TARGETING DYSFUNCTIONAL MITOCHONDRIA IN MACROPHAGES TO INHIBIT ATHEROSCLEROSIS
Grant number: 1142938 | Funding period: 2018 - 2021
The major contributing cells to heart disease are macrophages. These cells scavenge cholesterol, keeping the blood vessels clean and limiting heart disease. The macrophages must process and donate the scavenged cholesterol onto HDL-cholesterol that carries them back to the liver for removal. This process requires the powerhouse of the cell, the mitochondria to be functional. We have discovered that process fails and have novel drugs to re-instate this process of cholesterol removal.