WOLBACHIA FOR BIOCONTROL OF EMERGENT ARBOVIRUSES

Genomic and Phenotypic Comparisons Reveal Distinct Variants of Wolbachia Strain wAlbB

Julien Martinez, Perran A Ross, Xinyue Gu, Thomas H Ant, Shivan M Murdochy, Lily Tong, Ana da Silva Filipe, Ary A Hoffmann, Steven P Sinkins

2022-11-01

The intracellular bacterium Wolbachia inhibits virus replication and is being harnessed around the world to fight mosquito-borne d..

Spatio-Temporal Modelling Informing Wolbachia Replacement Releases in a Low Rainfall Climate

Dan Pagendam, Samia Elfekih, Majed S Nassar, Samuel Nelson, Abdulaziz M Almalik, Essam A Tawfik, Mohamed B Al-Fageeh, Ary A Hoffmann

2022-10-01

Releases of Aedes aegypti carrying Wolbachia bacteria are known to suppress arbovirus transmission and reduce the incidence of vec..

Extensive public health initiatives drive the elimination of Aedes aegypti (Diptera, Culicidae) from a town in regional Queensland: A case study from Gin Gin, Australia

Brendan J Trewin, Brian Montgomery, Tim Hurst, Jason Gilmore, Nancy Endersby-Harshman, Greg J Crisp

2022-04-01

Aedes aegypti is the primary vector of exotic arboviruses (dengue, chikungunya and Zika) in Australia. Once established across muc..

A wMel Wolbachia variant in Aedes aegypti from field-collected Drosophila melanogaster with increased phenotypic stability under heat stress

Xinyue Gu, Perran A Ross, Julio Rodriguez-Andres, Katie L Robinson, Qiong Yang, Meng-Jia Lau, Ary A Hoffmann

2022-03-23

Mosquito-borne diseases remain a major cause of morbidity and mortality. Population replacement strategies involving the wMel stra..

A decade of stability for wMel Wolbachia in natural Aedes aegypti populations

Perran P Ross, Katie M Robinson, Qiong Yang, Ashley A Callahan, Thomas Schmidt, Jason Axford, Marianne A Coquilleau, Kyran Staunton, Michael Townsend, Scott Ritchie, Meng-Jia Lau, Xinyue Gu, Ary Hoffmann

2022-02-23

Mosquitoes carrying Wolbachia endosymbionts are being released in many countries for arbovirus control. The wMel strain of Wolbach..

Genetic stability of Aedes aegypti populations following invasion by wMel Wolbachia

Meng-Jia Lau, Thomas L Schmidt, Qiong Yang, Jessica Chung, Lucien Sankey, Perran A Ross, Ary A Hoffmann

2021-12-14

BACKGROUND: Wolbachia wMel is the most commonly used strain in rear and release strategies for Aedes aegypti mosquitoes that aim t..

Estimating dispersal using close kin dyads: The kindisperse R package

Moshe E Jasper, Ary A Hoffmann, Thomas L Schmidt

2021-10-10

Investigating dispersal in animal populations can be difficult, particularly for taxa that are hard to directly observe such as th..

A wAlbB Wolbachia Transinfection Displays Stable Phenotypic Effects across Divergent Aedes aegypti Mosquito Backgrounds

Perran A Ross, Xinyue Gu, Katie L Robinson, Qiong Yang, Ellen Cottingham, Yifan Zhang, Heng Lin Yeap, Xuefen Xu, Nancy M Endersby-Harshman, Ary A Hoffmann

2021-10-01

Aedes mosquitoes harboring intracellular Wolbachia bacteria are being released in arbovirus and mosquito control programs. With re..

Long-Range But Not Short-Range Attraction of Male Aedes aegypti (Diptera: Culicidae) Mosquitoes to Humans

Brogan A Amos, Ary A Hoffmann, Kyran M Staunton, Meng-Jia Lau, Thomas R Burkot, Perran A Ross

2021-09-24

Female Aedes aegypti (Linnaeus) mosquitoes integrate multiple sensory cues to locate human hosts for blood meals. Although male Ae..

A diagnostic primer pair to distinguish between wMel and wAlbB Wolbachia infections

Meng-Jia Lau, Ary A Hoffmann, Nancy M Endersby-Harshman

2021-09-23

Detection of the Wolbachia endosymbiont in Aedes aegypti mosquitoes through real-time polymerase chain reaction assays is widely u..

