NEW DIAGNOSTICS TO PREDICT PREECLAMPSIA AND FETAL GROWTH RESTRICTION

Circulating Growth Differentiation Factor 15 Is Increased Preceding Preeclampsia Diagnosis: Implications as a Disease Biomarker

Tess Cruickshank, Teresa M MacDonald, Susan P Walker, Emerson Keenan, Kirsten Dane, Anna Middleton, Valerie Kyritsis, Jenny Myers, Catherine Cluver, Roxanne Hastie, Lina Bergman, Damanpreet Garcha, Ping Cannon, Elizabeth Murray, Tuong-Vi Nguyen, Richard Hiscock, Natasha Pritchard, Natalie J Hannan, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino

2021-08-17

Background We investigated the biomarker potential of growth differentiation factor 15 (GDF-15), a stress response protein highly ..

Circulating syndecan-1 is reduced in pregnancies with poor fetal growth and its secretion regulated by matrix metalloproteinases and the mitochondria

Damanpreet Garcha, Susan P Walker, Teresa M MacDonald, Jon Hyett, Jessica Jellins, Jenny Myers, Sebastian E Illanes, Jhy K Nien, Manuel Schepeler, Emerson Keenan, Carole-Anne Whigham, Ping Cannon, Elizabeth Murray, Tuong-Vi Nguyen, Manju Kandel, Joshua Masci, Ciara Murphy, Tess Cruickshank, Natasha Pritchard, Natalie J Hannan

2021-08-16

Fetal growth restriction is a leading cause of stillbirth that often remains undetected during pregnancy. Identifying novel biomar..

LOX-1 expression is reduced in placenta from pregnancies complicated by preeclampsia and in hypoxic cytotrophoblast

Natasha de Alwis, Sally Beard, Natalie K Binder, Natasha Pritchard, Tu'uhevaha J Kaitu'u-Lino, Susan P Walker, Owen Stock, Katie M Groom, Scott Petersen, Amanda Henry, Joanne M Said, Sean Seeho, Stefan C Kane, Stephen Tong, Natalie J Hannan

2021-08-01

OBJECTIVES: The lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is upregulated in the maternal vasculature in pree..

Pre-Clinical Investigation of Cardioprotective Beta-Blockers as a Therapeutic Strategy for Preeclampsia

Natalie K Binder, Teresa M MacDonald, Sally A Beard, Natasha de Alwis, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino, Natalie J Hannan

2021-08-01

Despite significant maternal and fetal morbidity, a treatment for preeclampsia currently remains an unmet need in clinical care. A..

DAAM2 is elevated in the circulation and placenta in pregnancies complicated by fetal growth restriction and is regulated by hypoxia

Natasha de Alwis, Sally Beard, Natalie K Binder, Natasha Pritchard, Tu'uhevaha J Kaitu'u-Lino, Susan P Walker, Owen Stock, Katie Groom, Scott Petersen, Amanda Henry, Joanne M Said, Sean Seeho, Stefan C Kane, Lisa Hui, Stephen Tong, Natalie J Hannan

2021-03-10

Previously, we identified increased maternal circulating DAAM2 mRNA in pregnancies complicated by preterm fetal growth restriction..

Nanoparticles in pregnancy: the next frontier in reproductive therapeutics

Natasha Pritchard, Tu'uhevaha Kaitu'u-Lino, Lynda Harris, Stephen Tong, Natalie Hannan

2021-03-01

BACKGROUND: Nanotechnology involves the engineering of structures on a molecular level. Nanomedicine and nano-delivery systems hav..

Circulating Tissue Factor Pathway Inhibitor (TFPI) is increased preceding preeclampsia diagnosis and in established preeclampsia

Teresa M MacDonald, Stephen Tong, Jenny Myers, Ping Cannon, Nguyen Tuong-Vi, Emerson Keenan, Elizabeth Murray, Alesia Harper, Natasha Pritchard, Natalie J Hannan, Kirsten M Dane, Anna L Middleton, Valerie P Kyritsis, Susan P Walker, Tu'uhevaha J Kaitu'u-Lino

2021-02-01

INTRODUCTION: Tissue Factor Pathway Inhibitor (TFPI) is a part of the extrinsic coagulation pathway, and highly expressed in the p..

Pravastatin, proton-pump inhibitors, metformin, micronutrients, and biologics: new horizons for the prevention or treatment of preeclampsia.

