Grant number: 2U01CA167551-07 | Funding period: 2018 - 2023
Active
Xiaoliang Wang, Efrat Amitay, Tabitha A Harrison, Barbara L Banbury, Sonja I Berndt, Hermann Brenner, Daniel D Buchanan, Peter T Campbell, Yin Cao, Andrew T Chan, Jenny Chang-Claude, Steven J Gallinger, Marios Giannakis, Graham G Giles, Marc J Gunter, John L Hopper, Mark A Jenkins, Yi Lin, Victor Moreno, Reiko Nishihara
2021-08-01
Background: Smoking is associated with colorectal cancer (CRC) risk. Previous studies suggested this association may be restricted..
Xinwei Hua, James Y Dai, Sara Lindstrom, Tabitha A Harrison, Yi Lin, Steven R Alberts, Elizabeth Alwers, Sonja Berndt, Hermann Brenner, Daniel D Buchanan, Peter T Campbell, Graham Casey, Jenny Chang-Claude, Steven Gallinger, Graham G Giles, Richard M Goldberg, Marc J Gunter, Michael Hoffmeister, Mark A Jenkins, Amit D Joshi
2021-07-01
BACKGROUND: A positive association between circulating C-reactive protein (CRP) and colorectal cancer survival was reported in obs..
Sabine Meessen, Nicola Currey, Zeenat Jahan, Hannah W Parker, Mark A Jenkins, Daniel D Buchanan, John L Hopper, Eva Segelov, Jane E Dahlstrom, Maija RJ Kohonen-Corish
MSH3 gene or protein deficiency or loss-of-function in colorectal cancer can cause a DNA mismatch repair defect known as "elevated..
Mark A Jenkins
BACKGROUND: Existing clinical practice guidelines for carriers of pathogenic variants of DNA mismatch repair genes (Lynch syndrome..
Alexi N Archambault, Yi Lin, Jihyoun Jeon, Tabitha A Harrison, D Timothy Bishop, Hermann Brenner, Graham Casey, Andrew T Chan, Jenny Chang-Claude, Jane C Figueiredo, Steven Gallinger, Stephen B Gruber, Marc J Gunter, Michael Hoffmeister, Mark A Jenkins, Temitope O Keku, Loic Le Marchand, Li Li, Victor Moreno, Polly A Newcomb
2021-06-01
Background: Incidence of early-onset (younger than 50 years of age) colorectal cancer (CRC) is increasing in many countries. Thus,..
Niki Dimou, James Yarmolinsky, Emmanouil Bouras, Konstantinos K Tsilidis, Richard M Martin, Sarah J Lewis, Inger T Gram, Marije F Bakker, Hermann Brenner, Jane C Figueiredo, Renee T Fortner, Stephen B Gruber, Bethany van Guelpen, Li Hsu, Rudolf Kaaks, Sun-Seog Kweon, Yi Lin, Noralane M Lindor, Polly A Newcomb, Maria-Jose Sanchez
2021-05-01
BACKGROUND: Observational evidence has shown that smoking is a risk factor for breast and colorectal cancer. We used Mendelian ran..
Marco Matejcic, Hiba A Shaban, Melanie W Quintana, Fredrick R Schumacher, Christopher K Edlund, Leah Naghi, Rish K Pai, Robert W Haile, A Joan Levine, Daniel D Buchanan, Mark A Jenkins, Jane C Figueiredo, Gad Rennert, Stephen B Gruber, Li Li, Graham Casey, David Conti, Stephanie L Schmit
BACKGROUND: Inherited susceptibility is an important contributor to colorectal cancer risk, and rare variants in key genes or path..
Mark A Jenkins, Daniel D Buchanan, John Lai, Enes Makalic, Gillian S Dite, Aung K Win, Mark Clendenning, Ingrid M Winship, Richard B Hayes, Jeroen R Huyghe, Ulrike Peters, Steven Gallinger, Loic Le Marchand, Jane C Figueiredo, Rish K Pai, Polly A Newcomb, James M Church, Graham Casey, John L Hopper
2021-04-01
It was not known whether the polygenic risk scores (PRSs) that predict colorectal cancer could predict colorectal cancer for peopl..
Aayah Nounu, Alexander Greenhough, Kate J Heesom, Rebecca C Richmond, Jie Zheng, Stephanie J Weinstein, Demetrius Albanes, John A Baron, John L Hopper, Jane C Figueiredo, Polly A Newcomb, Noralane M Lindor, Graham Casey, Elizabeth A Platz, Loic Le Marchand, Cornelia M Ulrich, Christopher Li, Franzel JB van Duijnhoven, Andrea Gsur, Peter T Campbell
2021-03-01
BACKGROUND: Evidence for aspirin's chemopreventative properties on colorectal cancer (CRC) is substantial, but its mechanism of ac..
