NEUROPSYCHIATRIC CONNECTOMICS

The Role of School Environment in Brain Structure, Connectivity, and Mental Health in Children: A Multimodal Investigation.

Divyangana Rakesh, Andrew Zalesky, Sarah Whittle

2023-01-01

BACKGROUND: Much work has been dedicated to understanding the effects of adverse home environments on brain development. While the..

Mechanisms of imbalanced frontostriatal functional connectivity in obsessive-compulsive disorder

Sebastien Naze, Luke J Hearne, James A Roberts, Paula Sanz-Leon, Bjorn Burgher, Caitlin Hall, Saurabh Sonkusare, Zoie Nott, Leo Marcus, Emma Savage, Conor Robinson, Ye Ella Tian, Andrew Zalesky, Michael Breakspear, Luca Cocchi

2022-11-16

The diagnosis of obsessive-compulsive disorder (OCD) has been linked with changes in frontostriatal resting-state connectivity. Ho..

Personalized brain stimulation of memory networks.

Robin FH Cash, Joshua Hendrikse, Kavisha B Fernando, Sarah Thompson, Chao Suo, Alex Fornito, Murat Yücel, Nigel C Rogasch, Andrew Zalesky, James P Coxon

2022-09-01

BACKGROUND: The finding that transcranial magnetic stimulation (TMS) can enhance memory performance via stimulation of parietal si..

Assessment of Parent Income and Education, Neighborhood Disadvantage, and Child Brain Structure.

Divyangana Rakesh, Andrew Zalesky, Sarah Whittle

2022-08-01

IMPORTANCE: Although different aspects of socioeconomic status (SES) may represent distinct risk factors for poor mental health in..

Cell type-specific manifestations of cortical thickness heterogeneity in schizophrenia

Maria A Di Biase, Michael P Geaghan, William R Reay, Jakob Seidlitz, Cynthia Shannon Weickert, Alice Pebay, Melissa J Green, Yann Quide, Joshua R Atkins, Michael J Coleman, Sylvain Bouix, Evdokiya E Knyazhanskaya, Amanda E Lyall, Ofer Pasternak, Marek Kubicki, Yogesh Rathi, Andrew Visco, Megan Gaunnac, Jinglei Lv, Raquelle Mesholam-Gately

2022-02-10

Brain morphology differs markedly between individuals with schizophrenia, but the cellular and genetic basis of this heterogeneity..

Using Brain Imaging to Improve Spatial Targeting of Transcranial Magnetic Stimulation for Depression

FH Robin Cash, Anne Weigand, Andrew Zalesky, H Shan Siddiqi, Jonathan Downar, B Paul Fitzgerald, D Michael Fox

2021-10-18

Transcranial magnetic stimulation (TMS) is an effective treatment for depression but is limited in that the optimal therapeutic ta..

Associations Between Neighborhood Disadvantage, Resting-State Functional Connectivity, and Behavior in the Adolescent Brain Cognitive Development Study: The Moderating Role of Positive Family and School Environments

Divyangana Rakesh, Caio Seguin, Andrew Zalesky, Vanessa Cropley, Sarah Whittle

2021-09-07

BACKGROUND: Neighborhood disadvantage has consistently been associated with mental health and cognitive function, in addition to a..

Similar but distinct - Effects of different socioeconomic indicators on resting state functional connectivity: Findings from the Adolescent Brain Cognitive Development (ABCD) Study

Divyangana Rakesh, Andrew Zalesky, Sarah Whittle

2021-08-19

Early socioeconomic status (SES) has consistently been associated with child health and cognitive outcomes, in addition to alterat..

Neighborhood disadvantage and longitudinal brain-predicted-age trajectory during adolescence

Divyangana Rakesh, Vanessa Cropley, Andrew Zalesky, Nandita Vijayakumar, Nicholas B Allen, Sarah Whittle

2021-08-17

Neighborhood disadvantage has consistently been linked to alterations in brain structure; however, positive environmental (e.g., p..

Brain-Predicted Age Associates With Psychopathology Dimensions in Youths

Vanessa L Cropley, Ye Tian, Kavisha Fernando, L Sina Mansour, Christos Pantelis, Luca Cocchi, Andrew Zalesky

2021-04-05

BACKGROUND: This study aimed to investigate whether dimensional constructs of psychopathology relate to variation in patterns of b..

