Critical Regulators of Endometrial Receptivity

Grant number: 1098321 | Funding period: 2018 - 2019

Completed

Abstract

The failure of an embryo to implant is a major cause of infertility. While IVF is an important intervention, still three quarters of embryos do not implant. We have identified new factors that we believe are critically important in embryo attachment to the womb. We will now prove whether these factors are critical and therefore provide the evidence required to begin to develop novel treatment options for infertility.

Related publications (2)

Mouse double minute homologue 2 (MDM2) downregulation by miR-661 impairs human endometrial epithelial cell adhesive capacity

A Winship, A Ton, M Van Sinderen, E Menkhorst, K Rainczuk, M Griffiths, C Cuman, E Dimitriadis

2018-01-01

Human blastocysts that fail to implant following IVF secrete elevated levels of miR-661, which is taken up by primary human endome..

Fertile ground: Human endometrial programming and lessons in health and disease

J Evans, LA Salamonsen, A Winship, E Menkhorst, G Nie, CE Gargett, E Dimitriadis

2016-11-01

The human endometrium is a highly dynamic tissue that is cyclically shed, repaired, regenerated and remodelled, primarily under th..

University of Melbourne Researchers

Evdokia Dimitriadis, Eva Dimitriadis

Ellen Menkhorst