Investigating Follistatin-Based Interventions for Long Term-Protection Against Frailty Associated With Chronic Illness and Aging

Grant number: 1121500 | Funding period: 2018 - 2021

Completed

Abstract

Effective therapies are urgently needed to combat frailty arising from muscle wasting associated with chronic illness and aging. The proposed studies will investigate the prospects of developing novel short-term interventions that can confer long-term benefits for preventing and treating muscle wasting associated with chronic illness and advanced aging.

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Dynamic changes to the skeletal muscle proteome and ubiquitinome induced by the E3 ligase, ASB2β

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Ubiquitination is a posttranslational protein modification that has been shown to have a range of effects, including regulation of..

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TMEPAI/PMEPA1 Is a Positive Regulator of Skeletal Muscle Mass

A Hagg, S Kharoud, G Goodchild, CA Goodman, JL Chen, RE Thomson, H Qian, P Gregorevic, CA Harrison, KL Walton

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Inhibition of myostatin- and activin-mediated SMAD2/3 signaling using ligand traps, such as soluble receptors, ligand-targeting pr..

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Intravascular Follistatin gene delivery improves glycemic control in a mouse model of type 2 diabetes

JR Davey, E Estevez, RE Thomson, M Whitham, KI Watt, A Hagg, H Qian, DC Henstridge, H Ludlow, MP Hedger, SL McGee, MT Coughlan, MA Febbraio, P Gregorevic

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Type 2 diabetes (T2D) manifests from inadequate glucose control due to insulin resistance, hypoinsulinemia, and deteriorating panc..

University of Melbourne Researchers