Cranioplastic Surgery and Acclimation Training for Awake Mouse fMRI

Tomokazu Tsurugizawa, Kota Tamada, Clement Debacker, Andrew Zalesky, Toru Takumi

2021-04-05

MRI is a promising tool for translational research to link brain function and structure in animal models of disease to patients wi..

Network Analysis of Symptom Comorbidity in Schizophrenia: Relationship to Illness Course and Brain White Matter Microstructure

Hua Ye, Andrew Zalesky, Jinglei Lv, Samantha M Loi, Suheyla Cetin-Karayumak, Yogesh Rathi, Ye Tian, Christos Pantelis, Maria A Di Biase

2021-03-08

INTRODUCTION: Recent network-based analyses suggest that schizophrenia symptoms are intricately connected and interdependent, such..

Unraveling the Consequences of Childhood Maltreatment: Deviations From Typical Functional Neurodevelopment Mediate the Relationship Between Maltreatment History and Depressive Symptoms

Divyangana Rakesh, Clare Kelly, Nandita Vijayakumar, Andrew Zalesky, Nicholas B Allen, Sarah Whittle

2021-03-06

BACKGROUND: Childhood maltreatment is associated with lifelong psychiatric sequelae. However, our understanding of neurobiological..

Large-Scale Evidence for an Association Between Peripheral Inflammation and White Matter Free Water in Schizophrenia and Healthy Individuals

Maria A Di Biase, Andrew Zalesky, Suheyla Cetin-Karayumak, Yogesh Rathi, Jinglei Lv, Danny Boerrigter, Hayley North, Paul Tooney, Christos Pantelis, Ofer Pasternak, Cynthia Shannon Weickert, Vanessa L Cropley

2021-03-01

INTRODUCTION: Clarifying the role of neuroinflammation in schizophrenia is subject to its detection in the living brain. Free-wate..

Personalized connectivity-guided DLPFC-TMS for depression: Advancing computational feasibility, precision and reproducibility

Robin FH Cash, Luca Cocchi, Jinglei Lv, Yumeng Wu, Paul B Fitzgerald, Andrew Zalesky

2021-02-05

Repetitive transcranial magnetic stimulation (rTMS) of the dorsolateral prefrontal cortex (DLPFC) is an established treatment for ..

Altered resting functional connectivity patterns associated with problematic substance use and substance use disorders during adolescence

Divyangana Rakesh, Jinglei Lv, Andrew Zalesky, Nicholas B Allen, Dan Lubman, Murat Yucel, Sarah Whittle

2021-01-15

BACKGROUND: Adolescence is typified by increasing rates of substance use and the development of substance use disorders (SUD). Abe..

High-resolution connectomic fingerprints: Mapping neural identity and behavior

Sina L Mansour, Ye Tian, BT Thomas Yeo, Vanessa Cropley, Andrew Zalesky

2021-01-14

Connectomes are typically mapped at low resolution based on a specific brain parcellation atlas. Here, we investigate high-resolut..

Functional Magnetic Resonance Imaging-Guided Personalization of Transcranial Magnetic Stimulation Treatment for Depression

Robin FH Cash, Luca Cocchi, Jinglei Lv, Paul B Fitzgerald, Andrew Zalesky

2020-11-25

This study assesses whether treatment response for depression could be improved via a single one-site-fits-all dorsolateral prefro..

Network communication models improve the behavioral and functional predictive utility of the human structural connectome

Caio Seguin, Ye Tian, Andrew Zalesky

2020-11-01

The connectome provides the structural substrate facilitating communication between brain regions. We aimed to establish whether a..

Topographic organization of the human subcortex unveiled with functional connectivity gradients

Ye Tian, Daniel S Margulies, Michael Breakspear, Andrew Zalesky

2020-09-28

Brain atlases are fundamental to understanding the topographic organization of the human brain, yet many contemporary human atlase..

