LIPID METABOLISM IN HEALTH AND DISEASE
Grant number: 1077703 | Funding period: 2018 - 2019
Obesity is associated with type 2 diabetes, fatty liver disease, cardiovascular disease and cancer. These inter-related diseases reduce life expectancy and their treatments come at an enormous financial cost. The overriding aim of this work is to understand the molecular and cellular regulation of lipid metabolism in skeletal muscle, liver and adipose tissue, and how this impacts endocrine function to affect the pathogenesis of types 2 diabetes and prostate cancer.
Related publications (33)
Hepatic lipidomic remodeling in severe obesity manifests with steatosis and does not evolve with non-alcoholic steatohepatitis
Geraldine J Ooi, Peter J Meikle, Kevin Huynh, Wendy Brown, Paul Burton, Matthew J Watt
BACKGROUNDS & AIMS: Obesity often leads to non-alcoholic fatty liver disease (NAFLD), which can progress from simple steatosis (no..
Proteome analysis of human adipocytes identifies depot-specific heterogeneity at metabolic control points
Arthe Raajendiran, Christoph Krisp, David P De Souza, Geraldine Ooi, Paul R Burton, Renea A Taylor, Mark P Molloy, Matthew J Watt
Adipose tissue is a primary regulator of energy balance and metabolism. The distribution of adipose tissue depots is of clinical i..
Perilipin 5 S155 phosphorylation by PKA is required for the control of hepatic lipid metabolism and glycemic control
Stacey N Keenan, William De Nardo, Jieqiong Lou, Ralf B Schittenhelm, Magdalene K Montgomery, James G Granneman, Elizabeth Hinde, Matthew J Watt
Perilipin 5 (PLIN5) is a lipid-droplet-associated protein that coordinates intracellular lipolysis in highly oxidative tissues and..
SMOC1 is a glucose-responsive hepatokine and therapeutic target for glycemic control
Magdalene K Montgomery, Jacqueline Bayliss, Camille Devereux, Ayenachew Bezawork-Geleta, David Roberts, Cheng Huang, Ralf B Schittenhelm, Andrew Ryan, Scott L Townley, Luke A Selth, Trevor J Biden, Gregory R Steinberg, Dorit Samocha-Bonet, Ruth CR Meex, Matthew J Watt
Intertissue communication is a fundamental feature of metabolic regulation, and the liver is central to this process. We have iden..
Impact of human visceral and glutealfemoral adipose tissue transplant on glycemic control in a mouse model of diet-induced obesity
Thomas Tsiloulis, Arthe Raajendiran, Stacey N Keenan, Geraldine Ooi, Renea A Taylor, Paul Burton, Matthew J Watt
Regional distribution of adipose tissue is an important factor in conferring cardiometabolic risk and obesity-related morbidity. W..
Molecular regulators of lipid metabolism in the intestine - Underestimated therapeutic targets for obesity?
Mercedes Davalos-Salas, John M Mariadason, Matthew J Watt, Magdalene K Montgomery
The incidence of obesity and type 2 diabetes continues to rise across the globe necessitating the need to identify new therapeutic..
Early intervention exercise training does not delay prostate cancer progression in Pten(-/-) mice
Renea A Taylor, Simon G Farrelly, Ashlee K Clark, Matthew J Watt
BACKGROUND: There is convincing evidence that men with advanced prostate cancer experience improved quality of life as a result of..
Inter-organelle Communication in the Pathogenesis of Mitochondrial Dysfunction and Insulin Resistance
Stacey N Keenan, Matthew J Watt, Magdalene K Montgomery
PURPOSE OF REVIEW: Impairments in mitochondrial function in patients with insulin resistance and type 2 diabetes have been dispute..
A Neural basis for Octanoic acid regulation of energy balance
Vanessa R Haynes, Natalie J Michael, Marco van den Top, Fei-Yue Zhao, Russell D Brown, David De Souza, Garron T Dodd, David Spanswick, Matthew J Watt
OBJECTIVES: Nutrient sensing by hypothalamic neurons is critical for the regulation of food intake and energy expenditure. We aime..
