Investigating a Novel Anti-Cancer Drug in Comination With Immunotherapy to Treat Breast Cancer

Intracellular zinc protects tumours from T cell-mediated cytotoxicity

EJ Lelliott, J Naddaf, K Ganio, J Michie, S Wang, L Liu, N Silke, A Ahn, KM Ramsbottom, AJ Brennan, AJ Freeman, S Goel, SJ Vervoort, CJ Kearney, PA Beavis, CA McDevitt, J Silke, J Oliaro

2024-12-01

Tumour immune evasion presents a significant challenge to the effectiveness of cancer immunotherapies. Recent advances in high-thr..

NKG7 Enhances CD8 T Cell Synapse Efficiency to Limit Inflammation

EJ Lelliott, KM Ramsbottom, MR Dowling, C Shembrey, T Noori, CJ Kearney, J Michie, IA Parish, MA Jordan, AG Baxter, ND Young, AJ Brennan, J Oliaro

2022-07-06

Cytotoxic lymphocytes are essential for anti-tumor immunity, and for effective responses to cancer immunotherapy. Natural killer c..

Unleashing TNF cytotoxicity to enhance cancer immunotherapy

AJ Freeman, CJ Kearney, J Silke, J Oliaro

2021-12-01

Tumor necrosis factor (TNF) is a proinflammatory cytokine that is produced and secreted by cytotoxic lymphocytes upon tumor target..

HOIP limits anti-tumor immunity by protecting against combined TNF and IFN-gamma-induced apoptosis

AJ Freeman, SJ Vervoort, J Michie, KM Ramsbottom, J Silke, CJ Kearney, J Oliaro

2021-11-04

The success of cancer immunotherapy is limited to a subset of patients, highlighting the need to identify the processes by which t..

CDK4/6 inhibition promotes antitumor immunity through the induction of T-cell memory

EJ Lelliott, IY Kong, M Zethoven, KM Ramsbottom, LG Martelotto, D Meyran, JJ Zhu, M Costacurta, L Kirby, JJ Sandow, L Lim, PM Dominguez, I Todorovski, NM Haynes, PA Beavis, PJ Neeson, ED Hawkins, GA McArthur, IA Parish, RW Johnstone

2021-10-01

Pharmacologic inhibitors of cyclin-dependent kinases 4 and 6 (CDK4/6) are an approved treatment for hormone receptor–positive brea..

Immunomodulatory Effects of BRAF, MEK, and CDK4/6 Inhibitors: Implications for Combining Targeted Therapy and Immune Checkpoint Blockade for the Treatment of Melanoma

EJ Lelliott, GA McArthur, J Oliaro, KE Sheppard

2021-05-07

The recent advent of targeted and immune-based therapies has revolutionized the treatment of melanoma and transformed outcomes for..

SUGAR-seq enables simultaneous detection of glycans, epitopes, and the transcriptome in single cells

CJ Kearney, SJ Vervoort, KM Ramsbottom, I Todorovski, EJ Lelliott, M Zethoven, L Pijpers, BP Martin, T Semple, L Martelotto, JA Trapani, IA Parish, NE Scott, J Oliaro, RW Johnstone

2021-02-19

Multimodal single-cell RNA sequencing enables the precise mapping of transcriptional and phenotypic features of cellular different..

Combined BRAF, MEK, and CDK4/6 inhibition depletes intratumoral immune-potentiating myeloid populations in Melanoma

EJ Lelliott, S Mangiola, KM Ramsbottom, M Zethoven, L Lim, PKH Lau, AJ Oliver, LG Martelotto, L Kirby, C Martin, RP Patel, A Slater, C Cullinane, AT Papenfuss, NM Haynes, GA McArthur, J Oliaro, KE Sheppard

2021-02-01

Combined inhibition of BRAF, MEK, and CDK4/6 is currently under evaluation in clinical trials for patients with melanoma harboring..

Inhibition of tumor autophagy: a strategy to improve anti-tumor immunity?

AJ Freeman, EJ Lelliott, J Oliaro

2020-12-01

The Immuno-Modulatory Effects of Inhibitor of Apoptosis Protein Antagonists in Cancer Immunotherapy

Jessica Michie, Conor Kearney, Edwin D Hawkins, John Silke, Jane Oliaro

2020-01-14

One of the hallmarks of cancer cells is their ability to evade cell death via apoptosis. The inhibitor of apoptosis proteins (IAPs..

Natural Killer Cells Suppress T Cell-Associated Tumor Immune Evasion

AJ Freeman, SJ Vervoort, KM Ramsbottom, MJ Kelly, J Michie, L Pijpers, RW Johnstone, CJ Kearney, J Oliaro

2019-09-10

Freeman et al. use a series of genome-wide loss-of-function genetic screens to identify genes that limit tumor sensitivity to kill..

Antagonism of IAPs enhances CAR T-cell efficacy

J Michie, PA Beavis, AJ Freeman, SJ Vervoort, KM Ramsbottom, V Narasimhan, EJ Lelliott, N Lalaoui, RG Ramsay, RW Johnstone, J Silke, PK Darcy, I Voskoboinik, CJ Kearney, J Oliaro

2019-02-01

Chimeric antigen receptor (CAR) T-cell therapy has proven successful in the treatment of hematological malignancies, notably acute..