THE ARTHROPLASTY SURGICAL ANTIBIOTIC PROPHYLAXI (ASAP) STUDY

Grant number: 1120331 | Funding period: 2017 - 2021

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Abstract

The demand for total joint replacement surgery will double over the next decade. Infection involving the surgical wound is a devastating complication of this surgery. Half of all infections are due to methicillin resistant Staphylococcus (such as MRSA) and Enterococcus. This multicentre randomised controlled trial aims to investigate whether the addition of vancomycin at the time of surgery reduces the incidence of surgical wound infections; is safe and is cost-effective.

Related publications (1)

Multicentre randomised double-blind placebo controlled trial of combination vancomycin and cefazolin surgical antibiotic prophylaxis: the Australian surgical antibiotic prophylaxis (ASAP) trial

Trisha Peel, Sarah Astbury, Allen C Cheng, David Paterson, Kirsty Buising, Tim Spelman, Tran-Duy An, Richard S de Steiger, Peter Choong, Allen Cheng, David Paterson, Kirsty Buising, Michelle Dowsey, Ross Crawford, Tim Spelman, Philip Clarke, Ben Howden, Peter Rehfisch, Robert Molnar, Sam Adie

2019-11-01

INTRODUCTION: Resistant Gram-positive organisms, such as methicillin-resistant staphylococci, account for a significant proportion..