A GLOBAL ALLIANCE TO UNLOCK BRAIN MECHANISMS INFLUENCING SUICIDAL BEHAVIORS THROUGH THE ENIGMA CONSORTIUM

The Enhancing NeuroImaging Genetics through Meta-Analysis Consortium: 10 Years of Global Collaborations in Human Brain Mapping

Paul M Thompson, Neda Jahanshad, Lianne Schmaal, Jessica A Turner, Anderson M Winkler, Sophia I Thomopoulos, Gary F Egan, Peter Kochunov

2021-10-06

This Special Issue of Human Brain Mapping is dedicated to a 10-year anniversary of the Enhancing NeuroImaging Genetics through Met..

Brain aging in major depressive disorder: results from the ENIGMA major depressive disorder working group.

Laura KM Han, Richard Dinga, Tim Hahn, Christopher RK Ching, Lisa T Eyler, Lyubomir Aftanas, Moji Aghajani, André Aleman, Bernhard T Baune, Klaus Berger, Ivan Brak, Geraldo Busatto Filho, Angela Carballedo, Colm G Connolly, Baptiste Couvy-Duchesne, Kathryn R Cullen, Udo Dannlowski, Christopher G Davey, Danai Dima, Fabio LS Duran

2021-09-01

Major depressive disorder (MDD) is associated with an increased risk of brain atrophy, aging-related diseases, and mortality. We e..

Brain Correlates of Suicide Attempt in 18,925 Participants Across 18 International Cohorts

Adrian Campos, Paul M Thompson, Dick J Veltman, Elena Pozzi, Laura S van Veltzen, Neda Jahanshad, Mark J Adams, Bernhard T Baune, Klaus Berger, Katharina Brosch, Robin Bulow, Colm G Connolly, Udo Dannlowski, Christopher G Davey, Greig de Zubicaray, Danai Dima, Tracy Erwin-Grabner, Jennifer W Evans, Cynthia HY Fu, Ian H Gotlib

2021-08-15

BACKGROUND: Neuroimaging studies of suicidal behavior have so far been conducted in small samples, prone to biases and false-posit..

ENIGMA HALFpipe: Interactive, reproducible, and efficient analysis for resting-state and task-based fMRI data

Lea Waller, Susanne Erk, Elena Pozzi, Yara Toenders, Courtney Haswell, Marc Büttner, Paul Thompson, Lianne Schmaal, Rajendra Morey, Henrik Walter, Ilya Veer

2021-05-09

The reproducibility crisis in neuroimaging has led to an increased demand for standardized data processing workflows. Within the E..

Mental images of suicide: Theoretical framework and preliminary findings in depressed youth attending outpatient care

MR De Rozario, LS Van Velzen, P Davies, SM Rice, CG Davey, J Robinson, M Alvarez-Jimenez, K Allott, B McKechnie, KL Felmingham, L Schmaal

2021-04-01

Predicting Depression Onset in Young People Based on Clinical, Cognitive, Environmental, and Neurobiological Data.

Yara J Toenders, Akhil Kottaram, Richard Dinga, Christopher G Davey, Tobias Banaschewski, Arun LW Bokde, Erin Burke Quinlan, Sylvane Desrivières, Herta Flor, Antoine Grigis, Hugh Garavan, Penny Gowland, Andreas Heinz, Rüdiger Brühl, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Frauke Nees, Dimitri Papadopoulos Orfanos, Herve Lemaitre, Tomáš Paus

2021-03-19

BACKGROUND: Adolescent onset of depression is associated with long-lasting negative consequences. Identifying adolescents at risk ..

Accommodating site variation in neuroimaging data using normative and hierarchical Bayesian models

Johanna Bayer, Richard Dinga, Seyed Mostafa Kia, Akhil Kottaram, Thomas Wolfers, Jinglei Lv, Andrew Zalesky, Lianne Schmaal, Andre Marquand

2021-02-11

<h4>A bstract </h4> The potential of normative modeling to make individualized predictions from neuroimaging data has enabled infe..

