Grant number: IIRS-18-064 | Funding period: 2018 - 2020
Completed
Aesha Ali, Minyu Wang, Bianca von Scheidt, Pilar M Dominguez, Aaron J Harrison, Daniela GM Tantalo, Jian Kang, Amanda J Oliver, Jack D Chan, Xin Du, Yuchen Bai, Belinda Lee, Ricky W Johnstone, Phillip K Darcy, Michael H Kershaw, Clare Y Slaney
2021-11-01
PURPOSE: In this article, we describe a combination chimeric antigen receptor (CAR) T-cell therapy that eradicated the majority of..
Jack D Chan, Aaron J Harrison, Phillip K Darcy, Michael H Kershaw, Clare Y Slaney
2020-08-01
Amanda J Oliver, Phillip K Darcy, Joseph A Trapani, Michael H Kershaw, Clare Y Slaney
2020-04-21
Cancer tissue is not homogenous, and individual metastases at different anatomical locations can differ from the primary tumor and..
Jack D Chan, Bianca von Scheidt, Bijun Zeng, Amanda J Oliver, Ashleigh S Davey, Aesha Ali, Ranjeny Thomas, Joseph A Trapani, Phillip K Darcy, Michael H Kershaw, Riccardo Dolcetti, Clare Y Slaney
2020-01-01
OBJECTIVES: Adoptive transfer of chimeric antigen receptor (CAR)-modified T cells is a form of cancer immunotherapy that has achie..
Amanda J Oliver, Simon P Keam, Bianca von Scheidt, Damien J Zanker, Aaron J Harrison, Daniela GM Tantalo, Phillip K Darcy, Michael H Kershaw, Clare Y Slaney
The presence of a tumor can alter host immunity systematically. The immune-tumor interaction in one site may impact the local immu..
Bianca von Scheidt, Minyu Wang, Amanda J Oliver, Jack D Chan, Metta K Jana, Aesha I Ali, Fiona Clow, John D Fraser, Kylie M Quinn, Phillip K Darcy, Michael H Kershaw, Clare Y Slaney
2019-12-10
Responses of solid tumors to chimeric antigen receptor (CAR) T cell therapy are often minimal. This is potentially due to a lack o..
Aesha I Ali, Amanda J Oliver, Tinaz Samiei, Jack D Chan, Michael H Kershaw, Clare Y Slaney
2019-02-12
Conventional treatments for pancreatic cancer are largely ineffective, and the prognosis for the vast majority of patients is poor..
Amanda J Oliver, Ashleigh S Davey, Simon P Keam, Sherly Mardiana, Jack D Chan, Bianca von Scheidt, Paul A Beavis, Imran G House, Jonas RM Van Audernaerde, Phillip K Darcy, Michael H Kershaw, Clare Y Slaney
2019-01-01
OBJECTIVES: Investigation of variable response rates to cancer immunotherapies has exposed the immunosuppressive tumor microenviro..
Clare Y Slaney, Pin Wang, Phillip K Darcy, Michael H Kershaw
2018-08-01
The redirection of T cells against tumors holds much promise for the treatment of cancer. Two main approaches for T-cell redirecti..