Xingyi Guo, Weiqiang Lin, Wanqing Wen, Jeroen Huyghe, Stephanie Bien, Qiuyin Cai, Tabitha Harrison, Zhishan Chen, Conghui Qu, Jiandong Bao, Jirong Long, Yuan Yuan, Fangqin Wang, Mengqiu Bai, Goncalo R Abecasis, Demetrius Albanes, Sonja Berndt, Stephane Bezieau, D Timothy Bishop, Hermann Brenner
BACKGROUND AND AIMS: Susceptibility genes and the underlying mechanisms for the majority of risk loci identified by genome-wide as..
Jesca GM Brouwer, Polly A Newcomb, Tanya M Bisseling, Jane C Figueiredo, John L Hopper, Mark A Jenkins, Jan J Koornstra, Noralane M Lindor, Hans FA Vasen, Aung K Win, Ellen Kampman, Franzel JB van Duijnhoven
2021-02-01
Persons with Lynch syndrome (LS - carrying a pathogenic mutation in a DNA mismatch repair gene) have an increased colorectal cance..
Peter Georgeson, Bernard J Pope, Christophe Rosty, Mark Clendenning, Khalid Mahmood, Jihoon E Joo, Romy Walker, Ryan A Hutchinson, Susan Preston, Julia Como, Sharelle Joseland, Aung Ko Win, Finlay A Macrae, John L Hopper, Dmitri Mouradov, Peter Gibbs, Oliver M Sieber, Dylan E O'Sullivan, Darren R Brenner, Steve Gallinger
2021-01-07
OBJECTIVE: Germline pathogenic variants (PVs) in the DNA mismatch repair (MMR) genes and in the base excision repair gene MUTYH un..
Richard Culliford, Alex J Cornish, Philip J Law, Susan M Farrington, Kimmo Palin, Mark A Jenkins, Graham Casey, Michael Hoffmeister, Hermann Brenner, Jenny Chang-Claude, Iva Kirac, Tim Maughan, Stefanie Brezina, Andrea Gsur, Jeremy P Cheadle, Lauri A Aaltonen, Malcom G Dunlop, Richard S Houlston
BACKGROUND: Epidemiological studies of the relationship between gallstone disease and circulating levels of bilirubin with risk of..
Peter T Campbell, Yi Lin, Stephanie A Bien, Jane C Figueiredo, Tabitha A Harrison, Mark A Guinter, Sonja Berndt, Hermann Brenner, Andrew T Chan, Jenny Chang-Claude, Steven J Gallinger, Susan M Gapstur, Graham G Giles, Edward Giovannucci, Stephen B Gruber, Marc Gunter, Michael Hoffmeister, Eric J Jacobs, Mark A Jenkins, Loic Le Marchand
2021-01-01
BACKGROUND: Body mass index (BMI) is a complex phenotype that may interact with genetic variants to influence colorectal cancer ri..
Caroline J Bull, Joshua A Bell, Neil Murphy, Eleanor Sanderson, George Davey Smith, Nicholas J Timpson, Barbara L Banbury, Demetrius Albanes, Sonja I Berndt, Stephane Bezieau, D Timothy Bishop, Hermann Brenner, Daniel D Buchanan, Andrea Burnett-Hartman, Graham Casey, Sergi Castellvi-Bel, Andrew T Chan, Jenny Chang-Claude, Amanda J Cross, Albert de la Chapelle
2020-12-17
BACKGROUND: Higher adiposity increases the risk of colorectal cancer (CRC), but whether this relationship varies by anatomical sub..
Sonja Neumeyer, Xinwei Hua, Petra Seibold, Lina Jansen, Axel Benner, Barbara Burwinkel, Niels Halama, Sonja I Berndt, Amanda I Phipps, Lori C Sakoda, Robert E Schoen, Martha L Slattery, Andrew T Chan, Manish Gala, Amit D Joshi, Shuji Ogino, Mingyang Song, Esther Herpel, Hendrik Blaker, Matthias Kloor
2020-12-01
BACKGROUND: High numbers of lymphocytes in tumor tissue, including T regulatory cells (Treg), have been associated with better col..
