Defining the Epigenetic Origins of Maternally Inherited Disease.

Grant number: 1144966 | Funding period: 2018 - 2020

Completed

Abstract

Epigenetic (non genetic) changes to the DNA in sperm and eggs can alter outcomes in children. Despite the potential for drugs and diet to mediate some of these inherited effects, the processes involved are very poorly understood. By determining the mechanisms that regulate epigenetic inheritance, this project will improve our understanding of how epigenetic mechanisms acting in the parent, can mediate inherited disease and life-long health outcomes in our children.

Related publications (2)

Fetal growth delay caused by loss of non-canonical imprinting is resolved late in pregnancy and culminates in offspring overgrowth

R Oberin, S Petautschnig, EG Jarred, Z Qu, T Tsai, NA Youngson, G Pulsoni, TT Truong, D Fernando, H Bildsoe, RO Blücher, M van den Buuse, DK Gardner, NA Sims, DL Adelson, PS Western

2024-05-30

Germline epigenetic programming, including genomic imprinting, substantially influences offspring development. Polycomb Repressive..

Transient Polycomb activity represses developmental genes in growing oocytes

EG Jarred, Z Qu, T Tsai, R Oberin, S Petautschnig, H Bildsoe, S Pederson, QH Zhang, JM Stringer, J Carroll, DK Gardner, M Van den Buuse, NA Sims, WT Gibson, DL Adelson, PS Western

2022-12-01

Background: Non-genetic disease inheritance and offspring phenotype are substantially influenced by germline epigenetic programmin..

University of Melbourne Researchers

David Gardner