Deletion of intestinal Hdac3 remodels the lipidome of enterocytes and protects mice from diet-induced obesity
Mercedes Davalos-Salas, Magdalene K Montgomery, Camilla M Reehorst, Rebecca Nightingale, Irvin Ng, Holly Anderton, Sheren Al-Obaidi, Analia Lesmana, Cameron M Scott, Paul Ioannidis, Hina Kalra, Shivakumar Keerthikumar, Lars Togel, Angela Rigopoulos, Sylvia J Gong, David S Williams, Prusoth Yoganantharaja, Kim Bell-Anderson, Suresh Mathivanan, Yann Gibert
Histone deacetylase 3 (Hdac3) regulates the expression of lipid metabolism genes in multiple tissues, however its role in regulati..
Dysferlin deficiency alters lipid metabolism and remodels the skeletal muscle lipidome in mice[S]
Vanessa R Haynes, Stacey N Keenan, Jackie Bayliss, Erin M Lloyd, Peter Meikle, Miranda D Grounds, Matthew J Watt
Defects in the gene coding for dysferlin, a membrane-associated protein, affect many tissues, including skeletal muscles, with a r..
Identification of Metabolically Distinct Adipocyte Progenitor Cells in Human Adipose Tissues
Arthe Raajendiran, Geraldine Ooi, Jackie Bayliss, Paul E O'Brien, Ralf B Schittenhelm, Ashlee K Clark, Renea A Taylor, Matthew S Rodeheffer, Paul R Burton, Matthew J Watt
Adipocyte progenitor cells (APCs) provide the reservoir of regenerative cells to produce new adipocytes, although their identity i..
Perilipin 5 Deletion in Hepatocytes Remodels Lipid Metabolism and Causes Hepatic Insulin Resistance in Mice
Stacey N Keenan, Ruth C Meex, Jennifer CY Lo, Andrew Ryan, Shuai Nie, Magdalene K Montgomery, Matthew J Watt
Defects in hepatic lipid metabolism cause nonalcoholic fatty liver disease and insulin resistance, and these pathologies are close..
Suppressing fatty acid uptake has therapeutic effects in preclinical models of prostate cancer
Matthew J Watt, Ashlee K Clark, Luke A Selth, Vanessa R Haynes, Natalie Lister, Richard Rebello, Laura H Porter, Birunthi Niranjan, Sarah T Whitby, Jennifer Lo, Cheng Huang, Ralf B Schittenhelm, Kimberley E Anderson, Luc Furic, Poornima R Wijayaratne, Maria Matzaris, Magdalene K Montgomery, Melissa Papargiris, Sam Norden, Maria Febbraio
Metabolism alterations are hallmarks of cancer, but the involvement of lipid metabolism in disease progression is unclear. We inve..
The Influence of Aerobic Exercise on Hippocampal Integrity and Function: Preliminary Findings of a Multi-Modal Imaging Analysis.
Lauren Den Ouden, Aaron Kandola, Chao Suo, Joshua Hendrikse, Ricardo JS Costa, Matthew J Watt, Valentina Lorenzetti, Yann Chye, Linden Parkes, Kristina Sabaroedin, Murat Yücel
Aerobic exercise (AE) interventions represent promising therapeutic approaches in disorders that compromise hippocampal integrity,..
Absence of renal hypoxia in the subacute phase of severe renal ischemia-reperfusion injury.
Connie PC Ow, Jennifer P Ngo, Md Mahbub Ullah, Giannie Barsha, Ruth C Meex, Matthew J Watt, Lucinda M Hilliard, Maarten P Koeners, Roger G Evans
Tissue hypoxia has been proposed as an important event in renal ischemia-reperfusion injury (IRI), particularly during the period ..
Mitochondrial dysfunction-related lipid changes occur in nonalcoholic fatty liver disease progression
Kang-Yu Peng, Matthew J Watt, Sander Rensen, Jan Willem Greve, Kevin Huynh, Kaushala S Jayawardana, Peter J Meikle, Ruth CR Meex
Nonalcoholic fatty liver disease (NAFLD) comprises fat-accumulating conditions within hepatocytes that can cause severe liver dama..