Stephen Tong, Tu'uhevaha J Kaitu'u-Lino, Roxanne Hastie, Fiona Brownfoot, Catherine Cluver, Natalie Hannan

2020-09-16

There has been increasing research momentum to identify new therapeutic agents for the prevention or treatment of preeclampsia, dr..

Aurora kinase mRNA expression is reduced with increasing gestational age and in severe early onset fetal growth restriction

Sally Beard, Natasha Pritchard, Natalie Binder, Karen Schindler, Natasha De Alwis, Tu'uhevaha J Kaitu'u-Lino, Stephen Tong, Natalie J Hannan

2020-06-01

INTRODUCTION: Oxidative damage and biochemical ageing are implicated in placental dysfunction and potentially fetal death. Cellula..

Combining metformin and sulfasalazine additively reduces the secretion of antiangiogenic factors from the placenta: Implications for the treatment of preeclampsia

Fiona C Brownfoot, Roxanne Hastie, Natalie J Hannan, Ping Cannon, Tuong Nguyen, Laura Tuohey, Cathy Cluver, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino

2020-06-01

INTRODUCTION: The antiangiogenic factors soluble fms-like tyrosine kinase-1 (sFlt-1) and soluble endoglin (sENG) are elevated in p..

Circulating mRNAs are differentially expressed in pregnancies with severe placental insufficiency and at high risk of stillbirth

Natalie J Hannan, Owen Stock, Rebecca Spencer, Clare Whitehead, Anna L David, Katie Groom, Scott Petersen, Amanda Henry, Joanne M Said, Sean Seeho, Stefan C Kane, Lavinia Gordon, Sally Beard, Kantaraja Chindera, Smita Karegodar, Richard Hiscock, Natasha Pritchard, Tu'uhevaha J Kaitu'u-Lino, Susan P Walker, Stephen Tong

2020-05-22

Background Fetuses affected by placental insufficiency do not receive adequate nutrients and oxygenation, become growth restricted..

Circulating SPINT1 is a biomarker of pregnancies with poor placental function and fetal growth restriction

Tu'uhevaha J Kaitu'u-Lino, Teresa M MacDonald, Ping Cannon, Nguyen Tuong-Vi, Richard J Hiscock, Nick Haan, Jenny E Myers, Roxanne Hastie, Kirsten M Dane, Anna L Middleton, Intissar Bittar, Amanda N Sferruzzi-Perri, Natasha Pritchard, Alesia Harper, Natalie J Hannan, Valerie Kyritsis, Nick Crinis, Lisa Hui, Susan P Walker, Stephen Tong

2020-05-15

Purpose To investigate the relationship between patient-reported outcome (PRO) questionnaire responses and time to late age-relate..

Pravastatin as the statin of choice for reducing pre-eclampsia-associated endothelial dysfunction

Natasha de Alwis, Sally Beard, Yeukai T Mangwiro, Natalie K Binder, Tu'uhevaha J Kaitu'u-Lino, Fiona C Brownfoot, Stephen Tong, Natalie J Hannan

2020-04-01

OBJECTIVES: There is avid interest in pravastatin as a therapeutic intervention for pre-eclampsia, however little is known on stat..

Death associated protein kinase 1 (DAPK-1) is increased in preeclampsia

Cameron Yung, Teresa M MacDonald, Susan P Walker, Ping Cannon, Alesia Harper, Natasha Pritchard, Natalie J Hannan, Tu'uhevaha J Kaitu'u-Lino, Stephen Tong

2019-12-01

INTRODUCTION: Death associated protein kinase-1 (DAPK-1) is highly expressed in the placenta relative to all other human tissues. ..

Screening circulating proteins to identify biomarkers of fetal macrosomia.

Tess Cruickshank, Tu'uhevaha J Kaitu'u-Lino, Ping Cannon, Alesia Harper, Tuong-Vi Nguyen, Kirsten M Dane, Anna L Middleton, Valerie P Kyritsis, Roxanne Hastie, Stephen Tong, Susan P Walker, Teresa M MacDonald

2019-09-18

OBJECTIVE: Fetal macrosomia is a major risk factor for shoulder dystocia, which can lead to birth asphyxia, maternal and neonatal ..

The untapped potential of placenta-enriched molecules for diagnostic and therapeutic development

Carole-Anne Whigham, Teresa M MacDonald, Susan P Walker, Natalie J Hannan, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino

2019-09-01

Pregnancy complications such as fetal growth restriction and preeclampsia are diseases with limited biomarkers for prediction, and..