USING LESSONS FROM TOXIC SHOCK SYNDROME TO ENHANCE BREAST CANCER IMMUNOTHERAPY

A Histone Deacetylase Inhibitor, Panobinostat, Enhances Chimeric Antigen Receptor T-cell Antitumor Effect Against Pancreatic Cancer

Aesha Ali, Minyu Wang, Bianca von Scheidt, Pilar M Dominguez, Aaron J Harrison, Daniela GM Tantalo, Jian Kang, Amanda J Oliver, Jack D Chan, Xin Du, Yuchen Bai, Belinda Lee, Ricky W Johnstone, Phillip K Darcy, Michael H Kershaw, Clare Y Slaney

2021-11-01

PURPOSE: In this article, we describe a combination chimeric antigen receptor (CAR) T-cell therapy that eradicated the majority of..

Chimeric antigen receptor T cell therapies for thoracic cancers-challenges and opportunities

Jack D Chan, Aaron J Harrison, Phillip K Darcy, Michael H Kershaw, Clare Y Slaney

2020-08-01

Cross-talk between tumors at anatomically distinct sites

Amanda J Oliver, Phillip K Darcy, Joseph A Trapani, Michael H Kershaw, Clare Y Slaney

2020-04-21

Cancer tissue is not homogenous, and individual metastases at different anatomical locations can differ from the primary tumor and..

Enhancing chimeric antigen receptor T-cell immunotherapy against cancer using a nanoemulsion-based vaccine targeting cross-presenting dendritic cells

Jack D Chan, Bianca von Scheidt, Bijun Zeng, Amanda J Oliver, Ashleigh S Davey, Aesha Ali, Ranjeny Thomas, Joseph A Trapani, Phillip K Darcy, Michael H Kershaw, Riccardo Dolcetti, Clare Y Slaney

2020-01-01

OBJECTIVES: Adoptive transfer of chimeric antigen receptor (CAR)-modified T cells is a form of cancer immunotherapy that has achie..

Primary and metastatic breast tumors cross-talk to influence immunotherapy responses

Amanda J Oliver, Simon P Keam, Bianca von Scheidt, Damien J Zanker, Aaron J Harrison, Daniela GM Tantalo, Phillip K Darcy, Michael H Kershaw, Clare Y Slaney

2020-01-01

The presence of a tumor can alter host immunity systematically. The immune-tumor interaction in one site may impact the local immu..

Enterotoxins can support CAR T cells against solid tumors

Bianca von Scheidt, Minyu Wang, Amanda J Oliver, Jack D Chan, Metta K Jana, Aesha I Ali, Fiona Clow, John D Fraser, Kylie M Quinn, Phillip K Darcy, Michael H Kershaw, Clare Y Slaney

2019-12-10

Responses of solid tumors to chimeric antigen receptor (CAR) T cell therapy are often minimal. This is potentially due to a lack o..

Genetic Redirection of T Cells for the Treatment of Pancreatic Cancer

Aesha I Ali, Amanda J Oliver, Tinaz Samiei, Jack D Chan, Michael H Kershaw, Clare Y Slaney

2019-02-12

Conventional treatments for pancreatic cancer are largely ineffective, and the prognosis for the vast majority of patients is poor..

Tissue-specific tumor microenvironments influence responses to immunotherapies

Amanda J Oliver, Ashleigh S Davey, Simon P Keam, Sherly Mardiana, Jack D Chan, Bianca von Scheidt, Paul A Beavis, Imran G House, Jonas RM Van Audernaerde, Phillip K Darcy, Michael H Kershaw, Clare Y Slaney

2019-01-01

OBJECTIVES: Investigation of variable response rates to cancer immunotherapies has exposed the immunosuppressive tumor microenviro..

CARs versus BiTEs: A Comparison between T Cell-Redirection Strategies for Cancer Treatment

Clare Y Slaney, Pin Wang, Phillip K Darcy, Michael H Kershaw

2018-08-01

The redirection of T cells against tumors holds much promise for the treatment of cancer. Two main approaches for T-cell redirecti..