A GLOBAL ALLIANCE TO UNLOCK BRAIN MECHANISMS INFLUENCING SUICIDAL BEHAVIORS THROUGH THE ENIGMA CONSORTIUM

Elevated cognitive rumination and adverse life events are associated with lower cortical surface area and suicidal ideation in adolescents with major depressive disorder.

Maria R Dauvermann, Lianne Schmaal, Lejla Colic, Laura S van Velzen, Sophie Bellow, Tamsin J Ford, John Suckling, Ian M Goodyer, null IMPACT Consortium, Hilary P Blumberg, Anne-Laura van Harmelen

2023-03-15

INTRODUCTION: Suicide is the second most common cause of death among young people. Structural brain alterations, rumination, and r..

In vivo white matter microstructure in adolescents with early-onset psychosis: a multi-site mega-analysis.

Claudia Barth, Sinead Kelly, Stener Nerland, Neda Jahanshad, Clara Alloza, Sonia Ambrogi, Ole A Andreassen, Dimitrios Andreou, Celso Arango, Inmaculada Baeza, Nerisa Banaj, Carrie E Bearden, Michael Berk, Hannes Bohman, Josefina Castro-Fornieles, Yann Chye, Benedicto Crespo-Facorro, Elena de la Serna, Covadonga M Díaz-Caneja, Tiril P Gurholt

2023-03-01

Emerging evidence suggests brain white matter alterations in adolescents with early-onset psychosis (EOP; age of onset <18 years)...

Brain deficit patterns of metabolic illnesses overlap with those for major depressive disorder: A new metric of brain metabolic disease.

Kathryn S Hatch, Si Gao, Yizhou Ma, Alessandro Russo, Neda Jahanshad, Paul M Thompson, Bhim M Adhikari, Heather Bruce, Andrew Van der Vaart, Aristeidis Sotiras, Mark D Kvarta, Thomas E Nichols, Lianne Schmaal, L Elliot Hong, Peter Kochunov

2023-02-17

Metabolic illnesses (MET) are detrimental to brain integrity and are common comorbidities in patients with mental illnesses, inclu..

Cortical profiles of numerous psychiatric disorders and normal development share a common pattern.

Zhipeng Cao, Renata B Cupertino, Jonatan Ottino-Gonzalez, Alistair Murphy, Devarshi Pancholi, Anthony Juliano, Bader Chaarani, Matthew Albaugh, Dekang Yuan, Nathan Schwab, James Stafford, Anna E Goudriaan, Kent Hutchison, Chiang-Shan R Li, Maartje Luijten, Martine Groefsema, Reza Momenan, Lianne Schmaal, Rajita Sinha, Ruth J van Holst

2023-02-01

The neurobiological bases of the association between development and psychopathology remain poorly understood. Here, we identify a..

Brain ageing in schizophrenia: evidence from 26 international cohorts via the ENIGMA Schizophrenia consortium.

Constantinos Constantinides, Laura KM Han, Clara Alloza, Linda Antonella Antonucci, Celso Arango, Rosa Ayesa-Arriola, Nerisa Banaj, Alessandro Bertolino, Stefan Borgwardt, Jason Bruggemann, Juan Bustillo, Oleg Bykhovski, Vince Calhoun, Vaughan Carr, Stanley Catts, Young-Chul Chung, Benedicto Crespo-Facorro, Covadonga M Díaz-Caneja, Gary Donohoe, Stefan Du Plessis

2022-12-09

Schizophrenia (SZ) is associated with an increased risk of life-long cognitive impairments, age-related chronic disease, and prema..

A large-scale ENIGMA multisite replication study of brain age in depression

Laura KM Han, Richard Dinga, Ramona Leenings, Tim Hahn, James H Cole, Lyubomir I Aftanas, Alyssa R Amod, Bianca Besteher, Romain Colle, Emmanuelle Corruble, Baptiste Couvy-Duchesne, Konstantin V Danilenko, Paola Fuentes-Claramonte, Ali Saffet Gonul, Ian H Gotlib, Roberto Goya-Maldonado, Nynke A Groenewold, Paul Hamilton, Naho Ichikawa, Jonathan C Ipser

2022-12-01

Background: Several studies have evaluated whether depressed persons have older appearing brains than their nondepressed peers. Ho..

Brain grey and white matter structural associations with future suicidal ideation and behaviors in adolescent and young adult females with mood disorders.

Lejla Colic, Luca M Villa, Maria R Dauvermann, Laura S van Velzen, Anjali Sankar, Danielle A Goldman, Priyanka Panchal, Jihoon A Kim, Susan Quatrano, Linda Spencer, R Todd Constable, John Suckling, Ian M Goodyer, Lianne Schmaal, Anne-Laura van Harmelen, Hilary P Blumberg

2022-12-01

BACKGROUND: To reduce suicide in females with mood disorders, it is critical to understand brain substrates underlying their vulne..

