A GLOBAL ALLIANCE TO UNLOCK BRAIN MECHANISMS INFLUENCING SUICIDAL BEHAVIORS THROUGH THE ENIGMA CONSORTIUM
Grant number: R01MH117601 / 108606875 | Funding period: 2018 - 2023
ABSTRACT One million people around the world die from suicide annually. Suicide is the tenth leading cause of death for all ages and the second leading cause of death among young people with mental disorders. More people under the age of 55 die by suicide than from HIV, stroke, influenza, respiratory diseases, chronic lung disease and homicide. There are at least 20 suicide attempts for every completed suicide. Better prevention strategies are urgently needed; yet, mechanisms that confer increased risk for suicidal behaviors (ranging from suicidal ideation to suicide attempts and completed suicide) remain largely unknown. Neurobiological alterations associated with a history of suicidal thou..View full description
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Identifying brain alterations that contribute to suicidal thoughts and behaviors (STBs) are important to develop more targeted and..
Widespread white matter microstructural abnormalities in bipolar disorder: evidence from mega- and meta-analyses across 3033 individuals
Pauline Favre, Melissa Pauling, Jacques Stout, Franz Hozer, Samuel Sarrazin, Christoph Abe, Martin Alda, Clara Alloza, Silvia Alonso-Lana, Ole A Andreassen, Bernhard T Baune, Francesco Benedetti, Geraldo F Busatto, Erick J Canales-Rodriguez, Xavier Caseras, Tiffany Moukbel Chaim-Avancini, Christopher RK Ching, Udo Dannlowski, Michael Deppe, Lisa T Eyler
Fronto-limbic white matter (WM) abnormalities are assumed to lie at the heart of the pathophysiology of bipolar disorder (BD); how..
Genetic architecture of subcortical brain structures in 38,851 individuals
Claudia L Satizabal, Hieab HH Adams, Derrek P Hibar, Charles C White, Maria J Knol, Jason L Stein, Markus Scholz, Muralidharan Sargurupremraj, Neda Jahanshad, Gennady Roshchupkin, Albert Smith, Joshua C Bis, Xueqiu Jian, Michelle Luciano, Edith Hofer, Alexander Teumer, Sven J van der Lee, Jingyun Yang, Lisa R Yanek, Tom Lee
Subcortical brain structures are integral to motion, consciousness, emotions and learning. We identified common genetic variation ..
ENIGMA MDD: Seven Years of Global Neuroimaging Studies of Major Depression through Worldwide Data Sharing
Lianne Schmaal, Elena Pozzi, Tiffany Ho, Laura S van Velzen, Ilya Veer, Nils Opel, Eus Van Someren, Laura KM Han, Lybomir Aftanas, Andre Aleman, Bernhard T Baune, Klaus Berger, Tessa Blanken, Liliana Capitao, Baptiste Couvy-Duchesne, Kathryn R Cullen, Udo Dannlowski, Christopher Davey, Tracy Erwin-Grabner, Jennifer Evans
<p>A key objective in the field of translational psychiatry over the past few decades has been to identify the brain correlates co..
Neuroimaging predictors of onset and course of depression in childhood and adolescence: A systematic review of longitudinal studies
Yara J Toenders, Laura S van Velzen, Ivonne Z Heideman, Ben J Harrison, Christopher G Davey, Lianne Schmaal
Major depressive disorder (MDD) often emerges during adolescence with detrimental effects on development as well as lifetime conse..
Mega-Analysis of Gray Matter Volume in Substance Dependence: General and Substance-Specific Regional Effects
Scott Mackey, Nicholas Allgaier, Bader Chaarani, Philip Spechler, Catherine Orr, Janice Bunn, Nicholas B Allen, Nelly Alia-Klein, Albert Batalla, Sara Blaine, Samantha Brooks, Elisabeth Caparelli, Yann Ying Chye, Janna Cousijn, Alain Dagher, Sylvane Desrivieres, Sarah Feldstein-Ewing, John J Foxe, Rita Z Goldstein, Anna E Goudriaan
OBJECTIVE: Although lower brain volume has been routinely observed in individuals with substance dependence compared with nondepen..
An Empirical Comparison of Meta- and Mega-Analysis With Data From the ENIGMA Obsessive-Compulsive Disorder Working Group
Premika SW Boedhoe, Martijn W Heymans, Lianne Schmaal, Yoshinari Abe, Pino Alonso, Stephanie H Ameis, Alan Anticevic, Paul D Arnold, Marcelo C Batistuzzo, Francesco Benedetti, Jan C Beucke, Irene Bollettini, Anushree Bose, Silvia Brem, Anna Calvo, Rosa Calvo, Yuqi Cheng, Kang lk K Cho, Valentina Ciullo, Sara Dallaspezia
Objective: Brain imaging communities focusing on different diseases have increasingly started to collaborate and to pool data to p..
Subcortical brain structure and suicidal behaviour in major depressive disorder: a meta-analysis from the ENIGMA-MDD working group
ME Renteria, L Schmaal, DP Hibar, B Couvy-Duchesne, LT Strike, NT Mills, GI de Zubicaray, KL McMahon, SE Medland, NA Gillespie, SN Hatton, J Lagopoulos, DJ Veltman, N van der Wee, TGM van Erp, K Wittfeld, HJ Grabe, A Block, K Hegenscheid, H Voelzke
The aetiology of suicidal behaviour is complex, and knowledge about its neurobiological mechanisms is limited. Neuroimaging method..