CHARACTERISATION AND DEVELOPMENT OF MAIT CELLS

Grant number: 1160333 | Funding period: 2019 - 2022

Completed

Abstract

MAIT cells are the most abundant T cell population in the human immune system, and have striking clinical potential for universal immunotherapy. Curiously however, MAIT cell numbers vary widely between individuals, so I seek to understand how they develop and decipher factors that control their function and numbers. This work will set the scene for future studies, and yield important clues about how best to target MAIT cells so they can be exploited as immunotherapy for diseases like cancer.

Related publications (10)

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Are NKT cells a useful predictor of COVID-19 severity?

Hui-Fern Koay, Nicholas A Gherardin, Thi HO Nguyen, Wuji Zhang, Jennifer R Habel, Rebecca Seneviratna, Fiona James, Natasha E Holmes, Olivia C Smibert, Claire L Gordon, Jason A Trubiano, Katherine Kedzierska, Dale I Godfrey

2022-02-08

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MAIT cells regulate NK cell-mediated tumor immunity

Emma Petley, Hui-Fern Koay, Melissa A Henderson, Kevin Sek, Kirsten L Todd, Simon P Keam, Junyun Lai, Imran G House, Jasmine Li, Magnus Zethoven, Amanda XY Chen, Amanda J Oliver, Jessica Michie, Andrew J Freeman, Lauren Giuffrida, Jack D Chan, Angela Pizzolla, Jeffrey YW Mak, Timothy R McCulloch, Fernando Souza-Fonseca-Guimaraes

2021-08-06

The function of MR1-restricted mucosal-associated invariant T (MAIT) cells in tumor immunity is unclear. Here we show that MAIT ce..

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An unconventional view of COVID-19 T cell immunity

Hui-Fern Koay, Thomas S Fulford, Dale I Godfrey

2020-12-01

In this issue of JEM, Jouan et al. (https://doi.org/10.1084/jem.20200872) report the activation and skewed function of unconventio..

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Thymic development of unconventional T cells: how NKT cells, MAIT cells and gamma delta T cells emerge

Daniel G Pellicci, Hui-Fern Koay, Stuart P Berzins

2020-06-24

T cell lineages are defined by specialized functions and differential expression of surface antigens, cytokines and transcription ..

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Human Mucosal-Associated Invariant T Cells in Older Individuals Display Expanded TCR alpha beta Clonotypes with Potent Antimicrobial Responses

Liyen Loh, Nicholas A Gherardin, Sneha Sant, Ludivine Grzelak, Jeremy Chase Crawford, Nicola L Bird, Hui-Fern Koay, Carolien E van de Sandt, Marcela L Moreira, Martha Lappas, E Kaitlynn Allen, Jane Crowe, Thomas Loudovaris, Katie L Flanagan, Kylie M Quinn, Jamie Rossjohn, Paul G Thomas, Sidonia BG Eckle, James McCluskey, Dale I Godfrey

2020-03-01

Mucosal-associated invariant T (MAIT) cells are important for immune responses against microbial infections. Although known to und..

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The biology and functional importance of MAIT cells

Dale Godfrey, Hui-Fern Koay, James McCluskey, Nicholas A Gherardin

2019-09-01

In recent years, a population of unconventional T cells called 'mucosal-associated invariant T cells' (MAIT cells) has captured th..

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TCF-1 limits the formation of Tc17 cells via repression of the MAF-ROR gamma t axis

Lisa A Mielke, Yang Liao, Ella Bridie Clemens, Matthew A Firth, Brigette Duckworth, Qiutong Huang, Francisca F Almeida, Michael Chopin, Hui-Fern Koay, Carolyn A Bell, Soroor Hediyeh-Zadeh, Simone L Park, Dinesh Raghu, Jarny Choi, Tracy L Putoczki, Philip D Hodgkin, Ashley E Franks, Laura K Mackay, Dale Godfrey, Melissa J Davis

2019-07-01

Interleukin (IL)-17-producing CD8+ T (Tc17) cells have emerged as key players in host-microbiota interactions, infection, and canc..

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Diverse MR1-restricted T cells in mice and humans.

Hui-Fern Koay, Nicholas A Gherardin, Calvin Xu, Rebecca Seneviratna, Zhe Zhao, Zhenjun Chen, David P Fairlie, James McCluskey, Daniel G Pellicci, Adam P Uldrich, Dale I Godfrey

2019-05-21

Mucosal-associated invariant T (MAIT) cells express an invariant TRAV1/TRAJ33 TCR-α chain and are restricted to the MHC-I-like mol..

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Divergent SATB1 expression across human life span and tissue compartments

Simone Nussing, Hui-Fern Koay, Sneha Sant, Thomas Loudovaris, Stuart I Mannering, Martha Lappas, Yves d'Udekem, Igor E Konstantinov, Stuart P Berzins, Guus F Rimmelzwaan, Stephen J Turner, E Bridie Clemens, Dale I Godfrey, HO Nguyen Thi, Katherine Kedzierska

2019-05-01

Special AT-rich binding protein-1 (SATB1) is a global chromatin organizer capable of activating or repressing gene transcription i..

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MicroRNA-managing the development of MAIT cells

Hui-Fern Koay, Dale I Godfrey

2019-02-01

University of Melbourne Researchers