TARGETING THERAPEUTIC STIMULATION USING MINIMALLY INVASIVE NEUROMODULATION

In Vivo Impedance Characterization of Cortical Recording Electrodes Shows Dependence on Electrode Location and Size

Sam E John, Nicholas V Apollo, Nicholas L Opie, Gil S Rind, Stephen M Ronayne, Clive N May, Thomas J Oxley, David B Grayden

2019-03-01

OBJECTIVE: Neural prostheses are improving the quality of life for those suffering from neurological impairments. Electrocorticogr..

Focal stimulation of the sheep motor cortex with a chronically implanted minimally invasive electrode array mounted on an endovascular stent

Nicholas L Opie, Sam E John, Gil S Rind, Stephen M Ronayne, Yan T Wong, Giulia Gerboni, Peter E Yoo, Timothyj H Lovell, Theodore CM Scordas, Stefan L Wilson, Anthony Dornom, Thomas Vale, Terence J O'brien, David B Grayden, Clive N May, Thomasj Oxley

2018-12-01

Direct electrical stimulation of the brain can alleviate symptoms associated with Parkinson's disease, depression, epilepsy and ot..

Feasibility of identifying the ideal locations for motor intention decoding using unimodal and multimodal classification at 7T-fMRI

Peter E Yoo, Thomas J Oxley, Sam E John, Nicholas L Opie, Roger J Ordidge, Terence J O'Brien, Maureen A Hagan, Yan T Wong, Bradford A Moffat

2018-10-22

Invasive Brain-Computer Interfaces (BCIs) require surgeries with high health-risks. The risk-to-benefit ratio of the procedure cou..

Optimized partial-coverage functional analysis pipeline (OPFAP): a semi-automated pipeline for skull stripping and co-registration of partial-coverage, ultra-high-field functional images

Peter E Yoo, Jon O Cleary, Scott C Kolbe, Roger J Ordidge, Terence J O'Brien, Nicholas L Opie, Sam E John, Thomas J Oxley, Bradford A Moffat

2018-10-01

OBJECTIVE: Ultra-high-field functional MRI (UHF-fMRI) allows for higher spatiotemporal resolution imaging. However, higher-resolut..

Visual evoked potentials determine chronic signal quality in a stent-electrode endovascular neural interface

G Gerboni, SE John, GS Rind, SM Ronayne, CN May, TJ Oxley, DB Grayden, NL Opie, YT Wong

2018-09-01

Brain-machine interfaces directly communicate between the brain and external devices. An effective trade-off between signal qualit..

Cortical Brain Stimulation with Endovascular Electrodes.

G Gerboni, SE John, SM Ronayne, GS Rind, CN May, TJ Oxley, DB Grayden, NL Opie, YT Wong

2018-07-26

Electrical stimulation of neural tissue and recording of neural activity are the bases of emerging prostheses and treatments for s..

Effect of Implant Duration, Anatomical Location and Electrode Orientation on Bandwidth Recorded with a Chronically Implanted Endovascular Stent-Electrode Array

N Opie, S John, G Rind, S Ronayne, Clive May, David Grayden, Thomas Oxley

2018-07-26

Access to the brain to implant recording electrodes has conventionally required a craniotomy. To mitigate risks of open brain surg..

Spatially dynamic recurrent information flow across long-range dorsal motor network encodes selective motor goals

Peter E Yoo, Maureen A Hagan, Sam E John, Nicholas L Opie, Roger J Ordidge, Terence J O'Brien, Thomas J Oxley, Bradford A Moffat, Yan T Wong

2018-06-01

Performing voluntary movements involves many regions of the brain, but it is unknown how they work together to plan and execute sp..

Signal quality of simultaneously recorded endovascular, subdural and epidural signals are comparable

Sam E John, Nicholas L Opie, Yan T Wong, Gil S Rind, Stephen M Ronayne, Giulia Gerboni, Sebastien H Bauquier, Terence J O'Brien, Clive N May, David B Grayden, Thomas J Oxley

2018-05-30

Recent work has demonstrated the feasibility of minimally-invasive implantation of electrodes into a cortical blood vessel. Howeve..

