ADDRESSING THE MAJOR CHALLENGES IN HIV VACCINE AND CURE RESEARCH
Grant number: 1149990 | Funding period: 2019 - 2023
HIV remains one of the defining global health challenge of our times. 37 million people are living with HIV with 2 million new infections each year. Despite advances in management of HIV infection with antiretroviral therapy, there is still no cure, no effective vaccine, and several co-infections reduce life expectancy. This program assembles Australia’s leading HIV researchers to use innovative basic and translational science to tackle priority areas in controlling the HIV epidemic.
Related publications (5)
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DNA-based materials have attracted interest due to the tunable structure and encoded biological functionality of nucleic acids. A ..
Experimental Quantification of Interactions Between Drug Delivery Systems and Cells In Vitro: A Guide for Preclinical Nanomedicine Evaluation
Paula M Cevaal, Michael Roche, Sharon R Lewin, Frank Caruso, Matthew Faria
A major component of designing drug delivery systems concerns how to amplify or attenuate interactions with specific cell types. F..
Anti-PEG Antibodies Boosted in Humans by SARS-CoV-2 Lipid Nanoparticle mRNA Vaccine
Yi Ju, Wen Shi Lee, Emily H Pilkington, Hannah G Kelly, Shiyao Li, Kevin J Selva, Kathleen M Wragg, Kanta Subbarao, Thi HO Nguyen, Louise C Rowntree, Lilith F Allen, Katherine Bond, Deborah A Williamson, Nghia P Truong, Magdalena Plebanski, Katherine Kedzierska, Siddhartha Mahanty, Amy W Chung, Frank Caruso, Adam K Wheatley
Humans commonly have low level antibodies to poly(ethylene) glycol (PEG) due to environmental exposure. Lipid nanoparticle (LNP) m..
A Focus on "Bio" in Bio-Nanoscience: The Impact of Biological Factors on Nanomaterial Interactions
Christina Cortez-Jugo, Ewa Czuba-Wojnilowicz, Abigail Tan, Frank Caruso
Bio-nanoscience research encompasses studies on the interactions of nanomaterials with biological structures or what is commonly r..
Self-assembling influenza nanoparticle vaccines drive extended germinal center activity and memory B cell maturation.
Hannah G Kelly, Hyon-Xhi Tan, Jennifer A Juno, Robyn Esterbauer, Yi Ju, Wenbo Jiang, Verena C Wimmer, Brigette C Duckworth, Joanna R Groom, Frank Caruso, Masaru Kanekiyo, Stephen J Kent, Adam K Wheatley
Protein-based, self-assembling nanoparticles elicit superior immunity compared with soluble protein vaccines, but the immune mecha..