UNDERSTANDING MEDIATORS OF METABOLIC DISEASE
Grant number: 1143224 | Funding period: 2018 - 2021
This research proposal will identify changes in liver-secreted proteins during the development of fatty liver, and in the transition from fatty liver to the more advanced form of liver disease, non-alcoholic steatohepatitis (NASH). Understanding the differences in protein secretion between NASH patients and patients with normal/fatty liver will provide the opportunity to identify disease biomarkers that could be determined from a blood sample. This will provide a major shift in clinical care.
Related publications (8)
Perilipin 5 S155 phosphorylation by PKA is required for the control of hepatic lipid metabolism and glycemic control
Stacey N Keenan, William De Nardo, Jieqiong Lou, Ralf B Schittenhelm, Magdalene K Montgomery, James G Granneman, Elizabeth Hinde, Matthew J Watt
Perilipin 5 (PLIN5) is a lipid-droplet-associated protein that coordinates intracellular lipolysis in highly oxidative tissues and..
SMOC1 is a glucose-responsive hepatokine and therapeutic target for glycemic control
Magdalene K Montgomery, Jacqueline Bayliss, Camille Devereux, Ayenachew Bezawork-Geleta, David Roberts, Cheng Huang, Ralf B Schittenhelm, Andrew Ryan, Scott L Townley, Luke A Selth, Trevor J Biden, Gregory R Steinberg, Dorit Samocha-Bonet, Ruth CR Meex, Matthew J Watt
Intertissue communication is a fundamental feature of metabolic regulation, and the liver is central to this process. We have iden..
Molecular regulators of lipid metabolism in the intestine - Underestimated therapeutic targets for obesity?
Mercedes Davalos-Salas, John M Mariadason, Matthew J Watt, Magdalene K Montgomery
The incidence of obesity and type 2 diabetes continues to rise across the globe necessitating the need to identify new therapeutic..
Inter-organelle Communication in the Pathogenesis of Mitochondrial Dysfunction and Insulin Resistance
Stacey N Keenan, Matthew J Watt, Magdalene K Montgomery
PURPOSE OF REVIEW: Impairments in mitochondrial function in patients with insulin resistance and type 2 diabetes have been dispute..
Perilipin 5 Deletion in Hepatocytes Remodels Lipid Metabolism and Causes Hepatic Insulin Resistance in Mice
Stacey N Keenan, Ruth C Meex, Jennifer CY Lo, Andrew Ryan, Shuai Nie, Magdalene K Montgomery, Matthew J Watt
Defects in hepatic lipid metabolism cause nonalcoholic fatty liver disease and insulin resistance, and these pathologies are close..
Suppressing fatty acid uptake has therapeutic effects in preclinical models of prostate cancer
Matthew J Watt, Ashlee K Clark, Luke A Selth, Vanessa R Haynes, Natalie Lister, Richard Rebello, Laura H Porter, Birunthi Niranjan, Sarah T Whitby, Jennifer Lo, Cheng Huang, Ralf B Schittenhelm, Kimberley E Anderson, Luc Furic, Poornima R Wijayaratne, Maria Matzaris, Magdalene K Montgomery, Melissa Papargiris, Sam Norden, Maria Febbraio
Metabolism alterations are hallmarks of cancer, but the involvement of lipid metabolism in disease progression is unclear. We inve..