Fadwa A Elsayed, Judith E Grolleman, Abiramy Ragunathan, Daniel D Buchanan, Tom van Wezel, Richarda M de Voer
Akihisa Hidaka, Tabitha A Harrison, Yin Cao, Lori C Sakoda, Richard Barfield, Marios Giannakis, Mingyang Song, Amanda Phipps, Jane C Figueiredo, Syed H Zaidi, Amanda E Toland, Efrat L Amitay, Sonja Berndt, Ivan Borozan, Andrew T Chan, Steven Gallinger, Marc J Gunter, Mark A Guinter, Sophia Harlid, Heather Hampel
2020-10-15
Protective associations of fruits, vegetables, and fiber intake with colorectal cancer risk have been shown in many, but not all e..
Julia D Labadie, Tabitha A Harrison, Barbara Banbury, Efrat L Amtay, Sonja Bernd, Hermann Brenner, Daniel D Buchanan, Peter T Campbell, Yin Cao, Andrew T Chan, Jenny Chang-Claude, Dallas English, Jane C Figueiredo, Steven J Gallinger, Graham G Giles, Marc J Gunter, Michael Hoffmeister, Li Hsu, Mark A Jenkins, Yi Lin
2020-10-01
Background: Postmenopausal hormone therapy (HT) is associated with a decreased colorectal cancer (CRC) risk. As CRC is a heterogen..
Sibel Saya, Jon D Emery, James G Dowty, Jennifer G McIntosh, Ingrid M Winship, Mark A Jenkins
Background In many countries, population colorectal cancer (CRC) screening is based on age and family history, though more precise..
Nazlisadat Seyed Khoei, Mazda Jenab, Neil Murphy, Barbara L Banbury, Robert Carreras-Torres, Vivian Viallon, Tilman Kuehn, Bas Bueno-de-Mesquita, Krasimira Aleksandrova, Amanda J Cross, Elisabete Weiderpass, Magdalena Stepien, Andrew Bulmer, Anne Tjonneland, Marie-Christine Boutron-Ruault, Gianluca Severi, Franck Carbonnel, Verena Katzke, Heiner Boeing, Manuela M Bergmann
2020-09-03
BACKGROUND: Bilirubin, a byproduct of hemoglobin breakdown and purported anti-oxidant, is thought to be cancer preventive. We cond..
Minta Thomas, Lori C Sakoda, Michael Hoffmeister, Elisabeth A Rosenthal, Jeffrey K Lee, Franzel JB van Duijnhoven, Elizabeth A Platz, Anna H Wu, Christopher H Dampier, Albert de la Chapelle, Alicja Wolk, Amit D Joshi, Andrea Burnett-Hartman, Andrea Gsur, Annika Lindblom, Antoni Castells, Aung Ko Win, Bahram Namjou, Bethany Van Guelpen, Catherine M Tangen
Accurate colorectal cancer (CRC) risk prediction models are critical for identifying individuals at low and high risk of developin..
Xiaoliang Wang, Yu-Ru Su, Paneen S Petersen, Stephanie Bien, Stephanie L Schmit, David A Drew, Demetrius Albanes, Sonja Berndt, Hermann Brenner, Peter T Campbell, Graham Casey, Jenny Cheng-Claude, Steven Gallinger, Stephen B Gruber, Robert W Haile, Tabitha A Harrison, Michael Hoffmeister, Eric J Jacobs, Mark A Jenkins, Amit D Joshi
2020-09-01
BACKGROUND: Regular use of nonsteroidal anti-inflammatory drugs (NSAID) is associated with lower risk of colorectal cancer. Genome..
Xinyuan Dong, Yu-Ru Su, Richard Barfield, Stephanie A Bien, Qianchuan He, Tabitha A Harrison, Jeroen R Huyghe, Temitope O Keku, Noralane M Lindor, Clemens Schafmayer, Andrew T Chan, Stephen B Gruber, Mark A Jenkins, Charles Kooperberg, Ulrike Peters, Li Hsu
2020-08-01
Genome-wide association studies (GWAS) have successfully identified tens of thousands of genetic variants associated with various ..
Syed H Zaidi, Tabitha A Harrison, Amanda Phipps, Robert Steinfelder, Quang M Trinh, Conghui Qu, Barbara L Banbury, Peter Georgeson, Catherine S Grasso, Marios Giannakis, Jeremy B Adams, Elizabeth Alwers, Efrat L Amitay, Richard T Barfield, Sonja Berndt, Ivan Borozan, Hermann Brenner, Stefanie Brezina, Daniel D Buchanan, Yin Cao
2020-07-20
Colorectal cancer (CRC) is a biologically heterogeneous disease. To characterize its mutational profile, we conduct targeted seque..
