UNDERSTANDING MEDIATORS OF METABOLIC DISEASE
Grant number: 1143224 | Funding period: 2018 - 2021
This research proposal will identify changes in liver-secreted proteins during the development of fatty liver, and in the transition from fatty liver to the more advanced form of liver disease, non-alcoholic steatohepatitis (NASH). Understanding the differences in protein secretion between NASH patients and patients with normal/fatty liver will provide the opportunity to identify disease biomarkers that could be determined from a blood sample. This will provide a major shift in clinical care.
Related publications (16)
Investigating dual inhibition of ACC and CD36 for the treatment of nonalcoholic fatty liver disease in mice.
Camille J Devereux, Jacqueline Bayliss, Stacey N Keenan, Magdalene K Montgomery, Matthew J Watt
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide. Dysregulation in hepatic lipid metabo..
Proteomic analysis reveals exercise training induced remodelling of hepatokine secretion and uncovers syndecan-4 as a regulator of hepatic lipid metabolism
William De Nardo, Paula M Miotto, Jacqueline Bayliss, Shuai Nie, Stacey N Keenan, Magdalene K Montgomery, Matthew J Watt
OBJECTIVE: Non-alcoholic fatty liver disease (NAFLD) is linked to impaired lipid metabolism and systemic insulin resistance, which..
Deep proteomic profiling unveils arylsulfatase A as a non-alcoholic steatohepatitis inducible hepatokine and regulator of glycemic control
Magdalene K Montgomery, Jacqueline Bayliss, Shuai Nie, William De Nardo, Stacey N Keenan, Paula M Miotto, Hamzeh Karimkhanloo, Cheng Huang, Ralf B Schittenhelm, Anthony S Don, Andrew Ryan, Nicholas A Williamson, Geraldine J Ooi, Wendy A Brown, Paul R Burton, Benjamin L Parker, Matthew J Watt
Non-alcoholic steatohepatitis (NASH) and type 2 diabetes are closely linked, yet the pathophysiological mechanisms underpinning th..
Hexosaminidase A (HEXA) regulates hepatic sphingolipid and lipoprotein metabolism in mice
Magdalene K Montgomery, Amanuiel Z Taddese, Jacqueline Bayliss, Shuai Nie, Nicholas A Williamson, Matthew J Watt
Hexosaminidase A (HexA), a heterodimer consisting of HEXA and HEXB, converts the ganglioside sphingolipid GM2 to GM3 by removing a..
Ectodysplasin A Is Increased in Non-Alcoholic Fatty Liver Disease, But Is Not Associated With Type 2 Diabetes
Jacqueline Bayliss, Geraldine J Ooi, William De Nardo, Yazmin Johari Halim Shah, Magdalene K Montgomery, Catriona McLean, William Kemp, Stuart K Roberts, Wendy A Brown, Paul R Burton, Matthew J Watt
UNLABELLED: Ectodysplasin A (EDA) was recently identified as a liver-secreted protein that is increased in the liver and plasma of..
Perilipin 5 S155 phosphorylation by PKA is required for the control of hepatic lipid metabolism and glycemic control
Stacey N Keenan, William De Nardo, Jieqiong Lou, Ralf B Schittenhelm, Magdalene K Montgomery, James G Granneman, Elizabeth Hinde, Matthew J Watt
Perilipin 5 (PLIN5) is a lipid-droplet-associated protein that coordinates intracellular lipolysis in highly oxidative tissues and..
Epicardial Adipose Tissue Accumulation Confers Atrial Conduction Abnormality
Chrishan J Nalliah, James R Bell, Antonia JA Raaijmakers, Helen M Waddell, Simon P Wells, Gabriel B Bernasochi, Magdalene K Montgomery, Simon Binny, Troy Watts, Subodh B Joshi, Elaine Lui, Choon Boon Sim, Marco Larobina, Michael O'Keefe, John Goldblatt, Alistair Royse, Geoffrey Lee, Enzo R Porrello, Matthew J Watt, Peter M Kistler
BACKGROUND: Clinical studies have reported that epicardial adipose tissue (EpAT) accumulation associates with the progression of a..
SMOC1 is a glucose-responsive hepatokine and therapeutic target for glycemic control
Magdalene K Montgomery, Jacqueline Bayliss, Camille Devereux, Ayenachew Bezawork-Geleta, David Roberts, Cheng Huang, Ralf B Schittenhelm, Andrew Ryan, Scott L Townley, Luke A Selth, Trevor J Biden, Gregory R Steinberg, Dorit Samocha-Bonet, Ruth CR Meex, Matthew J Watt
Intertissue communication is a fundamental feature of metabolic regulation, and the liver is central to this process. We have iden..
Molecular regulators of lipid metabolism in the intestine - Underestimated therapeutic targets for obesity?
Mercedes Davalos-Salas, John M Mariadason, Matthew J Watt, Magdalene K Montgomery
The incidence of obesity and type 2 diabetes continues to rise across the globe necessitating the need to identify new therapeutic..
Inter-organelle Communication in the Pathogenesis of Mitochondrial Dysfunction and Insulin Resistance
Stacey N Keenan, Matthew J Watt, Magdalene K Montgomery
PURPOSE OF REVIEW: Impairments in mitochondrial function in patients with insulin resistance and type 2 diabetes have been dispute..
The role of Ap2a2 in PPAR alpha-mediated regulation of lipolysis in adipose tissue
Magdalene K Montgomery, Jacqueline Bayliss, Stacey Keenan, Sarah Rhost, Stephen B Ting, Matthew J Watt
Adipose tissue plays a major role in the regulation of systemic metabolic homeostasis, with the AP2 adaptor complex being importan..
Perilipin 5 Deletion in Hepatocytes Remodels Lipid Metabolism and Causes Hepatic Insulin Resistance in Mice
Stacey N Keenan, Ruth C Meex, Jennifer CY Lo, Andrew Ryan, Shuai Nie, Magdalene K Montgomery, Matthew J Watt
Defects in hepatic lipid metabolism cause nonalcoholic fatty liver disease and insulin resistance, and these pathologies are close..
Suppressing fatty acid uptake has therapeutic effects in preclinical models of prostate cancer
Matthew J Watt, Ashlee K Clark, Luke A Selth, Vanessa R Haynes, Natalie Lister, Richard Rebello, Laura H Porter, Birunthi Niranjan, Sarah T Whitby, Jennifer Lo, Cheng Huang, Ralf B Schittenhelm, Kimberley E Anderson, Luc Furic, Poornima R Wijayaratne, Maria Matzaris, Magdalene K Montgomery, Melissa Papargiris, Sam Norden, Maria Febbraio
Metabolism alterations are hallmarks of cancer, but the involvement of lipid metabolism in disease progression is unclear. We inve..