FACILITATING ENDOMETRIAL RECEPTIVITY TO IMPROVE PREGNANCY OUTCOMES
Grant number: 1120689 | Funding period: 2018 - 2021
The womb prepares itself in each menstrual cycle for pregnancy and the implantation of an embryo. In some women, the endometrium may not prepare itself adequately and this can lead to infertility. We have identified small RNA that may be useful in predicting which women are not adequately prepared for implantation and may be used to develop treatments for infertile women, for which there are currently no treatments.
Related publications (6)
miR-29c overexpression and COL4A1 downregulation in infertile human endometrium reduces endometrial epithelial cell adhesive capacity in vitro implying roles in receptivity
Meaghan Griffiths, Michelle Van Sinderen, Katarzyna Rainczuk, Evdokia Dimitriadis
The endometrium is a highly complex tissue that is vulnerable to subtle gene expression changes and is the first point of contact ..