CRITICAL REGULATORS OF PLACENTATION
Grant number: 1098332 | Funding period: 2018 - 2020
The placenta is essential for fetal-maternal exchange and healthy pregnancy however the factors that are required for the placenta to form are poorly understood. We will investigate how the placenta develops in mice and which are the most important factors that are required for a health placenta to form.
Related publications (6)
Prednisolone Alters Endometrial Decidual Cells and Affects Decidual-Trophoblast Interactions
Eliza Grbac, Teresa So, Swati Varshney, Nicholas Williamson, Evdokia Dimitriadis, Ellen Menkhorst
Poor pregnancy outcomes such as recurrent pregnancy loss (RPL) and preeclampsia are associated with impaired decidualization and a..
Serum leukotriene B4 and hydroxyeicosatetraenoic acid in the prediction of pre-eclampsia
Leilani L Santos, Dagmar Wertaschnigg, Daniel L Rolnik, Fabricio Da Silva Costa, Argyro Syngelaki, Evdokia Dimitriadis, Kypros H Nicolaides
INTRODUCTION: Pre-eclampsia (PE) affects 2-8% of pregnancies worldwide. Despite identification of numerous possible biomarkers, ac..
Profilin-1 is dysregulated in endometroid (type I) endometrial cancer promoting cell proliferation and inhibiting pro-inflammatory cytokine production
Lisanne George, Amy Winship, Kelli Sorby, Evdokia Dimitriadis, Ellen Menkhorst
Endometrial cancer (EC) is the most common gynaecological malignancy. Alarmingly its incidence and mortality rate is increasing pa..
Galectin-7 Impairs Placentation and Causes Preeclampsia Features in Mice
Ellen Menkhorst, Wei Zhou, Leilani L Santos, Sarah Delforce, Teresa So, Kate Rainczuk, Hannah Loke, Argyro Syngelaki, Swati Varshney, Nicholas Williamson, Kirsty Pringle, Morag J Young, Kypros H Nicolaides, Yves St-Pierre, Eva Dimitriadis
Preeclampsia is a serious pregnancy-induced disorder unique to humans. The etiology of preeclampsia is poorly understood; however,..
Fertile ground: human endometrial programming and lessons in health and disease
Jemma Evans, Lois A Salamonsen, Amy Winship, Ellen Menkhorst, Guiying Nie, Caroline E Gargett, Eva Dimitriadis
The human endometrium is a highly dynamic tissue that is cyclically shed, repaired, regenerated and remodelled, primarily under th..