dynamic organ that plays critical roles in many physiological processes, including the regulation of systemic gluco..

Identification of Metabolically Distinct Adipocyte Progenitor Cells in Human Adipose Tissues

A Raajendiran, G Ooi, J Bayliss, PE O'Brien, RB Schittenhelm, AK Clark, RA Taylor, MS Rodeheffer, PR Burton, MJ Watt

2019-04-30

Adipocyte progenitor cells (APCs) provide the reservoir of regenerative cells to produce new adipocytes, although their identity i..

Impact of lipotoxicity on tissue “cross talk” and metabolic regulation

MK Montgomery, W De Nardo, MJ Watt

2019-03-01

Obesity-associated comorbidities include non-alcoholic fatty liver disease, Type 2 diabetes, and cardiovascular disease. These dis..

Perilipin 5 deletion in hepatocytes remodels lipid metabolism and causes hepatic insulin resistance in mice

MK Montgomery, MJ Watt, SN Keenan, RC Meex, JCY Lo, A Ryan, S Nie

2019-03-01

Defects in hepatic lipid metabolism cause nonalcoholic fatty liver disease and insulin resistance, and these pathologies are close..

Suppressing fatty acid uptake has therapeutic effects in preclinical models of prostate cancer

MJ Watt, AK Clark, LA Selth, VR Haynes, N Lister, R Rebello, LH Porter, B Niranjan, ST Whitby, J Lo, C Huang, RB Schittenhelm, KE Anderson, L Furic, PR Wijayaratne, M Matzaris, MK Montgomery, M Papargiris, S Norden, M Febbraio

2019-02-06

Metabolism alterations are hallmarks of cancer, but the involvement of lipid metabolism in disease progression is unclear. We inve..

Dysferlin deficiency alters lipid metabolism and remodels the skeletal muscle lipidome in mice

VR Haynes, SN Keenan, J Bayliss, EM Lloyd, PJ Meikle, MD Grounds, MJ Watt

2019-01-01

Defects in the gene coding for dysferlin, a membrane-associated protein, affect many tissues, including skeletal muscles, with a r..

The Influence of Aerobic Exercise on Hippocampal Integrity and Function: Preliminary Findings of a Multi-Modal Imaging Analysis.

Lauren Den Ouden, Aaron Kandola, Chao Suo, Joshua Hendrikse, Ricardo JS Costa, Matthew J Watt, Valentina Lorenzetti, Yann Chye, Linden Parkes, Kristina Sabaroedin, Murat Yücel

2018-12-26

Aerobic exercise (AE) interventions represent promising therapeutic approaches in disorders that compromise hippocampal integrity,..

Absence of renal hypoxia in the subacute phase of severe renal ischemia-reperfusion injury

CPC Ow, JP Ngo, MM Ullah, G Barsha, RC Meex, MJ Watt, LM Hilliard, MP Koeners, RG Evans

2018-10-29

Tissue hypoxia has been proposed as an important event in renal ischemia-reperfusion injury (IRI), particularly during the period ..

Insights into the neurochemical signature of the Innervation of Beige Fat

A Stefanidis, NM Wiedmann, S Tyagi, AM Allen, MJ Watt, BJ Oldfield

2018-05-01

Objective: The potential for brown adipose tissue (BAT) to be targeted as a therapeutic option to combat obesity has been heighten..

No evidence of white adipocyte browning after endurance exercise training in obese men

T Tsiloulis, AL Carey, J Bayliss, B Canny, RCR Meex, MJ Watt

2018-04-01

Background/Objectives:The phenomenon of adipocyte 'beiging' involves the conversion of non-classic brown adipocytes to brown-like ..

Perilipin 5 deletion unmasks an endoplasmic reticulum Stress-Fibroblast growth factor 21 axis in skeletal muscle

MK Montgomery, R Mokhtar, J Bayliss, HC Parkington, VM Suturin, CR Bruce, MJ Watt

2018-04-01

Lipid droplets (LDs) are critical for the regulation of lipid metabolism, and dysregulated lipid metabolism contributes to the pat..

AgRP Neurons Require Carnitine Acetyltransferase to Regulate Metabolic Flexibility and Peripheral Nutrient Partitioning

A Reichenbach, R Stark, M Mequinion, RRG Denis, JF Goularte, RE Clarke, SH Lockie, MB Lemus, GM Kowalski, CR Bruce, C Huang, RB Schittenhelm, RL Mynatt, BJ Oldfield, MJ Watt, S Luquet, ZB Andrews

2018-02-13

AgRP neurons control peripheral substrate utilization and nutrient partitioning during conditions of energy deficit and nutrient r..