Yan Dora Zhang, Amber N Hurson, Haoyu Zhang, Parichoy Pal Choudhury, Douglas F Easton, Roger L Milne, Jacques Simard, Per Hall, Kyriaki Michailidou, Joe Dennis, Marjanka K Schmidt, Jenny Chang-Claude, Puya Gharahkhani, David Whiteman, Peter T Campbell, Michael Hoffmeister, Mark Jenkins, Ulrike Peters, Li Hsu, Stephen B Gruber
2020-07-03
Genome-wide association studies (GWAS) have led to the identification of hundreds of susceptibility loci across cancers, but the i..
Amanda Phipps, Elizabeth Alwers, Tabitha Harrison, Barbara Banbury, Hermann Brenner, Peter T Campbell, Jenny Chang-Claude, Daniel Buchanan, Andrew T Chan, Alton B Farris, Jane C Figueiredo, Steven Gallinger, Graham G Giles, Mark Jenkins, Roger L Milne, Polly A Newcomb, Martha L Slattery, Mingyang Song, Shuji Ogino, Syed H Zaidi
2020-06-01
BACKGROUND AND AIMS: The heterogeneity among colorectal tumors is probably due to differences in developmental pathways and might ..
Samir Gupta, Balambal Bharti, Dennis J Ahnen, Daniel D Buchanan, Iona C Cheng, Michelle Cotterchio, Jane C Figueiredo, Steven J Gallinger, Robert W Haile, Mark A Jenkins, Noralane M Lindor, Finlay A Macrae, Loic Le Marchand, Polly A Newcomb, Stephen N Thibodeau, Aung Ko Win, Maria Elena Martinez
2020-04-20
BACKGROUND: Initiating screening at an earlier age based on cancer family history is one of the primary recommended strategies for..
Neil Murphy, Robert Carreras-Torres, Mingyang Song, Andrew T Chan, Richard M Martin, Nikos Papadimitriou, Niki Dimou, Konstantinos K Tsilidis, Barbara Banbury, Kathryn E Bradbury, Jelena Besevic, Sabina Rinaldi, Elio Riboli, Amanda J Cross, Ruth C Travis, Claudia Agnoli, Demetrius Albanes, Sonja I Berndt, Stephane Bezieau, D Timothy Bishop
2020-04-01
BACKGROUND & AIMS: Human studies examining associations between circulating levels of insulin-like growth factor 1 (IGF1) and insu..
Alexi N Archambault, Yu-Ru Su, Jihyoun Jeon, Minta Thomas, Yi Lin, David V Conti, Aung Ko Win, Lori C Sakoda, Iris Lansdorp-Vogelaar, Elisabeth FP Peterse, Ann G Zauber, David Duggan, Andreana N Holowatyj, Jeroen R Huyghe, Hermann Brenner, Michelle Cotterchio, Stephane Bezieau, Stephanie L Schmit, Christopher K Edlund, Melissa C Southey
BACKGROUND & AIMS: Early-onset colorectal cancer (CRC, in persons younger than 50 years old) is increasing in incidence; yet, in t..
Nikhil K Khankari, Barbara L Banbury, Maria C Borges, Philip Haycock, Demetrius Albanes, Volker Arndt, Sonja I Berndt, Stephane Bezieau, Hermann Brenner, Peter T Campbell, Graham Casey, Andrew T Chan, Jenny Chang-Claude, David V Conti, Michelle Cotterchio, Dallas R English, Jane C Figueiredo, Graham G Giles, Edward L Giovannucci, Marc J Gunter
BACKGROUND: Results from epidemiologic studies examining polyunsaturated fatty acids (PUFA) and colorectal cancer risk are inconsi..
Zhiyu Xia, Yu-Ru Su, Paneen Petersen, Lihong Qi, Andre E Kim, Jane C Figueiredo, Yi Lin, Hongmei Nan, Lori C Sakoda, Demetrius Albanes, Sonja I Berndt, Stephane Bezieau, Stephanie Bien, Daniel D Buchanan, Graham Casey, Andrew T Chan, David V Conti, David A Drew, Steven J Gallinger, W James Gauderman
2020-03-24
BACKGROUND: Body mass index (BMI) and diabetes are established risk factors for colorectal cancer (CRC), likely through perturbati..
Sonja Neumeyer, Katja Butterbach, Barbara L Banbury, Sonja I Berndt, Peter T Campbell, Rowan T Chlebowski, Andrew T Chan, Edward L Giovannucci, Amit D Joshi, Shuji Ogino, Mingyang Song, Marjorie L McCullough, Haifa Maalmi, JoAnn E Manson, Lori C Sakoda, Robert E Schoen, Martha L Slattery, Emily White, Aung K Win, Jane C Figueiredo
2020-03-18
Background: Low serum 25-hydroxyvitamin D [25(OH)D] concentrations in patients with colorectal cancer have been consistently assoc..