Mapping cortical and subcortical asymmetries in substance dependence: Findings from the ENIGMA Addiction Working Group

Zhipeng Cao, Jonatan Ottino-Gonzalez, Renata B Cupertino, Nathan Schwab, Colin Hoke, Orr Catherine, Janna Cousijn, Alain Dagher, John J Foxe, Anna E Goudriaan, Robert Hester, Kent Hutchison, Chiang-Shan R Li, Edythe D London, Valentina Lorenzetti, Maartje Luijten, Rocio Martin-Santos, Reza Momenan, Martin P Paulus, Lianne Schmaal

2021-01-28

Brain asymmetry reflects left-right hemispheric differentiation, which is a quantitative brain phenotype that develops with age an..

Structural brain imaging studies offer clues about the effects of the shared genetic etiology among neuropsychiatric disorders

Nevena V Radonjic, Jonathan L Hess, Paula Rovira, Ole Andreassen, Jan K Buitelaar, Christopher RK Ching, Barbara Franke, Martine Hoogman, Neda Jahanshad, Carrie McDonald, Lianne Schmaal, Sanjay M Sisodiya, Dan J Stein, Odile A van den Heuvel, Theo GM van Erp, Daan van Rooij, Dick J Veltman, Paul Thompson, Stephen V Faraone

2021-01-17

Genomewide association studies have found significant genetic correlations among many neuropsychiatric disorders. In contrast, we ..

Comparison of regional brain deficit patterns in common psychiatric and neurological disorders as revealed by big data

Peter Kochunov, Meghann C Ryan, Qifan Yang, Kathryn S Hatch, Alyssa Zhu, Sophia Thomopoulos, Neda Jahanshad, Lianne Schmaal, Paul M Thompson, Shuo Chen, Xiaoming Du, Bhim M Adhikari, Heather Bruce, Stephanie Hare, Eric L Goldwaser, Mark D Kvarta, Thomas E Nichols, L Elliot Hong

2021-01-01

Neurological and psychiatric illnesses are associated with regional brain deficit patterns that bear unique signatures and capture..

Brain structural correlates of insomnia severity in 1053 individuals with major depressive disorder: results from the ENIGMA MDD Working Group

Jeanne Leerssen, Tessa F Blanken, Elena Pozzi, Neda Jahanshad, Lyubomir Aftanas, Ole A Andreassen, Bernhard T Baune, Ivan Brack, Angela Carballedo, Christopher RK Ching, Udo Dannlowski, Katharina Dohm, Verena Enneking, Elena Filimonova, Stella M Fingas, Thomas Frodl, Beata R Godlewska, Janik Goltermann, Ian H Gotlib, Dominik Grotegerd

2020-12-08

It has been difficult to find robust brain structural correlates of the overall severity of major depressive disorder (MDD). We hy..

In vivo hippocampal subfield volumes in bipolar disorder-A mega-analysis from The Enhancing Neuro Imaging Genetics throughMeta-AnalysisBipolar Disorder Working Group

Unn K Haukvik, Tiril P Gurholt, Stener Nerland, Torbjorn Elvsashagen, Theophilus N Akudjedu, Martin Alda, Dag Alnaes, Silvia Alonso-Lana, Jochen Bauer, Bernhard T Baune, Francesco Benedetti, Michael Berk, Francesco Bettella, Erlend Boen, Caterina M Bonnin, Paolo Brambilla, Erick J Canales-Rodriguez, Dara M Cannon, Xavier Caseras, Orwa Dandash

2020-10-19

The hippocampus consists of anatomically and functionally distinct subfields that may be differentially involved in the pathophysi..

Greater male than female variability in regional brain structure across the lifespan

Lara M Wierenga, Gaelle E Doucet, Danai Dima, Ingrid Agartz, Moji Aghajani, Theophilus N Akudjedu, Anton Albajes-Eizagirre, Dag Alnaes, Kathryn Alpert, Ole A Andreassen, Alan Anticevic, Philip Asherson, Tobias Banaschewski, Nuria Bargallo, Sarah Baumeister, Ramona Baur-Streubel, Alessandro Bertolino, Aurora Bonvino, Dorret Boomsma, Stefan Borgwardt

2020-10-12

For many traits, males show greater variability than females, with possible implications for understanding sex differences in heal..

