INVESTIGATING FOLLISTATIN-BASED INTERVENTIONS FOR LONG TERM-PROTECTION AGAINST FRAILTY ASSOCIATED WITH CHRONIC ILLNESS AND AGING
Grant number: 1121500 | Funding period: 2018 - 2021
Effective therapies are urgently needed to combat frailty arising from muscle wasting associated with chronic illness and aging. The proposed studies will investigate the prospects of developing novel short-term interventions that can confer long-term benefits for preventing and treating muscle wasting associated with chronic illness and advanced aging.
Related publications (2)
Dynamic Changes to the Skeletal Muscle Proteome and Ubiquitinome Induced by the E3 Ligase, ASB2β.
Craig A Goodman, Jonathan R Davey, Adam Hagg, Benjamin L Parker, Paul Gregorevic
Ubiquitination is a posttranslational protein modification that has been shown to have a range of effects, including regulation of..
Intravascular Follistatin gene delivery improves glycemic control in a mouse model of type 2 diabetes
Jonathan R Davey, Emma Estevez, Rachel E Thomson, Martin Whitham, Kevin I Watt, Adam Hagg, Hongwei Qian, Darren C Henstridge, Helen Ludlow, Mark P Hedger, Sean L McGee, Melinda T Coughlan, Mark A Febbraio, Paul Gregorevic
Type 2 diabetes (T2D) manifests from inadequate glucose control due to insulin resistance, hypoinsulinemia, and deteriorating panc..