An ovine model of cerebral catheter venography for implantation of an endovascular neural interface

Thomas James Oxley, Nicholas Lachlan Opie, Gil Simon Rind, Kishan Liyanage, Sam Emmanuel John, Stephen Ronayne, Alan James McDonald, Anthony Dornom, Timothy John Haynes Lovell, Peter John Mitchell, Iwan Bennett, Sebastien Bauquier, Leon Norris Warne, Chris Steward, David Bruce Grayden, Patricia Desmond, Stephen M Davis, Terence John O'Brien, Clive N May

2018-04-01

OBJECTIVE Neural interface technology may enable the development of novel therapies to treat neurological conditions, including mo..

Consistency of Long-Term Subdural Electrocorticography in Humans

Ewan S Nurse, Sam E John, Dean R Freestone, Thomas J Oxley, Hoameng Ung, Samuel F Berkovic, Terence J O'Brien, Mark J Cook, David B Grayden

2018-02-01

OBJECTIVE: Subdural electrocorticography (ECoG) can provide a robust control signal for a brain-computer interface (BCI). However,..

7T-fMRI: Faster temporal resolution yields optimal BOLD sensitivity for functional network imaging specifically at high spatial resolution

Peter E Yoo, Sam E John, Shawna Farquharson, Jon O Cleary, Yan T Wong, Amanda Ng, Claire B Mulcahy, David B Grayden, Roger J Ordidge, Nicholas L Opie, Terence J O'Brien, Thomas J Oxley, Bradford A Moffat

2018-01-01

Recent developments in accelerated imaging methods allow faster acquisition of high spatial resolution images. This could improve ..

The ovine motor cortex: A review of functional mapping and cytoarchitecture

Sam E John, Timothy JH Lovell, Nicholas L Opie, Stefan Wilson, Theodore C Scordas, Yan T Wong, Gil S Rind, Stephen Ronayne, Sebastien H Bauquier, Clive N May, David B Grayden, Terence J O'Brien, Thomas J Oxley

2017-09-01

In recent years, sheep (Ovis aries) have emerged as a useful animal model for neurological research due to their relatively large ..

Micro-CT and Histological Evaluation of an Neural Interface Implanted Within a Blood Vessel

Nicholas Lachlan Opie, Nicole R van der Nagel, Sam E John, Kirstan Vessey, Gil S Rind, Stephen M Ronayne, Erica L Fletcher, Clive N May, Terence J O'Brien, Thomas J Oxley

2017-04-01

OBJECTIVE: Recently, we reported the development of a stent-mounted electrode array (Stentrode) capable of chronically recording n..

A Minimally Invasive Endovascular Stent-Electrode Array for Chronic Recordings of Cortical Neural Activity

Thomas J Oxley, Nicholas L Opie, Sam E John, Gil S Rind, Stephen M Ronayne, Anthony N Burkitt, David B Grayden, Clive N May, Terence J O'Brien

2017-01-01

Intracranial electrode arrays for recording and stimulating electrical brain activity have facilitated major advances in the treat..

Chronic impedance spectroscopy of an endovascular stent-electrode array

Nicholas L Opie, Sam E John, Gil S Rind, Stephen M Ronayne, David B Grayden, Anthony N Burkitt, Clive N May, Terence J O'Brien, Thomas J Oxley

2016-08-01

OBJECTIVE: Recently, we reported a minimally invasive stent-electrode array capable of recording neural signals from within a bloo..

The evolution of endovascular electroencephalography: historical perspective and future applications

Roberta K Sefcik, Nicholas L Opie, Sam E John, Christopher P Kellner, J Mocco, Thomas J Oxley

2016-05-01

Current standard practice requires an invasive approach to the recording of electroencephalography (EEG) for epilepsy surgery, dee..

Feasibility of a Chronic, Minimally Invasive Endovascular Neural Interface

Nicholas L Opie, Gil S Rind, Sam E John, Stephen M Ronayne, David B Grayden, Anthony N Burkitt, Clive N May, Terence J O'Brien, Thomas J Oxley

2016-01-01

Development of a neural interface that can be implanted without risky, open brain surgery will increase the safety and viability o..

Suitability of Nitinol Electrodes in Neural Prostheses such as Endovascular Neural Interfaces

Yan T Wong, Nicholas L Opie, Sam E John, Giulia Gerboni, Gil S Rind, Stephen M Ronayne, Kate E Fox, Thomas J Oxley, David B Grayden

2016-01-01

A major challenge facing neural prostheses is the development of electrodes that are well tolerated by the brain and body. A novel..