Insights into the neurochemical signature of the Innervation of Beige Fat
Aneta Stefanidis, Nicole M Wiedmann, Sonika Tyagi, Andrew M Allen, Matthew J Watt, Brian J Oldfield
OBJECTIVE: The potential for brown adipose tissue (BAT) to be targeted as a therapeutic option to combat obesity has been heighten..
Perilipin 5 Deletion Unmasks an Endoplasmic Reticulum Stress-Fibroblast Growth Factor 21 Axis in Skeletal Muscle
Magdalene K Montgomery, Ruzaidi Mokhtar, Jacqueline Bayliss, Helena C Parkington, Victor M Suturin, Clinton R Bruce, Matthew J Watt
Lipid droplets (LDs) are critical for the regulation of lipid metabolism, and dysregulated lipid metabolism contributes to the pat..
AgRP Neurons Require Carnitine Acetyltransferase to Regulate Metabolic Flexibility and Peripheral Nutrient Partitioning.
Alex Reichenbach, Romana Stark, Mathieu Mequinion, Raphael RG Denis, Jeferson F Goularte, Rachel E Clarke, Sarah H Lockie, Moyra B Lemus, Greg M Kowalski, Clinton R Bruce, Cheng Huang, Ralf B Schittenhelm, Randall L Mynatt, Brian J Oldfield, Matthew J Watt, Serge Luquet, Zane B Andrews
AgRP neurons control peripheral substrate utilization and nutrient partitioning during conditions of energy deficit and nutrient r..
Increased liver AGEs induce hepatic injury mediated through an OST48 pathway
Aowen Zhuang, Felicia Yt Yap, Clinton Bruce, Chris Leung, Manuel R Plan, Mitchell A Sullivan, Chandana Herath, Domenica McCarthy, Karly C Sourris, Phillip Kantharidis, Melinda T Coughlan, Mark A Febbraio, Mark P Hodson, Matthew J Watt, Peter Angus, Benjamin L Schulz, Josephine M Forbes
The protein oligosaccharyltransferase-48 (OST48) is integral to protein N-glycosylation in the endoplasmic reticulum (ER) but is a..
Specific targeting of TGF-beta family ligands demonstrates distinct roles in the regulation of muscle mass in health and disease
Justin L Chen, Kelly L Walton, Adam Hagg, Timothy D Colgan, Katharine Johnson, Hongwei Qian, Paul Gregorevic, Craig A Harrison
The transforming growth factor-β (TGF-β) network of ligands and intracellular signaling proteins is a subject of intense interest ..
Impact of endurance exercise training on adipocyte microRNA expression in overweight men
Thomas Tsiloulis, Joshua Pike, David Powell, Fernando J Rossello, Benedict J Canny, Ruth CR Meex, Matthew J Watt
Adipocytes are major regulators of metabolism, and endurance exercise training improves adipocyte function; however, the molecular..
Perilipin 5 is dispensable for normal substrate metabolism and in the adaptation of skeletal muscle to exercise training
Ruzaidi AM Mohktar, Magda K Montgomery, Robyn M Murphy, Matthew J Watt
Cytoplasmic lipid droplets provide a reservoir for triglyceride storage and are a central hub for fatty acid trafficking in cells...
Fetuin B Is a Secreted Hepatocyte Factor Linking Steatosis to Impaired Glucose Metabolism
Ruth C Meex, Andrew J Hoy, Alexander Morris, Russell D Brown, Jennifer CY Lo, Melissa Burke, Robert JA Goode, Bronwyn A Kingwell, Michael J Kraakman, Mark A Febbraio, Jan Willem Greve, Sander S Rensen, Mark P Molloy, Graeme I Lancaster, Clinton R Bruce, Matthew J Watt
Liver steatosis is associated with the development of insulin resistance and the pathogenesis of type 2 diabetes. We tested the hy..
ATGL-mediated triglyceride turnover and the regulation of mitochondrial capacity in skeletal muscle
Ruth CR Meex, Andrew J Hoy, Rachael M Mason, Sheree D Martin, Sean L McGee, Clinton R Bruce, Matthew J Watt
Emerging evidence indicates that skeletal muscle lipid droplets are an important control point for intracellular lipid homeostasis..