INSTRUCTING MAMMARY CELL IDENTITY: GENOMIC AND EPIGENOMIC FACTORS REGULATING CELL FATE DURING DEVELOPMENT AND TUMORIGENESIS

Canonical PRC2 function is essential for mammary gland development and affects chromatin compaction in mammary organoids

Ewa M Michalak, Michael JG Milevskiy, Rachel M Joyce, Johanna F Dekkers, Paul R Jamieson, Bhupinder Pal, Caleb A Dawson, Yifang Hu, Stuart H Orkin, Warren S Alexander, Geoffrey J Lindeman, Gordon K Smyth, Jane E Visvader

2018-08-01

Distinct transcriptional states are maintained through organization of chromatin, resulting from the sum of numerous repressive an..

The mammary stem cell field wakes up to hibernating cells.

Ewa M Michalak

2017-01-01

Dysregulation of histone methyltransferases in breast cancer - Opportunities for new targeted therapies?

Ewa M Michalak, Jane E Visvader

2016-12-01

Histone methyltransferases (HMTs) catalyze the methylation of lysine and arginine residues on histone tails and non-histone target..