Individual deviations from normative models of brain structure in a large cross-sectional schizophrenia cohort

Jinglei Lv, Maria Di Biase, Robin FH Cash, Luca Cocchi, Vanessa L Cropley, Paul Klauser, Ye Tian, Johanna Bayer, Lianne Schmaal, Suheyla Cetin-Karayumak, Yogesh Rathi, Ofer Pasternak, Chad Bousman, Christos Pantelis, Fernando Calamante, Andrew Zalesky

2020-09-22

The heterogeneity of schizophrenia has defied efforts to derive reproducible and definitive anatomical maps of structural brain ch..

Predicting individual improvement in schizophrenia symptom severity at 1-year follow-up: Comparison of connectomic, structural, and clinical predictors

Akhil Kottaram, Leigh A Johnston, Ye Tian, Eleni P Ganella, Liliana Laskaris, Luca Cocchi, Patrick McGorry, Christos Pantelis, Ramamohanarao Kotagiri, Vanessa Cropley, Andrew Zalesky

2020-08-15

In a machine learning setting, this study aims to compare the prognostic utility of connectomic, brain structural, and clinical/de..

Reducing the influence of intramodular connectivity in participation coefficient

Mangor Pedersen, Amir Omidvarnia, James M Shine, Graeme D Jackson, Andrew Zalesky

2020-04-01

Both natural and engineered networks are often modular. Whether a network node interacts with only nodes from its own module or no..

Awake functional MRI detects neural circuit dysfunction in a mouse model of autism

Tomokazu Tsurugizawa, Kota Tamada, Nobukazu Ono, Sachise Karakawa, Yuko Kodama, Clement Debacker, Junichi Hata, Hideyuki Okano, Akihiko Kitamura, Andrew Zalesky, Toru Takumi

2020-02-01

MRI has potential as a translational approach from rodents to humans. However, given that mouse functional MRI (fMRI) uses anesthe..

Co-existence of Network Architectures Supporting the Human Gut Microbiome

Caitlin Hall, Anton Lord, Richard Betzel, Martha Zakrzewski, Lisa A Simms, Andrew Zalesky, Graham Radford-Smith, Luca Cocchi

2019-12-20

Microbial organisms of the human gut microbiome do not exist in isolation but form complex and diverse interactions to maintain he..

Inferring neural signalling directionality from undirected structural connectomes

Caio Seguin, Adeel Razi, Andrew Zalesky

2019-09-19

Neural information flow is inherently directional. To date, investigation of directional communication in the human structural con..

REPLY TO YANG ET AL.: Multilayer network switching and behavior

Mangor Pedersen, Andrew Zalesky, Amir Omidvarnia, Graeme D Jackson

2019-08-20

Free-Water Imaging in White and Gray Matter in Parkinson's Disease

Christina Andica, Koji Kamagata, Taku Hatano, Asami Saito, Wataru Uchida, Takashi Ogawa, Haruka Takeshige-Amano, Andrew Zalesky, Akihiko Wada, Michimasa Suzuki, Akifumi Hagiwara, Ryusuke Irie, Masaaki Hori, Kanako K Kumamaru, Genko Oyama, Yashushi Shimo, Atsushi Umemura, Christos Pantelis, Nobutaka Hattori, Shigeki Aoki

2019-08-01

This study aimed to discriminate between neuroinflammation and neuronal degeneration in the white matter (WM) and gray matter (GM)..

A multivariate neuroimaging biomarker of individual outcome to transcranial magnetic stimulation in depression

Robin FH Cash, Luca Cocchi, Rodney Anderson, Anton Rogachov, Aaron Kucyi, Alexander J Barnett, Andrew Zalesky, Paul B Fitzgerald

2019-07-22

The neurobiology of major depressive disorder (MDD) remains incompletely understood, and many individuals fail to respond to stand..

