RANDOMISED PHASE III TRIAL OF ADJUVANT RADIOTHERAPY VERSUS OBSERVATION FOLLOWING BREAST CONSERVING SURGERY AND ENDOCRINE THERAPY IN PATIENTS WITH MOLECULARLY CHARACTERISED LOW-RISK LUMINAL A EARLY BREAST CANCER

Grant number: 1099899 | Funding period: 2016 - 2021

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Abstract

Radiotherapy after surgery for early breast cancer decreases recurrence but its benefit varies. Thus, it is important to identify low-risk patients who are unlikely to benefit from radiotherapy, sparing them its toxicity and costs. We propose a randomised study to investigate if patients whose breast cancer is postulated to be low-risk based on PAM50 (a 50-gene test) may safely omit radiotherapy after surgery. If successful, these patients will be able to avoid the risks of over-treatment.

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