Intracranial and subcortical volumes in adolescents withearly-onsetpsychosis: A multisitemega-analysisfrom theENIGMAconsortium

Tiril P Gurholt, Vera Lonning, Stener Nerland, Kjetil N Jorgensen, Unn K Haukvik, Clara Alloza, Celso Arango, Claudia Barth, Carrie E Bearden, Michael Berk, Hannes Bohman, Orwa Dandash, Covadonga M Diaz-Caneja, Carl T Edbom, Theo GM van Erp, Anne-Kathrin J Fett, Sophia Frangou, Benjamin I Goldstein, Anahit Grigorian, Neda Jahanshad

2020-10-05

Early-onset psychosis disorders are serious mental disorders arising before the age of 18 years. Here, we investigate the largest ..

Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults

Edith Hofer, Gennady V Roshchupkin, Hieab HH Adams, Maria J Knol, Honghuang Lin, Shuo Li, Habil Zare, Shahzad Ahmad, Nicola J Armstrong, Claudia L Satizabal, Manon Bernard, Joshua C Bis, Nathan A Gillespie, Michelle Luciano, Aniket Mishra, Markus Scholz, Alexander Teumer, Rui Xia, Xueqiu Jian, Thomas H Mosley

2020-09-22

Cortical thickness, surface area and volumes vary with age and cognitive function, and in neurological and psychiatric diseases. H..

Imaging suicidal thoughts and behavior: the promise of computational models

Anne-Laura van Harmelen, Lianne Schmaal, Hilary P Blumberg

2020-09-07

Brain structural correlates of insomnia severity in 1053 individuals with major depressive disorder: results from the ENIGMA MDD working group

J Leerssen, TF Blanken, E Pozzi, N Jahanshad, L Aftanas, OA Andreassen, BT Baune, CRK Ching, U Dannlowski, T Frodl, BR Godlewska, IH Gotlib, D Grotegerd, O Gruber, SN Hatton, IB Hickie, N Jaworska, T Kircher, A Krug, J Lagopoulos

2020-09-01

Increased power by harmonizing structural MRI site differences with the ComBat batch method in ENIGMA

Joaquim Radua, Eduard Vieta, Russell Shinohara, Peter Kochunov, Yann Quide, Melissa J Green, Cynthia S Weickert, Thomas Weickert, Jason Bruggemann, Tilo Kircher, Igor Nenadic, Murray J Cairns, Marc Seal, Ulrich Schall, Frans Henskens, Janice M Fullerton, Bryan Mowry, Christos Pantelis, Rhoshel Lenroot, Vanessa Cropley

2020-09-01

A common limitation of neuroimaging studies is their small sample sizes. To overcome this hurdle, the Enhancing Neuro Imaging Gene..

Common andgender-specificassociations with cocaine use on gray matter volume: Data from theENIGMAaddiction working group

Rachel A Rabin, Scott Mackey, Muhammad A Parvaz, Janna Cousijn, Chiang-shan Li, Godfrey Pearlson, Lianne Schmaal, Rajita Sinha, Elliot Stein, Dick Veltman, Paul M Thompson, Patricia Conrod, Hugh Garavan, Nelly Alia-Klein, Rita Z Goldstein

2020-08-28

Gray matter volume (GMV) in frontal cortical and limbic regions is susceptible to cocaine-associated reductions in cocaine-depende..

White matter abnormalities across different epilepsy syndromes in adults: an ENIGMA-Epilepsy study

Sean N Hatton, Khoa H Huynh, Leonardo Bonilha, Eugenio Abela, Saud Alhusaini, Andre Altmann, Marina KM Alvim, Akshara R Balachandra, Emanuele Bartolini, Benjamin Bender, Neda Bernasconi, Andrea Bernasconi, Boris Bernhardt, Nuria Bargallo, Benoit Caldairou, Maria E Caligiuri, Sarah JA Carr, Gianpiero L Cavalleri, Fernando Cendes, Luis Concha

2020-08-01

The epilepsies are commonly accompanied by widespread abnormalities in cerebral white matter. ENIGMA-Epilepsy is a large quantitat..

