Determining the Impacts of Epigenetic Modifying Drugs on Germline Programming and Offspring Health

Grant number: 1144887 | Funding period: 2018 - 2020

Completed

Abstract

New drugs have been developed that inhibit specific enzymes that regulate epigenetic pathways in cells. These pathways significantly affect growth and development in offspring and may represent a risk to future children of patients taking the drug. This project will determine these risks and provide data for developing clinical guidelines for safe use of the drugs.

Related publications (1)

Fetal growth delay caused by loss of non-canonical imprinting is resolved late in pregnancy and culminates in offspring overgrowth

R Oberin, S Petautschnig, EG Jarred, Z Qu, T Tsai, NA Youngson, G Pulsoni, TT Truong, D Fernando, H Bildsoe, RO Blücher, M van den Buuse, DK Gardner, NA Sims, DL Adelson, PS Western

2024-05-30

Germline epigenetic programming, including genomic imprinting, substantially influences offspring development. Polycomb Repressive..

University of Melbourne Researchers

David Gardner