TARGETING ACTIVINS TO TREAT CACHEXIA

Activin A-Induced Cachectic Wasting Is Attenuated by Systemic Delivery of Its Cognate Propeptide in Male Mice

Kelly L Walton, Justin L Chen, Quinn Arnold, Emily Kelly, Mylinh La, Louis Lu, George Lovrecz, Adam Hagg, Timothy D Colgan, Hongwei Qian, Paul Gregorevic, Craig A Harrison

2019-10-01

In cancer, elevated activin levels promote cachectic wasting of muscle, irrespective of tumor progression. In excess, activins A a..

Molecular characterization of latent GDF8 reveals mechanisms of activation

Ryan G Walker, Jason C McCoy, Magdalena Czepnik, Melanie J Mills, Adam Hagg, Kelly L Walton, Thomas R Cotton, Marko Hyvonen, Richard T Lee, Paul Gregorevic, Craig A Harrison, Thomas B Thompson

2018-01-30

Specific targeting of TGF-beta family ligands demonstrates distinct roles in the regulation of muscle mass in health and disease

Justin L Chen, Kelly L Walton, Adam Hagg, Timothy D Colgan, Katharine Johnson, Hongwei Qian, Paul Gregorevic, Craig A Harrison

2017-06-27