LIPID METABOLISM IN HEALTH AND DISEASE

Hepatic lipidomic remodeling in severe obesity manifests with steatosis and does not evolve with non-alcoholic steatohepatitis

Geraldine J Ooi, Peter J Meikle, Kevin Huynh, Wendy Brown, Paul Burton, Matthew J Watt

2021-09-01

BACKGROUNDS & AIMS: Obesity often leads to non-alcoholic fatty liver disease (NAFLD), which can progress from simple steatosis (no..

Proteome analysis of human adipocytes identifies depot-specific heterogeneity at metabolic control points

Arthe Raajendiran, Christoph Krisp, David P De Souza, Geraldine Ooi, Paul R Burton, Renea A Taylor, Mark P Molloy, Matthew J Watt

2021-06-01

Adipose tissue is a primary regulator of energy balance and metabolism. The distribution of adipose tissue depots is of clinical i..

Perilipin 5 S155 phosphorylation by PKA is required for the control of hepatic lipid metabolism and glycemic control

Stacey N Keenan, William De Nardo, Jieqiong Lou, Ralf B Schittenhelm, Magdalene K Montgomery, James G Granneman, Elizabeth Hinde, Matthew J Watt

2021-01-01

Perilipin 5 (PLIN5) is a lipid-droplet-associated protein that coordinates intracellular lipolysis in highly oxidative tissues and..

Long Chain Fatty Acids Differentially Regulate Sub-populations of Arcuate POMC and NPY Neurons

Natalie J Michael, Matthew J Watt

2020-12-15

Long chain fatty acids (LCFAs) have been suggested to influence the activity of hypothalamic neurons, however, limited studies hav..

SMOC1 is a glucose-responsive hepatokine and therapeutic target for glycemic control

Magdalene K Montgomery, Jacqueline Bayliss, Camille Devereux, Ayenachew Bezawork-Geleta, David Roberts, Cheng Huang, Ralf B Schittenhelm, Andrew Ryan, Scott L Townley, Luke A Selth, Trevor J Biden, Gregory R Steinberg, Dorit Samocha-Bonet, Ruth CR Meex, Matthew J Watt

2020-09-02

Intertissue communication is a fundamental feature of metabolic regulation, and the liver is central to this process. We have iden..

Impact of human visceral and glutealfemoral adipose tissue transplant on glycemic control in a mouse model of diet-induced obesity

Thomas Tsiloulis, Arthe Raajendiran, Stacey N Keenan, Geraldine Ooi, Renea A Taylor, Paul Burton, Matthew J Watt

2020-09-01

Regional distribution of adipose tissue is an important factor in conferring cardiometabolic risk and obesity-related morbidity. W..

Molecular regulators of lipid metabolism in the intestine - Underestimated therapeutic targets for obesity?

Mercedes Davalos-Salas, John M Mariadason, Matthew J Watt, Magdalene K Montgomery

2020-08-01

The incidence of obesity and type 2 diabetes continues to rise across the globe necessitating the need to identify new therapeutic..

Early intervention exercise training does not delay prostate cancer progression in Pten(-/-) mice

Renea A Taylor, Simon G Farrelly, Ashlee K Clark, Matthew J Watt

2020-06-10

BACKGROUND: There is convincing evidence that men with advanced prostate cancer experience improved quality of life as a result of..

Inter-organelle Communication in the Pathogenesis of Mitochondrial Dysfunction and Insulin Resistance

Stacey N Keenan, Matthew J Watt, Magdalene K Montgomery

2020-04-18

PURPOSE OF REVIEW: Impairments in mitochondrial function in patients with insulin resistance and type 2 diabetes have been dispute..

A Neural basis for Octanoic acid regulation of energy balance

Vanessa R Haynes, Natalie J Michael, Marco van den Top, Fei-Yue Zhao, Russell D Brown, David De Souza, Garron T Dodd, David Spanswick, Matthew J Watt

2020-04-01

OBJECTIVES: Nutrient sensing by hypothalamic neurons is critical for the regulation of food intake and energy expenditure. We aime..

Deletion of intestinal Hdac3 remodels the lipidome of enterocytes and protects mice from diet-induced obesity

Mercedes Davalos-Salas, Magdalene K Montgomery, Camilla M Reehorst, Rebecca Nightingale, Irvin Ng, Holly Anderton, Sheren Al-Obaidi, Analia Lesmana, Cameron M Scott, Paul Ioannidis, Hina Kalra, Shivakumar Keerthikumar, Lars Togel, Angela Rigopoulos, Sylvia J Gong, David S Williams, Prusoth Yoganantharaja, Kim Bell-Anderson, Suresh Mathivanan, Yann Gibert

2019-11-22

Histone deacetylase 3 (Hdac3) regulates the expression of lipid metabolism genes in multiple tissues, however its role in regulati..