Yingye Zheng, Xinwei Hua, Aung K Win, Robert J MacInnis, Steven Gallinger, Loic Le Marchand, Noralane M Lindor, John A Baron, John L Hopper, James G Dowty, Antonis C Antoniou, Jiayin Zheng, Mark A Jenkins, Polly A Newcomb
2020-03-01
PURPOSE: Reducing colorectal cancer incidence and mortality through early detection would improve efficacy if targeted. We develop..
Shimelis Dejene Gemechu, Christine M van Vliet, Aung Ko Win, Jane C Figueiredo, Loic Le Marchand, Steven Gallinger, Polly A Newcomb, John L Hopper, Noralane M Lindor, Mark A Jenkins, James G Dowty
2020-02-27
Individuals who carry pathogenic mutations in DNA mismatch repair (MMR) genes have high risks of cancer, and small studies have su..
Nikos Papadimitriou, Niki Dimou, Konstantinos K Tsilidis, Barbara Banbury, Richard M Martin, Sarah J Lewis, Nabila Kazmi, Timothy M Robinson, Demetrius Albanes, Krasimira Aleksandrova, Sonja I Berndt, D Timothy Bishop, Hermann Brenner, Daniel D Buchanan, Bas Bueno-de-Mesquita, Peter T Campbell, Sergi Castellvi-Bel, Andrew T Chan, Jenny Chang-Claude, Merete Ellingjord-Dale
2020-01-30
Physical activity has been associated with lower risks of breast and colorectal cancer in epidemiological studies; however, it is ..
Barbara Pardini, Alda Corrado, Elisa Paolicchi, Giovanni Cugliari, Sonja Berndt, Stephane Bezieau, Stephanie A Bien, Hermann Brenner, Bette J Caan, Peter T Campbell, Graham Casey, Andrew T Chan, Jenny Chang-Claude, Michelle Cotterchio, Manish Gala, Steven J Gallinger, Robert W Haile, Tabitha A Harrison, Richard B Hayes, Michael Hoffmeister
2020-01-15
Interindividual differences in DNA repair systems may play a role in modulating the individual risk of developing colorectal cance..
Mev Dominguez-Valentin, Julian R Sampson, Toni T Seppala, Sanne W ten Broeke, John-Paul Plazzer, Sigve Nakken, Christoph Engel, Stefan Aretz, Mark A Jenkins, Lone Sunde, Inge Bernstein, Gabriel Capella, Francesc Balaguer, Huw Thomas, D Gareth Evans, John Burn, Marc Greenblatt, Eivind Hovig, Wouter H de Vos Tot Nederveen Cappel, Rolf H Sijmons
2020-01-01
PURPOSE: Pathogenic variants affecting MLH1, MSH2, MSH6, and PMS2 cause Lynch syndrome and result in different but imprecisely kno..
Bryony A Thompson, Rhiannon Walters, Michael T Parsons, Troy Dumenil, Mark Drost, Yvonne Tiersma, Noralane M Lindor, Sean V Tavtigian, Niels de Wind, Amanda B Spurdle, null InSiGHT Variant Interpretation Committee
Functional assays that assess mRNA splicing can be used in interpretation of the clinical significance of sequence variants, inclu..
Alex J Cornish, Philip J Law, Maria Timofeeva, Kimmo Palin, Susan M Farrington, Claire Palles, Mark A Jenkins, Graham Casey, Hermann Brenner, Jenny Chang-Claude, Michael Hoffmeister, Iva Kirac, Tim Maughan, Stefanie Brezina, Andrea Gsur, Jeremy P Cheadle, Lauri A Aaltonen, Ian Tomlinson, Malcolm G Dunlop, Richard S Houlston
BACKGROUND: Epidemiological studies have linked lifestyle, cardiometabolic, reproductive, developmental, and inflammatory factors ..
Zahra Montazeri, Xue Li, Christine Nyiraneza, Xiangyu Ma, Maria Timofeeva, Victoria Svinti, Xiangrui Meng, Yazhou He, Yacong Bo, Samuel Morgan, Sergi Castellví-Bel, Clara Ruiz-Ponte, Ceres Fernández-Rozadilla, Ángel Carracedo, Antoni Castells, Timothy Bishop, Daniel Buchanan, Mark A Jenkins, Temitope O Keku, Annika Lindblom
2019-12-09
OBJECTIVE: To provide an understanding of the role of common genetic variations in colorectal cancer (CRC) risk, we report an upda..