Improving mosquito control strategies with population genomics

Thomas L Schmidt, Nancy M Endersby-Harshman, Ary A Hoffmann

2021-09-15

Mosquito control strategies increasingly apply knowledge from population genomics research. This review highlights recent applicat..

Unbiased population heterozygosity estimates from genome-wide sequence data

Thomas L Schmidt, Moshe-Elijah Jasper, Andrew R Weeks, Ary A Hoffmann

2021-07-01

Heterozygosity is a metric of genetic variability frequently used to inform the management of threatened taxa. Estimating observed..

Infertility and fecundity loss of Wolbachia-infected Aedes aegypti hatched from quiescent eggs is expected to alter invasion dynamics

Meng-Jia Lau, Perran A Ross, Ary A Hoffmann

2021-02-01

The endosymbiotic bacterium Wolbachia shows viral blocking in its mosquito host, leading to its use in arboviral disease control. ..

Wolbachia Genome Stability and mtDNA Variants in Aedes aegypti Field Populations Eight Years after Release

Bixing Huang, Qiong Yang, Ary A Hoffmann, Scott A Ritchie, Andrew F van den Hurk, David Warrilow

2020-10-23

A dengue suppression strategy based on release of Aedes aegypti mosquitoes infected with the bacterium Wolbachia pipientis is bein..

Modulation of acyl-carnitines, the broad mechanism behind Wolbachia-mediated inhibition of medically important flaviviruses in Aedes aegypti

Gayathri Manokaran, Heather A Flores, Conor T Dickson, Vinod K Narayana, Komal Kanojia, Saravanan Dayalan, Dedreia Tull, Malcolm J McConville, Jason M Mackenzie, Cameron P Simmons

2020-09-29

Wolbachia-infected mosquitoes are refractory to flavivirus infections, but the role of lipids in Wolbachia-mediated virus blocking..

Impacts of Low Temperatures on Wolbachia (Rickettsiales: Rickettsiaceae)-Infected Aedes aegypti (Diptera: Culicidae)

Meng-Jia Lau, Perran A Ross, Nancy M Endersby-Harshman, Ary A Hoffmann

2020-09-01

In recent decades, the occurrence and distribution of arboviral diseases transmitted by Aedes aegypti mosquitoes has increased. In..

Frequency of kdr mutations in the voltage-sensitive sodium channel (V-SSC) gene in Aedes aegypti from Yogyakarta and implications for Wolbachia-infected mosquito trials

Juli Rochmijati Wuliandari, Ary A Hoffmann, Warsito Tantowijoyo, Nancy M Endersby-Harshman

2020-08-24

Background In the inner city of Yogyakarta, Indonesia, insecticide resistance is expected in the main dengue vector, Aedes aegypti..

Characterization of Sodium Channel Mutations in the Dengue Vector MosquitoesAedesaegyptiandAedesalbopictuswithin the Context of OngoingWolbachiaReleases in Kuala Lumpur, Malaysia

Noor Afizah Ahmad, Nancy M Endersby-Harshman, Nur Ruqqayah Mohd Mazni, Nur Zatil Aqmar Mohd Zabari, Siti Nor Syazwani Amran, Muhammad Kamarul Ridhuan Ghazali, Mohd Arif Abdul Karim, Yoon Ling Cheong, Steven P Sinkins, Nazni Wasi Ahmad, Ary A Hoffmann

2020-08-01

Specific sodium channel gene mutations confer target site resistance to pyrethroid insecticides in mosquitoes and other insects. I..

Heterogeneous genetic invasions of three insecticide resistance mutations in Indo-Pacific populations of Aedes aegypti (L.)

Nancy M Endersby-Harshman, Thomas L Schmidt, Jessica Chung, Anthony van Rooyen, Andrew R Weeks, Ary A Hoffmann

2020-04-21

Nations throughout the Indo-Pacific region use pyrethroid insecticides to control Aedes aegypti, the mosquito vector of dengue, of..