The Liver as an Endocrine Organ-Linking NAFLD and Insulin Resistance

Matthew J Watt, Paula M Miotto, William De Nardo, Magdalene K Montgomery

2019-10-01

The liver is a dynamic organ that plays critical roles in many physiological processes, including the regulation of systemic gluco..

Dysferlin deficiency alters lipid metabolism and remodels the skeletal muscle lipidome in mice[S]

Vanessa R Haynes, Stacey N Keenan, Jackie Bayliss, Erin M Lloyd, Peter Meikle, Miranda D Grounds, Matthew J Watt

2019-08-01

Defects in the gene coding for dysferlin, a membrane-associated protein, affect many tissues, including skeletal muscles, with a r..

Identification of Metabolically Distinct Adipocyte Progenitor Cells in Human Adipose Tissues

Arthe Raajendiran, Geraldine Ooi, Jackie Bayliss, Paul E O'Brien, Ralf B Schittenhelm, Ashlee K Clark, Renea A Taylor, Matthew S Rodeheffer, Paul R Burton, Matthew J Watt

2019-04-30

Adipocyte progenitor cells (APCs) provide the reservoir of regenerative cells to produce new adipocytes, although their identity i..

Impact of Lipotoxicity on Tissue "Cross Talk" and Metabolic Regulation

Magdalene K Montgomery, William De Nardo, Matthew J Watt

2019-03-01

Obesity-associated comorbidities include non-alcoholic fatty liver disease, Type 2 diabetes, and cardiovascular disease. These dis..

Perilipin 5 Deletion in Hepatocytes Remodels Lipid Metabolism and Causes Hepatic Insulin Resistance in Mice

Stacey N Keenan, Ruth C Meex, Jennifer CY Lo, Andrew Ryan, Shuai Nie, Magdalene K Montgomery, Matthew J Watt

2019-03-01

Defects in hepatic lipid metabolism cause nonalcoholic fatty liver disease and insulin resistance, and these pathologies are close..

Suppressing fatty acid uptake has therapeutic effects in preclinical models of prostate cancer

Matthew J Watt, Ashlee K Clark, Luke A Selth, Vanessa R Haynes, Natalie Lister, Richard Rebello, Laura H Porter, Birunthi Niranjan, Sarah T Whitby, Jennifer Lo, Cheng Huang, Ralf B Schittenhelm, Kimberley E Anderson, Luc Furic, Poornima R Wijayaratne, Maria Matzaris, Magdalene K Montgomery, Melissa Papargiris, Sam Norden, Maria Febbraio

2019-02-06

Metabolism alterations are hallmarks of cancer, but the involvement of lipid metabolism in disease progression is unclear. We inve..

The Influence of Aerobic Exercise on Hippocampal Integrity and Function: Preliminary Findings of a Multi-Modal Imaging Analysis.

Lauren Den Ouden, Aaron Kandola, Chao Suo, Joshua Hendrikse, Ricardo JS Costa, Matthew J Watt, Valentina Lorenzetti, Yann Chye, Linden Parkes, Kristina Sabaroedin, Murat Yücel

2018-12-26

Aerobic exercise (AE) interventions represent promising therapeutic approaches in disorders that compromise hippocampal integrity,..

Absence of renal hypoxia in the subacute phase of severe renal ischemia-reperfusion injury.

Connie PC Ow, Jennifer P Ngo, Md Mahbub Ullah, Giannie Barsha, Ruth C Meex, Matthew J Watt, Lucinda M Hilliard, Maarten P Koeners, Roger G Evans

2018-11-01

Tissue hypoxia has been proposed as an important event in renal ischemia-reperfusion injury (IRI), particularly during the period ..

Mitochondrial dysfunction-related lipid changes occur in nonalcoholic fatty liver disease progression

Kang-Yu Peng, Matthew J Watt, Sander Rensen, Jan Willem Greve, Kevin Huynh, Kaushala S Jayawardana, Peter J Meikle, Ruth CR Meex

2018-10-01

Nonalcoholic fatty liver disease (NAFLD) comprises fat-accumulating conditions within hepatocytes that can cause severe liver dama..

Insights into the neurochemical signature of the Innervation of Beige Fat

Aneta Stefanidis, Nicole M Wiedmann, Sonika Tyagi, Andrew M Allen, Matthew J Watt, Brian J Oldfield

2018-05-01

OBJECTIVE: The potential for brown adipose tissue (BAT) to be targeted as a therapeutic option to combat obesity has been heighten..

No evidence of white adipocyte browning after endurance exercise training in obese men

T Tsiloulis, AL Carey, J Bayliss, B Canny, RCR Meex, MJ Watt

2018-04-01

BACKGROUND/OBJECTIVES: The phenomenon of adipocyte 'beiging' involves the conversion of non-classic brown adipocytes to brown-like..

