Multidrug Resistance Protein 1 Inhibitors to Sensitise Cancers to Chemotherapy
Grant number: 1136278 | Funding period: 2018 - 2020
Completed
Abstract
Multidrug resistance protein 1 (MRP1) is often present at high levels in cancer cells, where it pumps chemotherapy drugs back out, causing drug resistance. Inhibitors that block MRP1 would increase the effectiveness of chemotherapy. We have developed MRP1 inhibitors with promising activity in cancer cells and mouse tumours and will now develop these inhibitors for clinical application and commercialisation.