TRANSCRIPTIONAL AND METABOLIC REGULATION OF EFFECTOR AND MEMORY LYMPHOCYTE DIFFERENTIATION
Grant number: 1139607 | Funding period: 2018 - 2023
I am an internationally recognized expert in the field of lymphocyte biology. My work has shed light on antibody production, T cell responses and immune pathology. Specifically, I have identified molecular regulators that link antigen recognition, lymphocyte population expansion, cellular metabolism and effector function. My ongoing work focusses on the development and function of several critically important cell types, including tissue resident lymphocytes and regulatory T cells.
Related publications (8)
Transforming growth factor-b-regulated mTOR activity preserves cellular metabolism to maintain long-term T cell responses in chronic infection
Sarah S Gabriel, Carlson Tsui, David Chisanga, Flora Weber, Manuela Llano-Leon, Patrick M Gubser, Laurent Bartholin, Fernando Souza-Fonseca-Guimaraes, Nicholas D Huntington, Wei Shi, Daniel T Utzschneider, Axel Kallies
Antigen-specific CD8+ T cells in chronic viral infections and tumors functionally deteriorate, a process known as exhaustion. Exha..
Intact TP-53 function is essential for sustaining durable responses to BH3-mimetic drugs in leukemias
Rachel Thijssen, Sarah T Diepstraten, Donia Moujalled, Edward Chew, Christoffer Flensburg, Melissa X Shi, Michael A Dengler, Veronique Litalien, Sarah MacRaild, Maoshan Chen, Natasha S Anstee, Boris Reljic, Sarah S Gabriel, Tirta M Djajawi, Chris D Riffkin, Brandon J Aubrey, Catherine Chang, Lin Tai, Zhen Xu, Thomas Morley
Selective targeting of BCL-2 with the BH3-mimetic venetoclax has been a transformative treatment for patients with various leukemi..
Dynamic changes to tissue-resident immunity after MHC-matched and MHC-mismatched solid organ transplantation
Amy Prosser, Wen Hua Huang, Liu Liu, Sarah Dart, Monalyssa Watson, Bastiaan de Boer, Philip Kendrew, Andrew Lucas, Irma Larma-Cornwall, Silvana Gaudieri, Gary P Jeffrey, Luc Delriviere, Axel Kallies, Michaela Lucas
The heterogeneous pool of tissue-resident lymphocytes in solid organs mediates infection responses and supports tissue integrity a..
Antigen-driven EGR2 expression is required for exhausted CD8( ) T cell stability and maintenance
Mayura Wagle, Stephin J Vervoort, Madison J Kelly, Willem Van der Byl, Timothy J Peters, Ben P Martin, Luciano G Martelotto, Simone Nuessing, Kelly M Ramsbottom, James R Torpy, Deborah Knight, Sinead Reading, Kevin Thia, Lisa A Miosge, Debbie R Howard, Renee Gloury, Sarah S Gabriel, Daniel T Utzschneider, Jane Oliaro, Jonathan D Powell
Chronic stimulation of CD8+ T cells triggers exhaustion, a distinct differentiation state with diminished effector function. Exhau..
Cellular networks controlling T cell persistence in adoptive cell therapy
Jack D Chan, Junyun Lai, Clare Y Slaney, Axel Kallies, Paul A Beavis, Phillip K Darcy
The antitumour activity of endogenous or adoptively transferred tumour-specific T cells is highly dependent on their differentiati..
Early precursor T cells establish and propagate T cell exhaustion in chronic infection
Daniel T Utzschneider, Sarah S Gabriel, David Chisanga, Renee Gloury, Patrick M Gubser, Ajithkumar Vasanthakumar, Wei Shi, Axel Kallies
CD8+ T cells responding to chronic infections or tumors acquire an 'exhausted' state associated with elevated expression of inhibi..
Sex-specific adipose tissue imprinting of regulatory T cells
Ajithkumar Vasanthakumar, David Chisanga, Jonas Blume, Renee Gloury, Kara Britt, Darren C Henstridge, Yifan Zhan, Santiago Valle Torres, Sebastian Liene, Nicholas Collins, Enyuan Cao, Tom Sidwell, Chaoran Li, Raul German Spallanzani, Yang Liao, Paul A Beavis, Thomas Gebhardt, Natalie Trevaskis, Stephen L Nutt, Jeffrey D Zajac
Adipose tissue is an energy store and a dynamic endocrine organ1,2. In particular, visceral adipose tissue (VAT) is critical for t..