Persistent deleterious effects of a deleterious Wolbachia infection

Perran A Ross, Jason K Axford, Ashley G Callahan, Kelly M Richardson, Ary A Hoffmann

2020-04-03

Wolbachia are being used to reduce dengue transmission by Aedes aegypti mosquitoes around the world. To date releases have mostly ..

An elusive endosymbiont: Does Wolbachia occur naturally in Aedes aegypti?

Perran A Ross, Ashley G Callahan, Qiong Yang, Moshe Jasper, Mohd AK Arif, Ahmad Noor Afizah, Wasi A Nazni, Ary A Hoffmann

2020-02-16

Wolbachia are maternally inherited endosymbiotic bacteria found within many insect species. Aedes mosquitoes experimentally infect..

Heatwaves cause fluctuations in wMel Wolbachia densities and frequencies in Aedes aegypti

Perran A Ross, Jason K Axford, Qiong Yang, Kyran M Staunton, Scott A Ritchie, Kelly M Richardson, Ary A Hoffmann

2020-01-01

Aedes aegypti mosquitoes infected with the wMel strain of Wolbachia are being released into natural mosquito populations in the tr..

Measuring the Host-Seeking Ability of Aedes aegypti Destined for Field Release

Meng-Jia Lau, Nancy M Endersby-Harshman, Jason K Axford, Scott A Ritchie, Ary A Hoffmann, Perran A Ross

2020-01-01

Host seeking is an essential process in mosquito reproduction. Field releases of modified mosquitoes for population replacement re..

Establishment of Wolbachia Strain wAlbB in Malaysian Populations of Aedes aegypti for Dengue Control

Wasi A Nazni, Ary A Hoffmann, Ahmad NoorAfizah, Yoon Ling Cheong, Maria V Mancini, Nicholas Golding, Ghazali MR Kamarul, Mohd AK Arif, Hasim Thohir, Halim NurSyamimi, M Zabari ZatilAqmar, Mazni NurRuqqayah, Amran NorSyazwani, Azmi Faiz, Francis-Rudin MN Irfan, Subramaniam Rubaaini, Nasir Nuradila, Nasir MN Nizam, Saidin M Irwan, Nancy M Endersby-Harshman

2019-12-16

Dengue has enormous health impacts globally. A novel approach to decrease dengue incidence involves the introduction of Wolbachia ..

A LAMP assay for the rapid and robust assessment of Wolbachia infection in Aedes aegypti under field and laboratory conditions

Moshe E Jasper, Qiong Yang, Perran A Ross, Nancy Endersby-Harshman, Nicholas Bell, Ary A Hoffmann

2019-11-20

With Wolbachia-based arbovirus control programs being scaled and operationalised around the world, cost effective and reliable det..

Does membrane feeding compromise the quality of Aedes aegypti mosquitoes?

Perran A Ross, Meng-Jia Lau, Ary A Hoffmann

2019-11-06

Modified Aedes aegypti mosquitoes are being mass-reared for release in disease control programs around the world. Releases involvi..

A genomic approach to inferring kinship reveals limited intergenerational dispersal in the yellow fever mosquito

Moshe Jasper, Thomas L Schmidt, Nazni W Ahmad, Steven P Sinkins, Ary A Hoffmann

2019-09-01

Understanding past dispersal and breeding events can provide insight into ecology and evolution and can help inform strategies for..

Loss of cytoplasmic incompatibility in Wolbachia-infected Aedes aegypti under field conditions

Perran A Ross, Scott A Ritchie, Jason K Axford, Ary A Hoffmann

2019-04-01

Wolbachia bacteria are now being introduced into Aedes aegypti mosquito populations for dengue control. When Wolbachia infections ..

Cross-Generational Effects of Heat Stress on Fitness and Wolbachia Density in Aedes aegypti Mosquitoes

Isabelle Jia-Hui Foo, Ary A Hoffmann, Perran A Ross

2019-03-01

Aedes aegypti mosquitoes infected with Wolbachia symbionts are now being released into the field to control the spread of pathogen..

Effects of Alternative Blood Sources on Wolbachia Infected Aedes aegypti Females within and across Generations

Veronique Paris, Ellen Cottingham, Perran A Ross, Jason K Axford, Ary A Hoffmann

2018-12-01

Wolbachia bacteria have been identified as a tool for reducing the transmission of arboviruses transmitted by Aedes aegypti. Resea..