White matter disturbances in major depressive disorder: a coordinated analysis across 20 international cohorts in the ENIGMA MDD working group

Laura S van Velzen, Sinead Kelly, Dmitry Isaev, Andre Aleman, Lyubomir Aftanas, Jochen Bauer, Bernhard T Baune, Ivan Brak, Angela Carballedo, Colm G Connolly, Baptiste Couvy-Duchesne, Kathryn R Cullen, Konstantin Danilenko, Udo Dannlowski, Verena Enneking, Elena Filimonova, Katharina Foerster, Thomas Frodl, Ian H Gotlib, Nynke A Groenewold

2020-07-01

Alterations in white matter (WM) microstructure have been implicated in the pathophysiology of major depressive disorder (MDD). Ho..

ENIGMA MDD: seven years of global neuroimaging studies of major depression through worldwide data sharing

Lianne Schmaal, Elena Pozzi, Tiffany C Ho, Laura S van Velzen, Ilya M Veer, Nils Opel, Eus JW Van Someren, Laura KM Han, Lybomir Aftanas, Andre Aleman, Bernhard T Baune, Klaus Berger, Tessa F Blanken, Liliana Capitao, Baptiste Couvy-Duchesne, Kathryn R Cullen, Udo Dannlowski, Christopher Davey, Tracy Erwin-Grabner, Jennifer Evans

2020-05-29

A key objective in the field of translational psychiatry over the past few decades has been to identify the brain correlates of ma..

The ENIGMA-Epilepsy working group: Mapping disease from large data sets

Sanjay M Sisodiya, Christopher D Whelan, Sean N Hatton, Khoa Huynh, Andre Altmann, Mina Ryten, Annamaria Vezzani, Maria Eugenia Caligiuri, Angelo Labate, Antonio Gambardella, Victoria Ives-Deliperi, Stefano Meletti, Brent C Munsell, Leonardo Bonilha, Manuela Tondelli, Michael Rebsamen, Christian Rummel, Anna Elisabetta Vaudano, Roland Wiest, Akshara R Balachandra

2020-05-29

Epilepsy is a common and serious neurological disorder, with many different constituent conditions characterized by their electro ..

Brain structural abnormalities in obesity: relation to age, genetic risk, and common psychiatric disorders Evidence through univariate and multivariate mega-analysis including 6420 participants from the ENIGMA MDD working group

Nils Opel, Anbupalam Thalamuthu, Yuri Milaneschi, Dominik Grotegerd, Claas Flint, Ramona Leenings, Janik Goltermann, Maike Richter, Tim Hahn, Georg Woditsch, Klaus Berger, Marco Hermesdorf, Andrew McIntosh, Heather C Whalley, Mathew A Harris, Frank P MacMaster, Henrik Walter, Ilya M Veer, Thomas Frodl, Angela Carballedo

2020-05-28

Emerging evidence suggests that obesity impacts brain physiology at multiple levels. Here we aimed to clarify the relationship bet..

The ENIGMA Stroke Recovery Working Group: Big data neuroimaging to study brain-behavior relationships after stroke

Sook-Lei Liew, Artemis Zavaliangos-Petropulu, Neda Jahanshad, Catherine E Lang, Kathryn S Hayward, Keith R Lohse, Julia M Juliano, Francesca Assogna, Lee A Baugh, Anup K Bhattacharya, Bavrina Bigjahan, Michael R Borich, Lara A Boyd, Amy Brodtmann, Cathrin M Buetefisch, Winston D Byblow, Jessica M Cassidy, Adriana B Conforto, R Cameron Craddock, Michael A Dimyan

2020-04-20

The goal of the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) Stroke Recovery working group is to understand brai..