A comparison of methods to harmonize cortical thickness measurements across scanners and sites.

Delin Sun, Gopalkumar Rakesh, Courtney C Haswell, Mark Logue, C Lexi Baird, Erin N O'Leary, Andrew S Cotton, Hong Xie, Marijo Tamburrino, Tian Chen, Emily L Dennis, Neda Jahanshad, Lauren E Salminen, Sophia I Thomopoulos, Faisal Rashid, Christopher RK Ching, Saskia BJ Koch, Jessie L Frijling, Laura Nawijn, Mirjam van Zuiden

2022-11-01

Results of neuroimaging datasets aggregated from multiple sites may be biased by site-specific profiles in participants' demograph..

Accommodating site variation in neuroimaging data using normative and

Johanna MM Bayer, Richard Dinga, Seyed Mostafa Kia, Akhil R Kottaram, Thomas Wolfers, Jinglei Lv, Andrew Zalesky, Lianne Schmaal, Andre Marquand

2022-10-29

The potential of normative modeling to make individualized predictions from neuroimaging data has enabled inferences that go beyon..

Multiscale neural gradients reflect transdiagnostic effects of major psychiatric conditions on cortical morphology

Bo-yong Park, Valeria Kebets, Sara Lariviere, Meike D Hettwer, Casey Paquola, Daan van Rooij, Jan Buitelaar, Barbara Franke, Martine Hoogman, Lianne Schmaal, Dick J Veltman, Odile van den Heuvel, Dan J Stein, Ole A Andreassen, Christopher RK Ching, Jessica Turner, Theo GM van Erp, Alan C Evans, Alain Dagher, Sophia Thomopoulos

2022-09-27

It is increasingly recognized that multiple psychiatric conditions are underpinned by shared neural pathways, affecting similar br..

Structural brain alterations associated with suicidal thoughts and behaviors in young people: results from 21 international studies from the ENIGMA Suicidal Thoughts and Behaviours consortium

Laura S van Velzen, Maria R Dauvermann, Lejla Colic, Luca M Villa, Hannah S Savage, Yara J Toenders, Alyssa H Zhu, Joanna K Bright, Adrian Campos, Lauren E Salminen, Sonia Ambrogi, Rosa Ayesa-Arriola, Nerisa Banaj, Zeynep Basgoze, Jochen Bauer, Karina Blair, Robert James Blair, Katharina Brosch, Yuqi Cheng, Romain Colle

2022-09-07

Identifying brain alterations associated with suicidal thoughts and behaviors (STBs) in young people is critical to understanding ..

Remodeling of the Cortical Structural Connectome in Posttraumatic Stress Disorder: Results From the ENIGMA-PGC Posttraumatic Stress Disorder Consortium.

Delin Sun, Gopalkumar Rakesh, Emily K Clarke-Rubright, Courtney C Haswell, Mark W Logue, Erin N O'Leary, Andrew S Cotton, Hong Xie, Emily L Dennis, Neda Jahanshad, Lauren E Salminen, Sophia I Thomopoulos, Faisal M Rashid, Christopher RK Ching, Saskia BJ Koch, Jessie L Frijling, Laura Nawijn, Mirjam van Zuiden, Xi Zhu, Benjamin Suarez-Jimenez

2022-09-01

BACKGROUND: Posttraumatic stress disorder (PTSD) is accompanied by disrupted cortical neuroanatomy. We investigated alteration in ..

Local molecular and global connectomic contributions to cross-disorder cortical abnormalities.

Justine Y Hansen, Golia Shafiei, Jacob W Vogel, Kelly Smart, Carrie E Bearden, Martine Hoogman, Barbara Franke, Daan van Rooij, Jan Buitelaar, Carrie R McDonald, Sanjay M Sisodiya, Lianne Schmaal, Dick J Veltman, Odile A van den Heuvel, Dan J Stein, Theo GM van Erp, Christopher RK Ching, Ole A Andreassen, Tomas Hajek, Nils Opel

2022-08-10

Numerous brain disorders demonstrate structural brain abnormalities, which are thought to arise from molecular perturbations or co..

The role of educational attainment and brain morphology in major depressive disorder: Findings from the ENIGMA major depressive disorder consortium.

Sarah Whittle, Divyangana Rakesh, Lianne Schmaal, Dick J Veltman, Paul M Thompson, Aditya Singh, Ali Saffet Gonul, Andre Aleman, Aslıhan Uyar Demir, Axel Krug, Benson Mwangi, Bernd Krämer, Bernhard T Baune, Dan J Stein, Dominik Grotegerd, Edith Pomarol-Clotet, Elena Rodríguez-Cano, Elisa Melloni, Francesco Benedetti, Frederike Stein

2022-08-01

Brain structural abnormalities and low educational attainment are consistently associated with major depressive disorder (MDD), ye..