Mitochondrial dysfunction-related lipid changes occur in nonalcoholic fatty liver disease progression

KY Peng, MJ Watt, S Rensen, J Willem Greve, K Huynh, KS Jayawardana, PJ Meikle, RCR Meex

2018-01-01

Nonalcoholic fatty liver disease (NAFLD) comprises fat-accumulating conditions within hepatocytes that can cause severe liver dama..

Increased liver AGEs induce hepatic injury mediated through an OST48 pathway

A Zhuang, FY Yap, C Bruce, C Leung, MR Plan, MA Sullivan, C Herath, D McCarthy, KC Sourris, P Kantharidis, MT Coughlan, MA Febbraio, MP Hodson, MJ Watt, P Angus, BL Schulz, JM Forbes

2017-12-01

The protein oligosaccharyltransferase-48 (OST48) is integral to protein N-glycosylation in the endoplasmic reticulum (ER) but is a..

Triglyceride metabolism in exercising muscle

MJ Watt, Y Cheng

2017-10-01

Triglycerides are stored within lipid droplets in skeletal muscle and can be hydrolyzed to produce fatty acids for energy producti..

Hepatokines: Linking nonalcoholic fatty liver disease and insulin resistance

RCR Meex, MJ Watt

2017-09-01

Hepatic steatosis is an underlying feature of nonalcoholic fatty liver disease (NAFLD), which is the most common form of liver dis..

Prevention of the adverse effects of olanzapine on lipid metabolism with the antiepileptic zonisamide

A Stefanidis, MJ Watt, MA Cowley, BJ Oldfield

2017-09-01

Background Atypical antipsychotic drugs, particularly olanzapine, represent a mainstay in the treatment of psychoses; however, the..

Specific targeting of TGF-β family ligands demonstrates distinct roles in the regulation of muscle mass in health and disease

JL Chen, KL Walton, A Hagg, TD Colgan, K Johnson, H Qian, P Gregorevic, CA Harrison

2017-06-27

The transforming growth factor-β (TGF-β) network of ligands and intracellular signaling proteins is a subject of intense interest ..

Impact of endurance exercise training on adipocyte microRNA expression in overweight men

T Tsiloulis, J Pike, D Powell, FJ Rossello, BJ Canny, RCR Meex, MJ Watt

2017-01-01

Adipocytes are major regulators of metabolism, and endurance exercise training improves adipocyte function; however, the molecular..

RABL2 is required for hepatic fatty acid homeostasis and its dysfunction leads to steatosis and a diabetes-like state

JCY Lo, AE O'Connor, ZB Andrews, C Lo, T Tiganis, MJ Watt, MK O'Bryan

2016-12-01

Fatty liver, or hepatic steatosis, is an alarmingly common pathology in western societies, in large part because if left unheeded,..

Perilipin 5 is dispensable for normal substrate metabolism and in the adaptation of skeletal muscle to exercise training

RAM Mohktar, MK Montgomery, RM Murphy, MJ Watt

2016-07-01

Cytoplasmic lipid droplets provide a reservoir for triglyceride storage and are a central hub for fatty acid trafficking in cells...

Central Administration of the Ciliary Neurotrophic Factor Analogue, Axokine, Does Not Play a Role in Long-Term Energy Homeostasis in Adult Mice

ML Borg, A Reichenbach, M Lemus, BJ Oldfield, ZB Andrews, MJ Watt

2016-05-01

Background/Aims: Ciliary neurotrophic factor (CNTF) exerts powerful anorectic effects and has been suggested to regulate long-term..

ATGL-mediated triglyceride turnover and the regulation of mitochondrial capacity in skeletal muscle

RCR Meex, AJ Hoy, RM Mason, SD Martin, SL McGee, CR Bruce, MJ Watt

2015-06-01

Emerging evidence indicates that skeletal muscle lipid droplets are an important control point for intracellular lipid homeostasis..

Unraveling the roles of PLIN5: Linking cell biology to physiology

RR Mason, MJ Watt

2015-03-01

The discovery of perilipin (PLIN) 1 provided a major conceptual shift in the understanding of adipose tissue lipolysis and generat..

Fetuin B Is a Secreted Hepatocyte Factor Linking Steatosis to Impaired Glucose Metabolism

RC Meex, AJ Hoy, A Morris, RD Brown, JCY Lo, M Burke, RJA Goode, BA Kingwell, MJ Kraakman, MA Febbraio, JW Greve, SS Rensen, MP Molloy, GI Lancaster, CR Bruce, MJ Watt

2015-01-01

Liver steatosis is associated with the development of insulin resistance and the pathogenesis of type 2 diabetes. We tested the hy..