ENIGMA-DTI: Translating reproducible white matter deficits into personalized vulnerability metrics in cross-diagnostic psychiatric research

Peter Kochunov, L Elliot Hong, Emily L Dennis, Rajendra A Morey, David F Tate, Elisabeth A Wilde, Mark Logue, Sinead Kelly, Gary Donohoe, Pauline Favre, Josselin Houenou, Christopher RK Ching, Laurena Holleran, Ole A Andreassen, Laura S van Velzen, Lianne Schmaal, Julio E Villalon-Reina, Carrie E Bearden, Fabrizio Piras, Gianfranco Spalletta

2020-04-16

The ENIGMA-DTI (diffusion tensor imaging) workgroup supports analyses that examine the effects of psychiatric, neurological, and d..

Subcortical shape alterations in major depressive disorder: Findings from the ENIGMA major depressive disorder working group

Tiffany C Ho, Boris Gutman, Elena Pozzi, Hans J Grabe, Norbert Hosten, Katharina Wittfeld, Henry Voelzke, Bernhard Baune, Udo Dannlowski, Katharina Foerster, Dominik Grotegerd, Ronny Redlich, Andreas Jansen, Tilo Kircher, Axel Krug, Susanne Meinert, Igor Nenadic, Nils Opel, Richard Dinga, Dick J Veltman

2020-03-21

Alterations in regional subcortical brain volumes have been investigated as part of the efforts of an international consortium, EN..

ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries

Paul M Thompson, Neda Jahanshad, Christopher RK Ching, Lauren E Salminen, Sophia I Thomopoulos, Joanna Bright, Bernhard T Baune, Sara Bertolin, Janita Bralten, Willem B Bruin, Robin Buelow, Jian Chen, Yann Chye, Udo Dannlowski, Carolien GF de Kovel, Gary Donohoe, Lisa T Eyler, Stephen V Faraone, Pauline Favre, Courtney A Filippi

2020-03-20

This review summarizes the last decade of work by the ENIGMA (Enhancing NeuroImaging Genetics through Meta Analysis) Consortium, a..

The genetic architecture of the human cerebral cortex

Katrina L Grasby, Neda Jahanshad, Jodie N Painter, Lucia Colodro-Conde, Janita Bralten, Derrek P Hibar, Penelope A Lind, Fabrizio Pizzagalli, Christopher RK Ching, Mary Agnes B McMahon, Natalia Shatokhina, Leo CP Zsembik, Sophia I Thomopoulos, Alyssa H Zhu, Lachlan T Strike, Ingrid Agartz, Saud Alhusaini, Marcio AA Almeida, Dag Alnaes, Inge K Amlien

2020-03-20

The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influen..

An overview of the first 5 years of the ENIGMA obsessive-compulsive disorder working group: The power of worldwide collaboration

Odile A van den Heuvel, Premika SW Boedhoe, Sara Bertolin, Willem B Bruin, Clyde Francks, Iliyan Ivanov, Neda Jahanshad, Xiang-Zhen Kong, Jun S Kwon, Joseph O'Neill, Tomas Paus, Yash Patel, Fabrizio Piras, Lianne Schmaal, Carles Soriano-Mas, Gianfranco Spalletta, Guido A van Wingen, Je-Yeon Yun, Chris Vriend, H Blair Simpson

2020-03-10

Neuroimaging has played an important part in advancing our understanding of the neurobiology of obsessive-compulsive disorder (OCD..

Imaging suicidal thoughts and behaviors: a comprehensive review of 2 decades of neuroimaging studies

Lianne Schmaal, Anne-Laura van Harmelen, Vasiliki Chatzi, Elizabeth TC Lippard, Yara J Toenders, Lynnette A Averill, Carolyn M Mazure, Hilary P Blumberg

2020-02-01

Identifying brain alterations that contribute to suicidal thoughts and behaviors (STBs) are important to develop more targeted and..

Widespread white matter microstructural abnormalities in bipolar disorder: evidence from mega- and meta-analyses across 3033 individuals

Pauline Favre, Melissa Pauling, Jacques Stout, Franz Hozer, Samuel Sarrazin, Christoph Abe, Martin Alda, Clara Alloza, Silvia Alonso-Lana, Ole A Andreassen, Bernhard T Baune, Francesco Benedetti, Geraldo F Busatto, Erick J Canales-Rodriguez, Xavier Caseras, Tiffany Moukbel Chaim-Avancini, Christopher RK Ching, Udo Dannlowski, Michael Deppe, Lisa T Eyler

2019-12-01

Fronto-limbic white matter (WM) abnormalities are assumed to lie at the heart of the pathophysiology of bipolar disorder (BD); how..

