WOLBACHIA FOR BIOCONTROL OF EMERGENT ARBOVIRUSES
Grant number: 1132412 | Funding period: 2018 - 2022
Dengue, Zika and Chikungunya are viral diseases transmitted to humans by mosquitoes. Our research uses a naturally-occurring bacteria, Wolbachia, to stop mosquitoes transmitting these viruses to humans. Our proposal addresses critical knowledge gaps in the biology of mosquitoes and Wolbachia to enable large-scale field-deployment optimisation in affected countries. The outcome of our research will immediately translate to disease control efforts in northern Australia, Asia and Latin America.
Related publications (30)
Genomic and Phenotypic Comparisons Reveal Distinct Variants of Wolbachia Strain wAlbB
Julien Martinez, Perran A Ross, Xinyue Gu, Thomas H Ant, Shivan M Murdochy, Lily Tong, Ana da Silva Filipe, Ary A Hoffmann, Steven P Sinkins
The intracellular bacterium Wolbachia inhibits virus replication and is being harnessed around the world to fight mosquito-borne d..
Spatio-Temporal Modelling Informing Wolbachia Replacement Releases in a Low Rainfall Climate
Dan Pagendam, Samia Elfekih, Majed S Nassar, Samuel Nelson, Abdulaziz M Almalik, Essam A Tawfik, Mohamed B Al-Fageeh, Ary A Hoffmann
Releases of Aedes aegypti carrying Wolbachia bacteria are known to suppress arbovirus transmission and reduce the incidence of vec..
Extensive public health initiatives drive the elimination of Aedes aegypti (Diptera, Culicidae) from a town in regional Queensland: A case study from Gin Gin, Australia
Brendan J Trewin, Brian Montgomery, Tim Hurst, Jason Gilmore, Nancy Endersby-Harshman, Greg J Crisp
Aedes aegypti is the primary vector of exotic arboviruses (dengue, chikungunya and Zika) in Australia. Once established across muc..
A wMel Wolbachia variant in Aedes aegypti from field-collected Drosophila melanogaster with increased phenotypic stability under heat stress
Xinyue Gu, Perran A Ross, Julio Rodriguez-Andres, Katie L Robinson, Qiong Yang, Meng-Jia Lau, Ary A Hoffmann
Mosquito-borne diseases remain a major cause of morbidity and mortality. Population replacement strategies involving the wMel stra..
A decade of stability for wMel Wolbachia in natural Aedes aegypti populations
Perran P Ross, Katie M Robinson, Qiong Yang, Ashley A Callahan, Thomas Schmidt, Jason Axford, Marianne A Coquilleau, Kyran Staunton, Michael Townsend, Scott Ritchie, Meng-Jia Lau, Xinyue Gu, Ary Hoffmann
Mosquitoes carrying Wolbachia endosymbionts are being released in many countries for arbovirus control. The wMel strain of Wolbach..
Genetic stability of Aedes aegypti populations following invasion by wMel Wolbachia
Meng-Jia Lau, Thomas L Schmidt, Qiong Yang, Jessica Chung, Lucien Sankey, Perran A Ross, Ary A Hoffmann
BACKGROUND: Wolbachia wMel is the most commonly used strain in rear and release strategies for Aedes aegypti mosquitoes that aim t..
A wAlbB Wolbachia Transinfection Displays Stable Phenotypic Effects across Divergent Aedes aegypti Mosquito Backgrounds
Perran A Ross, Xinyue Gu, Katie L Robinson, Qiong Yang, Ellen Cottingham, Yifan Zhang, Heng Lin Yeap, Xuefen Xu, Nancy M Endersby-Harshman, Ary A Hoffmann
Aedes mosquitoes harboring intracellular Wolbachia bacteria are being released in arbovirus and mosquito control programs. With re..
Long-Range But Not Short-Range Attraction of Male Aedes aegypti (Diptera: Culicidae) Mosquitoes to Humans
Brogan A Amos, Ary A Hoffmann, Kyran M Staunton, Meng-Jia Lau, Thomas R Burkot, Perran A Ross
Female Aedes aegypti (Linnaeus) mosquitoes integrate multiple sensory cues to locate human hosts for blood meals. Although male Ae..
Infertility and fecundity loss of Wolbachia-infected Aedes aegypti hatched from quiescent eggs is expected to alter invasion dynamics
Meng-Jia Lau, Perran A Ross, Ary A Hoffmann
The endosymbiotic bacterium Wolbachia shows viral blocking in its mosquito host, leading to its use in arboviral disease control. ..
Wolbachia Genome Stability and mtDNA Variants in Aedes aegypti Field Populations Eight Years after Release
Bixing Huang, Qiong Yang, Ary A Hoffmann, Scott A Ritchie, Andrew F van den Hurk, David Warrilow
A dengue suppression strategy based on release of Aedes aegypti mosquitoes infected with the bacterium Wolbachia pipientis is bein..
Modulation of acyl-carnitines, the broad mechanism behind Wolbachia-mediated inhibition of medically important flaviviruses in Aedes aegypti
Gayathri Manokaran, Heather A Flores, Conor T Dickson, Vinod K Narayana, Komal Kanojia, Saravanan Dayalan, Dedreia Tull, Malcolm J McConville, Jason M Mackenzie, Cameron P Simmons
Wolbachia-infected mosquitoes are refractory to flavivirus infections, but the role of lipids in Wolbachia-mediated virus blocking..
