Novel chemoenzymatic synthesis and bioconjugation of peptides and proteins

Grant number: LP170101085 | Funding period: 2019 - 2023

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Abstract

This project aims to solve the critical difficulty of producing the complex peptide insulin and related insulin-like peptides (INSLs) and their analogues. The project will use unique, recyclable enzymes which ligate smaller peptide segments with extraordinary site and substrate selectivity. The expected outcome of the project is novel, cheaper and scalable, enzyme-mediated engineering of this critical class of peptides as biological probes and potential therapeutic agents.