Perilipin 5 Deletion Unmasks an Endoplasmic Reticulum Stress-Fibroblast Growth Factor 21 Axis in Skeletal Muscle

Magdalene K Montgomery, Ruzaidi Mokhtar, Jacqueline Bayliss, Helena C Parkington, Victor M Suturin, Clinton R Bruce, Matthew J Watt

2018-04-01

Lipid droplets (LDs) are critical for the regulation of lipid metabolism, and dysregulated lipid metabolism contributes to the pat..

AgRP Neurons Require Carnitine Acetyltransferase to Regulate Metabolic Flexibility and Peripheral Nutrient Partitioning.

Alex Reichenbach, Romana Stark, Mathieu Mequinion, Raphael RG Denis, Jeferson F Goularte, Rachel E Clarke, Sarah H Lockie, Moyra B Lemus, Greg M Kowalski, Clinton R Bruce, Cheng Huang, Ralf B Schittenhelm, Randall L Mynatt, Brian J Oldfield, Matthew J Watt, Serge Luquet, Zane B Andrews

2018-02-13

AgRP neurons control peripheral substrate utilization and nutrient partitioning during conditions of energy deficit and nutrient r..

Triglyceride metabolism in exercising muscle.

Matthew J Watt, Yunsheng Cheng

2017-10-01

Triglycerides are stored within lipid droplets in skeletal muscle and can be hydrolyzed to produce fatty acids for energy producti..

Increased liver AGEs induce hepatic injury mediated through an OST48 pathway

Aowen Zhuang, Felicia Yt Yap, Clinton Bruce, Chris Leung, Manuel R Plan, Mitchell A Sullivan, Chandana Herath, Domenica McCarthy, Karly C Sourris, Phillip Kantharidis, Melinda T Coughlan, Mark A Febbraio, Mark P Hodson, Matthew J Watt, Peter Angus, Benjamin L Schulz, Josephine M Forbes

2017-09-25

The protein oligosaccharyltransferase-48 (OST48) is integral to protein N-glycosylation in the endoplasmic reticulum (ER) but is a..

Hepatokines: linking nonalcoholic fatty liver disease and insulin resistance.

Ruth CR Meex, Matthew J Watt

2017-09-01

Hepatic steatosis is an underlying feature of nonalcoholic fatty liver disease (NAFLD), which is the most common form of liver dis..

Specific targeting of TGF-beta family ligands demonstrates distinct roles in the regulation of muscle mass in health and disease

Justin L Chen, Kelly L Walton, Adam Hagg, Timothy D Colgan, Katharine Johnson, Hongwei Qian, Paul Gregorevic, Craig A Harrison

2017-06-27

The transforming growth factor-β (TGF-β) network of ligands and intracellular signaling proteins is a subject of intense interest ..

Impact of endurance exercise training on adipocyte microRNA expression in overweight men

Thomas Tsiloulis, Joshua Pike, David Powell, Fernando J Rossello, Benedict J Canny, Ruth CR Meex, Matthew J Watt

2017-01-01

Adipocytes are major regulators of metabolism, and endurance exercise training improves adipocyte function; however, the molecular..

Perilipin 5 is dispensable for normal substrate metabolism and in the adaptation of skeletal muscle to exercise training

Ruzaidi AM Mohktar, Magda K Montgomery, Robyn M Murphy, Matthew J Watt

2016-07-01

Cytoplasmic lipid droplets provide a reservoir for triglyceride storage and are a central hub for fatty acid trafficking in cells...

Fetuin B Is a Secreted Hepatocyte Factor Linking Steatosis to Impaired Glucose Metabolism

Ruth C Meex, Andrew J Hoy, Alexander Morris, Russell D Brown, Jennifer CY Lo, Melissa Burke, Robert JA Goode, Bronwyn A Kingwell, Michael J Kraakman, Mark A Febbraio, Jan Willem Greve, Sander S Rensen, Mark P Molloy, Graeme I Lancaster, Clinton R Bruce, Matthew J Watt

2015-12-01

Liver steatosis is associated with the development of insulin resistance and the pathogenesis of type 2 diabetes. We tested the hy..

ATGL-mediated triglyceride turnover and the regulation of mitochondrial capacity in skeletal muscle

Ruth CR Meex, Andrew J Hoy, Rachael M Mason, Sheree D Martin, Sean L McGee, Clinton R Bruce, Matthew J Watt

2015-06-01

Emerging evidence indicates that skeletal muscle lipid droplets are an important control point for intracellular lipid homeostasis..

Unraveling the roles of PLIN5: linking cell biology to physiology

Rachael R Mason, Matthew J Watt

2015-03-01

The discovery of perilipin (PLIN) 1 provided a major conceptual shift in the understanding of adipose tissue lipolysis and generat..