THE BRAIN AS A THERAPEUTIC TARGET FOR HEART FAILURE

Grant number: 1128108 | Funding period: 2017 - 2022

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Abstract

In heart failure there is a large increase in sympathetic nerve activity to the heart that leads to damage to the heart and sudden death. We have shown that lesion of the area postrema, a brain nucleus that senses hormones in the blood, reduces nerve activity to the heart and, importantly, improves cardiac function. We aim to translate these findings into a treatment that can be used clinically, which our findings compellingly indicate should improve cardiac function in heart failure

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