ENGINEERING THE TRAFFICKING OF NANOPARTICLES WITHIN CELLS

Abstract

This project aims to engineer responsive nanoparticles capable of trafficking efficiently within cells. The site of release of therapeutic cargo has importance for improving the efficacy of many treatments, for example vaccine delivery. Therefore fundamental understanding of how nanoparticle structure can be engineered to control cellular behaviour is necessary. The project will engineer new polymeric nanomaterials and investigate the impact of their structure on biological properties. The benefits of this project will include new fundamental insights into improving nanoparticle design for vaccine delivery, as well as the expansion of Australia’s knowledge base in the area of biodegradable p..

Related publications (1)

Rationale Design of pH-Responsive Core-Shell Nanoparticles: Polyoxometalate-Mediated Structural Reorganization

Y Gao, J Xu, C Zhang, H Venugopal, SS Kermaniyan, G Such, C Ritchie

2020-11-25

Herein, we report the rational design of pH-responsive core-shell nanoparticles that incorporate a polyoxometalate (POM) cargo. Co..