S Ghazaleh Dashti, Wing Yan Li, Daniel D Buchanan, Mark Clendenning, Christophe Rosty, Ingrid M Winship, Finlay A Macrae, Graham G Giles, Sheetal Hardikar, Xinwei Hua, Stephen N Thibodeau, Jane C Figueiredo, Graham Casey, Robert W Haile, Steven Gallinger, Loic Le Marchand, Polly A Newcomb, John D Potter, Noralane M Lindor, John L Hopper
2019-11-12
BACKGROUND: Type 2 diabetes mellitus and high total cholesterol and triglycerides are known to be associated with increased colore..
Mark A Jenkins, Aung K Win, James G Dowty, Robert J MacInnis, Enes Makalic, Daniel F Schmidt, Gillian S Dite, Mirosl Kapuscinski, Mark Clendenning, Christophe Rosty, Ingrid M Winship, Jon D Emery, Sibel Saya, Finlay A Macrae, Dennis J Ahnen, David Duggan, Jane C Figueiredo, Noralane M Lindor, Robert W Haile, John D Potter
2019-10-01
Before SNP-based risk can be incorporated in colorectal cancer (CRC) screening, the ability of these SNPs to estimate CRC risk for..
Yun-Hee Choi, Lajmi Lakhal-Chaieb, Agnieszka Krol, Bing Yu, Daniel Buchanan, Dennis Ahnen, Loic Le Marchand, Polly A Newcomb, Aung Ko Win, Mark Jenkins, Noralane M Lindor, Laurent Briollais
2019-07-01
BACKGROUND: The risk of cancers is well characterized in Lynch syndrome (LS) families but has been less studied in familial colore..
Peter Georgeson, Michael D Walsh, Mark Clendenning, Simin Daneshvar, Bernard J Pope, Khalid Mahmood, Jihoon E Joo, Harindra Jayasekara, Mark A Jenkins, Ingrid M Winship, Daniel D Buchanan
BACKGROUND: Muir-Torre syndrome is defined by the development of sebaceous skin lesions in individuals who carry a germline mismat..
Marzieh Araghi, Isabelle Soerjomataram, Mark Jenkins, James Brierley, Eva Morris, Freddie Bray, Melina Arnold
2019-06-15
Colorectal cancer (CRC) is the third most common cancer worldwide and the fourth most common cause of cancer death. Predictions of..
Xiaoliang Wang, James Y Dai, Demetrius Albanes, Volker Arndt, Sonja I Berndt, Stephane Bezieau, Hermann Brenner, Daniel D Buchanan, Katja Butterbach, Bette Caan, Graham Casey, Peter T Campbell, Andrew T Chan, Zhengyi Chen, Jenny Chang-Claude, Michelle Cotterchio, Douglas F Easton, Graham G Giles, Edward Giovannucci, William M Grady
2019-06-01
BACKGROUND: Chronic inflammation is a risk factor for colorectal cancer (CRC). Circulating C-reactive protein (CRP) is also modera..
Philip J Law, Maria Timofeeva, Ceres Fernandez-Rozadilla, Aria Timofeeva, Peter Broderick, James Studd, Juan Fernandez-Tajes, Susan Farrington, Victoria Svinti, Claire Palles, Giulia Orlando, Amit Sud, Amy Holroyd, Steven Penegar, Evropi Theodoratou, Peter Vaughan-Shaw, Harry Campbell, Lina Zgaga, Caroline Hayward, Archie Campbell
2019-05-14
Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide, and has a strong heritable basis. We report a genome..
Stephanie A Bien, Yu-Ru Su, David V Conti, Tabitha A Harrison, Conghui Qu, Xingyi Guo, Yingchang Lu, Demetrius Albanes, Paul L Auer, Barbara L Banbury, Sonja I Berndt, Stephane Bezieau, Hermann Brenner, Daniel D Buchanan, Bette J Caan, Peter T Campbell, Christopher S Carlson, Andrew T Chan, Jenny Chang-Claude, Sai Chen
2019-04-01
Genome-wide association studies have reported 56 independently associated colorectal cancer (CRC) risk variants, most of which are..
Yingchang Lu, Sun-Seog Kweon, Chizu Tanikawa, Wei-Hua Jia, Yong-Bing Xiang, Qiuyin Cai, Chenjie Zeng, Stephanie L Schmit, Aesun Shin, Keitaro Matsuo, Sun Ha Jee, Dong-Hyun Kim, Jeongseon Kim, Wanqing Wen, Jiajun Shi, Xingyi Guo, Bingshan Li, Nan Wang, Ben Zhang, Xinxiang Li
BACKGROUND & AIMS: Genome-wide association studies (GWASs) have associated approximately 50 loci with risk of colorectal cancer (C..