Subgenual Functional Connectivity Predicts Antidepressant Treatment Response to Transcranial Magnetic Stimulation: Independent Validation and Evaluation of Personalization

Robin FH Cash, Andrew Zalesky, Richard H Thomson, Ye Tian, Luca Cocchi, Paul B Fitzgerald

2019-07-15

Evidence for Network-Based Cortical Thickness Reductions in Schizophrenia

Cassandra MJ Wannan, Vanessa L Cropley, M Mallar Chakravarty, Chad Bousman, Eleni P Ganella, Jason M Bruggemann, Thomas W Weickert, Cynthia Shannon Weickert, Ian Everall, Patrick McGorry, Dennis Velakoulis, Stephen J Wood, Cali F Bartholomeusz, Christos Pantelis, Andrew Zalesky

2019-07-01

OBJECTIVE: Cortical thickness reductions in schizophrenia are irregularly distributed across multiple loci. The authors hypothesiz..

Large-scale brain modes reorganize between infant sleep states and carry prognostic information for preterms

Anton Tokariev, James A Roberts, Andrew Zalesky, Xuelong Zhao, Sampsa Vanhatalo, Michael Breakspear, Luca Cocchi

2019-06-13

Sleep architecture carries vital information about brain health across the lifespan. In particular, the ability to express distinc..

Brain network dynamics in schizophrenia: Reduced dynamism of the default mode network

Akhil Kottaram, Leigh A Johnston, Luca Cocchi, Eleni P Ganella, Ian Everall, Christos Pantelis, Ramamohanarao Kotagiri, Andrew Zalesky

2019-05-01

Complex human behavior emerges from dynamic patterns of neural activity that transiently synchronize between distributed brain net..

Insula Functional Connectivity in Schizophrenia: Subregions, Gradients, and Symptoms

Ye Tian, Andrew Zalesky, Chad Bousman, Ian Everall, Christos Pantelis

2019-04-01

BACKGROUND: The insular cortex is connected to a diverse network of cortical and subcortical areas. This study aimed to investigat..

The impact of fasting on resting state brain networks in mice

Tomokazu Tsurugizawa, Boucif Djemai, Andrew Zalesky

2019-02-27

Fasting is known to influence learning and memory in mice and alter the neural networks that subserve these cognitive functions. W..

Mapping connectomes with diffusion MRI: deterministic or probabilistic tractography?

Tabinda Sarwar, Kotagiri Ramamohanarao, Andrew Zalesky

2019-02-01

PURPOSE: Human connectomics necessitates high-throughput, whole-brain reconstruction of multiple white matter fiber bundles. Scali..

Synchronization lag in post stroke: relation to motor function and structural connectivity

Xin Wang, Caio Seguin, Andrew Zalesky, Wan-wa Wong, Winnie Chiu-wing Chu, Raymond Kai-yu Tong

2019-01-01

Stroke is characterized by delays in the resting-state hemodynamic response, resulting in synchronization lag in neural activity b..

Multilayer network switching rate predicts brain performance

Mangor Pedersen, Andrew Zalesky, Amir Omidvarnia, Graeme D Jackson

2018-12-26

Large-scale brain dynamics are characterized by repeating spatiotemporal connectivity patterns that reflect a range of putative di..

Characterizing the functional connectivity diversity of the insula cortex: Subregions, diversity curves and behavior

Ye Tian, Andrew Zalesky

2018-12-01

The connectivity of the insula cortex is diverse. We present new models to characterize the resting-state connectional diversity o..

On the relationship between instantaneous phase synchrony and correlation-based sliding windows for time-resolved fMRI connectivity analysis

Mangor Pedersen, Amir Omidvarnia, Andrew Zalesky, Graeme D Jackson

2018-11-01

Correlation-based sliding window analysis (CSWA) is the most commonly used method to estimate time-resolved functional MRI (fMRI) ..

Computational Approaches to Understanding Mental Dysfunction: Progress, Challenges, and New Frontiers

Alex Fornito, Andrew Zalesky

2018-09-01

Spatio-temporal dynamics of resting-state brain networks improve single-subject prediction of schizophrenia diagnosis

Akhil Kottaram, Leigh Johnston, Eleni Ganella, Christos Pantelis, Ramamohanarao Kotagiri, Andrew Zalesky

2018-09-01

Correlation in functional MRI activity between spatially separated brain regions can fluctuate dynamically when an individual is a..

Navigation of brain networks

Caio Seguin, Martijn P van den Heuvel, Andrew Zalesky

2018-06-12

Understanding the mechanisms of neural communication in large-scale brain networks remains a major goal in neuroscience. We invest..