MECHANISMS AND TARGETS OF ANTIBODY-COMPLEMENT INTERACTIONS THAT NEUTRALIZE MALARIA

Grant number: 1141278 | Funding period: 2018 - 2020

Completed

Abstract

Our project aims to identify immune mechanisms that neutralize malaria from the moment of inoculation by a mosquito, before infection can become established to prevent the development of malaria disease. Furthermore, we will discover specific targets of protective immune responses. We expect this project will provide major new advances in our knowledge of human immunity to P. falciparum malaria, one of the world’s most significant causes of mortality and morbidity, and we will use this knowledge

Related publications (5)

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Age-dependent changes in circulating Tfh cells influence development of functional malaria antibodies in children

Jo-Anne Chan, Jessica R Loughland, Lauren de la Parte, Satomi Okano, Isaac Ssewanyana, Mayimuna Nalubega, Felistas Nankya, Kenneth Musinguzi, John Rek, Emmanuel Arinaitwe, Peta Tipping, Peter Bourke, Dean Andrew, Nicholas Dooley, Arya SheelaNair, Bruce D Wines, P Mark Hogarth, James G Beeson, Bryan Greenhouse, Grant Dorsey

2022-07-18

T-follicular helper (Tfh) cells are key drivers of antibodies that protect from malaria. However, little is known regarding the ho..

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Antibody Targets and Properties for Complement-Fixation Against the Circumsporozoite Protein in Malaria Immunity

Liriye Kurtovic, Damien R Drew, Arlene E Dent, James W Kazura, James G Beeson

2021-12-01

The Plasmodium falciparum circumsporozoite protein (CSP) forms the basis of leading subunit malaria vaccine candidates. However, t..

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Th2-like T Follicular Helper Cells Promote Functional Antibody Production during Plasmodium falciparum Infection

Jo-Anne Chan, Jessica R Loughland, Fabian de Labastida Rivera, Arya SheelaNair, Dean W Andrew, Nicholas L Dooley, Bruce D Wines, Fiona H Amante, Lachlan Webb, P Mark Hogarth, James S McCarthy, James G Beeson, Christian R Engwerda, Michelle J Boyle

2020-12-22

CD4+ T follicular helper cells (Tfh) are key drivers of antibody development. During Plasmodium falciparum malaria in children, th..

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Infection-induced plasmablasts are a nutrient sink that impairs humoral immunity to malaria

Rahul Vijay, Jenna J Guthmiller, Alexandria J Sturtz, Fionna A Surette, Kai J Rogers, Ramakrishna R Sompallae, Fengyin Li, Rosemary L Pope, Jo-Anne Chan, Fabian de Labastida Rivera, Dean Andrew, Lachlan Webb, Wendy J Maury, Hai-Hui Xue, Christian R Engwerda, James S McCarthy, Michelle J Boyle, Noah S Butler

2020-05-18

Plasmodium parasite–specific antibodies are critical for protection against malaria, yet the development of long-lived and effecti..

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Loss of complement regulatory proteins on uninfected erythrocytes in vivax and falciparum malaria anemia

Damian A Oyong, Enny Kenangalem, Jeanne R Poespoprodjo, James G Beeson, Nicholas M Anstey, Ric N Price, Michelle J Boyle

2018-11-15

Anemia is a major complication of malaria, driven largely by loss of uninfected RBCs during infection. RBC clearance through loss ..

University of Melbourne Researchers