Stephanie L Schmit, Christopher K Edlund, Fredrick R Schumacher, Jian Gong, Tabitha A Harrison, Jeroen R Huyghe, Chenxu Qu, Marilena Melas, David J Van den Berg, Hansong Wang, Stephanie Tring, Sarah J Plummer, Demetrius Albanes, M Henar Alonso, Christopher I Amos, Kristen Anton, Aaron K Aragaki, Volker Arndt, Elizabeth L Barry, Sonja I Berndt
2019-02-01
BACKGROUND: Previous genome-wide association studies (GWAS) have identified 42 loci (P < 5 × 10-8) associated with risk of colorec..
Xia Jiang, Hilary K Finucane, Fredrick R Schumacher, Stephanie L Schmit, Jonathan P Tyrer, Younghun Han, Kyriaki Michailidou, Corina Lesseur, Karoline B Kuchenbaecker, Joe Dennis, David V Conti, Graham Casey, Mia M Gaudet, Jeroen R Huyghe, Demetrius Albanes, Melinda C Aldrich, Angeline S Andrew, Irene L Andrulis, Hoda Anton-Culver, Antonis C Antoniou
2019-01-25
Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Us..
Jeroen R Huyghe, Stephanie A Bien, Tabitha A Harrison, Hyun Min Kang, Sai Chen, Stephanie L Schmit, David V Conti, Conghui Qu, Jihyoun Jeon, Christopher K Edlund, Peyton Greenside, Michael Wainberg, Fredrick R Schumacher, Joshua D Smith, David M Levine, Sarah C Nelson, Nasa A Sinnott-Armstrong, Demetrius Albanes, M Henar Alonso, Kristin Anderson
2019-01-01
To further dissect the genetic architecture of colorectal cancer (CRC), we performed whole-genome sequencing of 1,439 cases and 72..
James Y Dai, Ulrike Peters, Xiaoyu Wang, Jonathan Kocarnik, Jenny Chang-Claude, Martha L Slattery, Andrew Chan, Mathieu Lemire, Sonja I Berndt, Graham Casey, Mingyang Song, Mark A Jenkins, Hermann Brenner, Aaron P Thrift, Emily White, Li Hsu
2018-12-01
Diagnosing pleiotropy is critical for assessing the validity of Mendelian randomization (MR) analyses. The popular MR-Egger method..
S Ghazaleh Dashti, Aung Ko Win, Sheetal S Hardikar, Stephen E Glombicki, Sheila Mallenahalli, Selvi Thirumurthi, Susan K Peterson, Y Nancy You, Daniel D Buchanan, Jane C Figueiredo, Peter T Campbell, Steven Gallinger, Polly A Newcomb, John D Potter, Noralane M Lindor, Loic Le Marchand, Robert W Haile, John L Hopper, Mark A Jenkins, Karen M Basen-Engquist
2018-11-01
Greater physical activity is associated with a decrease in risk of colorectal cancer for the general population; however, little i..
Sanne W ten Broeke, Heleen M van der Klift, Carli MJ Tops, Stefan Aretz, Inge Bernstein, Daniel D Buchanan, Albert de la Chapelle, Gabriel Capella, Mark Clendenning, Christoph Engel, Steven Gallinger, Encarna Gomez Garcia, Jane C Figueiredo, Robert Haile, Heather L Hampel, John L Hopper, Nicoline Hoogerbrugge, Magnus von Knebel Doeberitz, Loic Le Marchand, Tom GW Letteboer
2018-10-10
PURPOSE: Lynch syndrome due to pathogenic variants in the DNA mismatch repair genes MLH1, MSH2, and MSH6 is predominantly associat..
Dayna R Cenin, Steffie K Naber, Iris Lansdorp-Vogelaar, Mark A Jenkins, Daniel D Buchanan, David B Preen, Hooi C Ee, Peter O'Leary
2018-10-01
Background and Aim Individuals with Lynch syndrome (LS) are at increased risk of LS-related cancers including colorectal cancer (C..
Anaita Kanga-Parabia, Clara Gaff, Louisa Flander, Mark Jenkins, Louise A Keogh
Unaffected relatives of individuals with Lynch syndrome can be offered predictive genetic testing to guide surveillance recommenda..
Rish K Pai, Beth Dudley, Eve Karloski, Randall E Brand, Neil O'Callaghan, Christophe Rosty, Daniel D Buchanan, Mark A Jenkins, Stephen N Thibodeau, Amy J French, Noralane M Lindor, Reetesh K Pai
Lynch syndrome is the most common form of hereditary colorectal carcinoma. However, establishing the diagnosis of Lynch syndrome i..
