RANDOMISED PHASE III TRIAL OF ADJUVANT RADIOTHERAPY VERSUS OBSERVATION FOLLOWING BREAST CONSERVING SURGERY AND ENDOCRINE THERAPY IN PATIENTS WITH MOLECULARLY CHARACTERISED LOW-RISK LUMINAL A EARLY BREAST CANCER
Grant number: 1099899 | Funding period: 2016 - 2021
Radiotherapy after surgery for early breast cancer decreases recurrence but its benefit varies. Thus, it is important to identify low-risk patients who are unlikely to benefit from radiotherapy, sparing them its toxicity and costs. We propose a randomised study to investigate if patients whose breast cancer is postulated to be low-risk based on PAM50 (a 50-gene test) may safely omit radiotherapy after surgery. If successful, these patients will be able to avoid the risks of over-treatment.
Related publications (21)
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Michael Jefford, Andrew C Ward, Karolina Lisy, Karen Lacey, Jon D Emery, Adam W Glaser, Hannah Cross, Mei Krishnasamy, Sue-Anne McLachlan, Jim Bishop
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T Shaw, P Yates, B Moore, K Ash, L Nolte, M Krishnasamy, J Nicholson, M Rynderman, J Avery, M Jefford
Cancer survivorship is recognised globally as a key issue. In spite of the key role played by nurses in survivorship care, there i..
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Leanne Monterosso, Karen Taylor, Violet Platt, Elizabeth Lobb, Meinir Krishnasamy, Toni Musiello, Caroline Bulsara, Kendall Stratton, David Joske
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Self-guided interventions for managing psychological distress in people with cancer - A systematic review
Anna Ugalde, Kerry Haynes, Anna Boltong, Victoria White, Meinir Krishnasamy, Penelope Schofield, Sanchia Aranda, Patricia Livingston
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Individualised mindfulness-based stress reduction for head and neck cancer patients undergoing radiotherapy of curative intent: a descriptive pilot study
A Pollard, JL Burchell, D Castle, K Neilson, M Ftanou, J Corry, D Rischin, DW Kissane, M Krishnasamy, LE Carlson, J Couper
People with head and neck cancer (HNC) experience elevated symptom toxicity and co-morbidity as a result of treatment, which is as..
The Women's wellness after cancer program: a multisite, single-blinded, randomised controlled trial protocol
Debra Anderson, Charrlotte Seib, Dian Tjondronegoro, Jane Turner, Leanne Monterosso, Amanda McGuire, Janine Porter-Steele, Wei Song, Patsy Yates, Neil King, Leonie Young, Kate White, Kathryn Lee, Sonj Hall, Mei Krishnasamy, Kathy Wells, Sarah Balaam, Alexandra L McCarthy
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The Cancer Nurse Coordinator Service in Western Australia: perspectives of specialist cancer nurse coordinators
Leanne Monterosso, Patsy Yates, Violet Platt, Caroline Bulsara, Meinir Krishnasamy
Objective In Western Australia the cancer nurse coordinator (CNC) role is unique, state wide and situated in nursing. It requires ..
A Randomized Controlled Trial of a Nurse-Led Supportive Care Package (SurvivorCare) for Survivors of Colorectal Cancer
Michael Jefford, Karla Gough, Aallison Drosdowsky, Lahiru Russell, Sanchia Aranda, Phyllis Butow, Jo Phipps-Nelson, Jane Young, Mei Krishnasamy, Anna Ugalde, Dorothy King, Andrew Strickland, Michael Franco, Robert Blum, Catherine Johnson, Vinod Ganju, Jeremy Shapiro, Geoffrey Chong, Julie Charlton, Andrew Haydon
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Developing and evaluating Robocare; an innovative, nurse-led robotic prostatectomy care pathway
Emma Birch, Siska van Bruwaene, Wouter Everaerts, Kathryn Schubach, Matiu Bush, Mei Krishnasamy, Daniel A Moon, Jeremy Goad, Nathan Lawrentschuk, Declan G Murphy
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Developing an Evidence-Based, Nurse-Led Psychoeducational Intervention With Peer Support in Gynecologic Oncology
Rebecca J Bergin, Suzi M Grogan, David Bernshaw, Ilona Juraskova, Sylvia Penberthy, Linda R Mileshkin, Meinir Krishnasamy, Alison C Hocking, Sanchia K Aranda, Penelope E Schofield
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Early and Intensive Dietary Counseling in Lung Cancer Patients Receiving (Chemo)Radiotherapy-A Pilot Randomized Controlled Trial
Nicole Kiss, Elisabeth Isenring, Karla Gough, Greg Wheeler, Andrew Wirth, Belinda A Campbell, Meinir Krishnasamy
Malnutrition is prevalent in patients undergoing (chemo)radiotherapy (RT) for lung cancer. This pilot study tested the feasibility..
Psychological distress, quality of life, symptoms and unmet needs of colorectal cancer survivors near the end of treatment
Lahiru Russell, Karla Gough, Allison Drosdowsky, Penelope Schofield, Sanchia Aranda, Phyllis N Butow, Jennifer A Westwood, Mei Krishnasamy, Jane M Young, Jo Phipps-Nelson, Dorothy King, Michael Jefford
PURPOSE: This study investigated psychological morbidity, quality of life (QoL), colorectal cancer (CRC)-specific symptoms and sup..
A mixed method feasibility study of a patient- and family-centred advance care planning intervention for cancer patients
N Michael, C O'Callaghan, A Baird, K Gough, M Krishnasamy, N Hiscock, J Clayton
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Cancer care coordination: building a platform for the development of care coordinator roles and ongoing evaluation
Louise Freijser, Lucio Naccarella, Rosemary McKenzie, Meinir Krishnasamy
Continuity of care is integral to the quality and safety of care provided to people with cancer and their carers. Further evidence..
Supportive Care in Lung Cancer Milestones Over the Past 40 Years
Alex Molassiotis, Wilma Uyterlinde, Patricia J Hollen, Linda Sarna, Patricia Palmer, Meinir Krishnasamy
The evolution of supportive care in lung cancer (LC) is the focus of this article, which aims to present an overall picture of the..
Dosimetric factors associated with weight loss during (chemo)radiotherapy treatment for lung cancer
N Kiss, M Krishnasamy, S Everitt, K Gough, M Duffy, E Isenring
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The prevalence of weight loss during (chemo)radiotherapy treatment for lung cancer and associated patient- and treatment-related factors
Nicole Kiss, Elisabeth Isenring, Karla Gough, Meinir Krishnasamy
BACKGROUND & AIMS: Thoracic radiotherapy is associated with toxicities that can adversely impact nutritional intake. This study ai..
The Relationship between Self-Efficacy and Anxiety and General Distress in Caregivers of People with Advanced Cancer
Anna Ugalde, Meinir Krishnasamy, Penelope Schofield
BACKGROUND: Informal caregivers take on an important role in supporting people with advanced cancer but experience significant psy..