Genetic architecture of subcortical brain structures in 38,851 individuals

Claudia L Satizabal, Hieab HH Adams, Derrek P Hibar, Charles C White, Maria J Knol, Jason L Stein, Markus Scholz, Muralidharan Sargurupremraj, Neda Jahanshad, Gennady Roshchupkin, Albert Smith, Joshua C Bis, Xueqiu Jian, Michelle Luciano, Edith Hofer, Alexander Teumer, Sven J van der Lee, Jingyun Yang, Lisa R Yanek, Tom Lee

2019-11-01

Subcortical brain structures are integral to motion, consciousness, emotions and learning. We identified common genetic variation ..

Neuroimaging predictors of onset and course of depression in childhood and adolescence: A systematic review of longitudinal studies

Yara J Toenders, Laura S van Velzen, Ivonne Z Heideman, Ben J Harrison, Christopher G Davey, Lianne Schmaal

2019-10-01

Major depressive disorder (MDD) often emerges during adolescence with detrimental effects on development as well as lifetime conse..

Journal of Affective Disorders Special Issue on Suicide-Related Research: Hopeful progress but much research urgently needed

A-L Van Harmelen, L Schmaal, HP Blumberg

2019-05-15

Mega-Analysis of Gray Matter Volume in Substance Dependence: General and Substance-Specific Regional Effects

Scott Mackey, Nicholas Allgaier, Bader Chaarani, Philip Spechler, Catherine Orr, Janice Bunn, Nicholas B Allen, Nelly Alia-Klein, Albert Batalla, Sara Blaine, Samantha Brooks, Elisabeth Caparelli, Yann Ying Chye, Janna Cousijn, Alain Dagher, Sylvane Desrivieres, Sarah Feldstein-Ewing, John J Foxe, Rita Z Goldstein, Anna E Goudriaan

2019-02-01

OBJECTIVE: Although lower brain volume has been routinely observed in individuals with substance dependence compared with nondepen..

An Empirical Comparison of Meta- and Mega-Analysis With Data From the ENIGMA Obsessive-Compulsive Disorder Working Group

Premika SW Boedhoe, Martijn W Heymans, Lianne Schmaal, Yoshinari Abe, Pino Alonso, Stephanie H Ameis, Alan Anticevic, Paul D Arnold, Marcelo C Batistuzzo, Francesco Benedetti, Jan C Beucke, Irene Bollettini, Anushree Bose, Silvia Brem, Anna Calvo, Rosa Calvo, Yuqi Cheng, Kang lk K Cho, Valentina Ciullo, Sara Dallaspezia

2019-01-08

Objective: Brain imaging communities focusing on different diseases have increasingly started to collaborate and to pool data to p..

Subcortical brain structure and suicidal behaviour in major depressive disorder: a meta-analysis from the ENIGMA-MDD working group

ME Renteria, L Schmaal, DP Hibar, B Couvy-Duchesne, LT Strike, NT Mills, GI de Zubicaray, KL McMahon, SE Medland, NA Gillespie, SN Hatton, J Lagopoulos, DJ Veltman, N van der Wee, TGM van Erp, K Wittfeld, HJ Grabe, A Block, K Hegenscheid, H Voelzke

2017-05-02

The aetiology of suicidal behaviour is complex, and knowledge about its neurobiological mechanisms is limited. Neuroimaging method..

Subcortical Brain Alterations in Major Depressive Disorder: Findings from the ENIGMA Major Depressive Disorder Working Group

Lianne Schmaal, Dick J Veltman, Theo GM van Erp, Brenda WJH Penninx, Paul M Thompson, Derrek P Hibar

2015-05-01

Alterations in regional subcortical brain volumes have been widely investigated as part of the efforts of an international consort..