PROTECTIVE MECHANISMS OF MAP KINASE PHOSPHATASE 5 IN ADIPOSE TISSUE FIBROSIS, HEPATIC STEATOSIS AND ATHEROSCLEROSIS

Abstract

Obesity and associated complications such as diabetes, non-alcoholic fatty liver disease and atherosclerosis are a serious health burden. Recently, we found that MKP5, a molecule that restricts intracellular signaling, plays a central role in preventing these diseases. This collaborative project will elucidate how precisely MKP5 acts and explore how this molecule can be targeted for the development of novel therapeutic strategies in prevention and treatment of human metabolic diseases.