Impacts of Low Temperatures on Wolbachia (Rickettsiales: Rickettsiaceae)-Infected Aedes aegypti (Diptera: Culicidae)
Meng-Jia Lau, Perran A Ross, Nancy M Endersby-Harshman, Ary A Hoffmann
In recent decades, the occurrence and distribution of arboviral diseases transmitted by Aedes aegypti mosquitoes has increased. In..
Frequency of kdr mutations in the voltage-sensitive sodium channel (V-SSC) gene in Aedes aegypti from Yogyakarta and implications for Wolbachia-infected mosquito trials
Juli Rochmijati Wuliandari, Ary A Hoffmann, Warsito Tantowijoyo, Nancy M Endersby-Harshman
Background In the inner city of Yogyakarta, Indonesia, insecticide resistance is expected in the main dengue vector, Aedes aegypti..
Characterization of Sodium Channel Mutations in the Dengue Vector MosquitoesAedesaegyptiandAedesalbopictuswithin the Context of OngoingWolbachiaReleases in Kuala Lumpur, Malaysia
Noor Afizah Ahmad, Nancy M Endersby-Harshman, Nur Ruqqayah Mohd Mazni, Nur Zatil Aqmar Mohd Zabari, Siti Nor Syazwani Amran, Muhammad Kamarul Ridhuan Ghazali, Mohd Arif Abdul Karim, Yoon Ling Cheong, Steven P Sinkins, Nazni Wasi Ahmad, Ary A Hoffmann
Specific sodium channel gene mutations confer target site resistance to pyrethroid insecticides in mosquitoes and other insects. I..
Heterogeneous genetic invasions of three insecticide resistance mutations in Indo-Pacific populations of Aedes aegypti (L.)
Nancy M Endersby-Harshman, Thomas L Schmidt, Jessica Chung, Anthony van Rooyen, Andrew R Weeks, Ary A Hoffmann
Nations throughout the Indo-Pacific region use pyrethroid insecticides to control Aedes aegypti, the mosquito vector of dengue, of..
An elusive endosymbiont: Does Wolbachia occur naturally in Aedes aegypti?
Perran A Ross, Ashley G Callahan, Qiong Yang, Moshe Jasper, Mohd AK Arif, Ahmad Noor Afizah, Wasi A Nazni, Ary A Hoffmann
Wolbachia are maternally inherited endosymbiotic bacteria found within many insect species. Aedes mosquitoes experimentally infect..
Heatwaves cause fluctuations in wMel Wolbachia densities and frequencies in Aedes aegypti
Perran A Ross, Jason K Axford, Qiong Yang, Kyran M Staunton, Scott A Ritchie, Kelly M Richardson, Ary A Hoffmann
Aedes aegypti mosquitoes infected with the wMel strain of Wolbachia are being released into natural mosquito populations in the tr..
Measuring the Host-Seeking Ability of Aedes aegypti Destined for Field Release
Meng-Jia Lau, Nancy M Endersby-Harshman, Jason K Axford, Scott A Ritchie, Ary A Hoffmann, Perran A Ross
Host seeking is an essential process in mosquito reproduction. Field releases of modified mosquitoes for population replacement re..
Establishment of Wolbachia Strain wAlbB in Malaysian Populations of Aedes aegypti for Dengue Control
Wasi A Nazni, Ary A Hoffmann, Ahmad NoorAfizah, Yoon Ling Cheong, Maria V Mancini, Nicholas Golding, Ghazali MR Kamarul, Mohd AK Arif, Hasim Thohir, Halim NurSyamimi, M Zabari ZatilAqmar, Mazni NurRuqqayah, Amran NorSyazwani, Azmi Faiz, Francis-Rudin MN Irfan, Subramaniam Rubaaini, Nasir Nuradila, Nasir MN Nizam, Saidin M Irwan, Nancy M Endersby-Harshman
Dengue has enormous health impacts globally. A novel approach to decrease dengue incidence involves the introduction of Wolbachia ..
A LAMP assay for the rapid and robust assessment of Wolbachia infection in Aedes aegypti under field and laboratory conditions
Moshe E Jasper, Qiong Yang, Perran A Ross, Nancy Endersby-Harshman, Nicholas Bell, Ary A Hoffmann
With Wolbachia-based arbovirus control programs being scaled and operationalised around the world, cost effective and reliable det..
A genomic approach to inferring kinship reveals limited intergenerational dispersal in the yellow fever mosquito
Moshe Jasper, Thomas L Schmidt, Nazni W Ahmad, Steven P Sinkins, Ary A Hoffmann
Understanding past dispersal and breeding events can provide insight into ecology and evolution and can help inform strategies for..
Loss of cytoplasmic incompatibility in Wolbachia-infected Aedes aegypti under field conditions
Perran A Ross, Scott A Ritchie, Jason K Axford, Ary A Hoffmann
Wolbachia bacteria are now being introduced into Aedes aegypti mosquito populations for dengue control. When Wolbachia infections ..
Effects of Alternative Blood Sources on Wolbachia Infected Aedes aegypti Females within and across Generations
Veronique Paris, Ellen Cottingham, Perran A Ross, Jason K Axford, Ary A Hoffmann
Wolbachia bacteria have been identified as a tool for reducing the transmission of arboviruses transmitted by Aedes aegypti. Resea..