Mary Dillon, Louisa Flander, Daniel D Buchanan, Finlay A Macrae, Jon D Emery, Ingrid M Winship, Alex Boussioutas, Graham G Giles, John L Hopper, Mark A Jenkins, Driss Ait Ouakrim
2018-08-01
BACKGROUND: The Australian National Bowel Cancer Screening Programme (NBCSP) was introduced in 2006. When fully implemented, the p..
Daniel D Buchanan, Jenna R Stewart, Mark Clendenning, Christophe Rosty, Khalid Mahmood, Bernard J Pope, Mark A Jenkins, John L Hopper, Melissa C Southey, Finlay A Macrae, Ingrid M Winship, Aung Ko Win
BACKGROUND: Germ-line mutations in the exonuclease domains of the POLE and POLD1 genes are associated with an increased, but yet u..
Sonja Neumeyer, Barbara L Banbury, Volker Arndt, Sonja I Berndt, Stephane Bezieau, Stephanie A Bien, Dan D Buchanan, Katja Butterbach, Bette J Caan, Peter T Campbell, Graham Casey, Andrew T Chan, Stephen J Chanock, James Y Dai, Steven Gallinger, Edward L Giovannucci, Graham G Giles, William M Grady, Jochen Hampe, Michael Hoffmeister
2018-06-01
BACKGROUND: Substantial evidence supports an association between use of menopausal hormone therapy and decreased colorectal cancer..
Yu-Ru Su, Chongzhi Di, Stephanie Bien, Licai Huang, Xinyuan Dong, Goncalo Abecasis, Sonja Berndt, Stephane Bezieau, Hermann Brenner, Bette Caan, Graham Casey, Jenny Chang-Claude, Stephen Chanock, Sai Chen, Charles Connolly, Keith Curtis, Jane Figueiredo, Manish Gala, Steven Gallinger, Tabitha Harrison
2018-05-03
Genome-wide association studies (GWASs) have successfully identified thousands of genetic variants for many complex diseases; howe..
Tomas Tanskanen, Linda van den Berg, Niko Valimaki, Mervi Aavikko, Eivind Ness-Jensen, Kristian Hveem, Yvonne Wettergren, Elinor Bexe Lindskog, Neeme Tonisson, Andres Metspalu, Kaisa Silander, Giulia Orlando, Philip J Law, Sari Tuupanen, Alexandra E Gylfe, Ulrika A Hanninen, Tatiana Cajuso, Johanna Kondelin, Antti-Pekka Sarin, Eero Pukkala
2018-02-01
Genome-wide association studies have been successful in elucidating the genetic basis of colorectal cancer (CRC), but there remain..
Lochlan J Fennell, Mark Clendenning, Diane M McKeone, Saara H Jamieson, Samanthy Balachandran, Jennifer Borowsky, John Liu, Futoshi Kawamata, Catherine E Bond, Christophe Rosty, Matthew E Burge, Daniel D Buchanan, Barbara A Leggett, Vicki LJ Whitehall
2018-01-01
The WNT signaling pathway is commonly altered during colorectal cancer development. The E3 ubiquitin ligase, RNF43, negatively reg..
Mark Clendenning, Alvin Huang, Harindra Jayasekara, Marie Lorans, Susan Preston, Neil O'Callaghan, Bernard J Pope, Finlay A Macrae, Ingrid M Winship, Roger L Milne, Graham G Giles, Dallas R English, John L Hopper, Aung K Win, Mark A Jenkins, Melissa C Southey, Christophe Rosty, Daniel D Buchanan
In colorectal cancers (CRCs) with tumour mismatch repair (MMR) deficiency, genes involved in the host immune response that contain..
Leon Raskin, Yan Guo, Liping Du, Mark Clendenning, Christophe Rosty, Noralane M Lindor, Stephen B Gruber, Daniel D Buchanan
2017-11-07
The underlying genetic cause of colorectal cancer (CRC) can be identified for 5-10% of all cases, while at least 20% of CRC cases ..
Henry Rodriguez-Broadbent, Philip J Law, Amit Sud, Kimmo Palin, Sari Tuupanen, Alexandra Gylfe, Ulrika A Hanninen, Tatiana Cajuso, Tomas Tanskanen, Johanna Kondelin, Eevi Kaasinen, Antti-Pekka Sarin, Samuli Ripatti, Johan G Eriksson, Harri Rissanen, Paul Knekt, Eero Pukkala, Pekka Jousilahti, Veikko Salomaa, Aarno Palotie
2017-06-15
While elevated blood cholesterol has been associated with an increased risk of colorectal cancer (CRC) in observational studies, c..