Virtual Ontogeny of Cortical Growth Preceding Mental Illness

Yash Patel, Jean Shin, Christoph Abe, Ingrid Agartz, Clara Alloza, Dag Alnaes, Sonia Ambrogi, Linda A Antonucci, Celso Arango, Volker Arolt, Guillaume Auzias, Rosa Ayesa-Arriola, Nerisa Banaj, Tobias Banaschewski, Cibele Bandeira, Zeynep Basgoze, Renata Basso Cupertino, Claiton HD Bau, Jochen Bauer, Sarah Baumeister

2022-07-25

BACKGROUND: Morphology of the human cerebral cortex differs across psychiatric disorders, with neurobiology and developmental orig..

Event-based modeling in temporal lobe epilepsy demonstrates progressive atrophy from cross-sectional data

Seymour M Lopez, Leon M Aksman, Neil P Oxtoby, Sjoerd B Vos, Jun Rao, Erik Kaestner, Saud Alhusaini, Marina Alvim, Benjamin Bender, Andrea Bernasconi, Neda Bernasconi, Boris Bernhardt, Leonardo Bonilha, Lorenzo Caciagli, Benoit Caldairou, Maria Eugenia Caligiuri, Angels Calvet, Fernando Cendes, Luis Concha, Estefania Conde-Blanco

2022-06-25

OBJECTIVE: Recent work has shown that people with common epilepsies have characteristic patterns of cortical thinning, and that th..

Predicting Depression Onset in Young People Based on Clinical, Cognitive, Environmental, and Neurobiological Data

Yara J Toenders, Akhil Kottaram, Richard Dinga, Christopher G Davey, Tobias Banaschewski, Arun LW Bokde, Erin Burke Quinlan, Sylvane Desrivieres, Herta Flor, Antoine Grigis, Hugh Garavan, Penny Gowland, Andreas Heinz, Rudiger Bruehl, Jean-Luc Martinot, Marie-Laure Paillere Martinot, Frauke Nees, Dimitri Papadopoulos Orfanos, Herve Lemaitre, Tomas Paus

2022-04-05

BACKGROUND: Adolescent onset of depression is associated with long-lasting negative consequences. Identifying adolescents at risk ..

Classification of suicidal thoughts and behaviour in children: results from penalised logistic regression analyses in the Adolescent Brain Cognitive Development study

Laura S van Velzen, Yara J Toenders, Aina Avila-Parcet, Richard Dinga, Jill A Rabinowitz, Adrian Campos, Neda Jahanshad, Miguel E Renteria, Lianne Schmaal

2022-04-01

BACKGROUND: Despite efforts to predict suicide risk in children, the ability to reliably identify who will engage in suicide thoug..

Genetic variants associated with longitudinal changes in brain structure across the lifespan

Rachel M Brouwer, Marieke Klein, Katrina L Grasby, Hugo G Schnack, Neda Jahanshad, Jalmar Teeuw, Sophia I Thomopoulos, Emma Sprooten, Carol E Franz, Nitin Gogtay, William S Kremen, Matthew S Panizzon, Loes M Olde Loohuis, Christopher D Whelan, Moji Aghajani, Clara Alloza, Dag Alanaes, Eric Artiges, Rosa Ayesa-Arriola, Gareth J Barker

2022-04-01

Human brain structure changes throughout the lifespan. Altered brain growth or rates of decline are implicated in a vast range of ..

ENIGMA HALFpipe: Interactive, reproducible, and efficient analysis for resting-state and task-based fMRI data

Lea Waller, Susanne Erk, Elena Pozzi, Yara J Toenders, Courtney C Haswell, Marc Buettner, Paul M Thompson, Lianne Schmaal, Rajendra A Morey, Henrik Walter, Ilya M Veer

2022-03-19

The reproducibility crisis in neuroimaging has led to an increased demand for standardized data processing workflows. Within the E..

Cross disorder comparisons of brain structure in schizophrenia, bipolar disorder, major depressive disorder, and 22q11.2 deletion syndrome: A review of ENIGMA findings

Eun-Jin Cheon, Carrie E Bearden, Daqiang Sun, Christopher RK Ching, Ole A Andreassen, Lianne Schmaal, Dick J Veltman, Sophia Thomopoulos, Peter Kochunov, Neda Jahanshad, Paul M Thompson, Jessica A Turner, Theo GM van Erp

2022-02-26

This review compares the main brain abnormalities in schizophrenia (SZ), bipolar disorder (BD), major depressive disorder (MDD), a..

Site effects how-to and when: An overview of retrospective techniques to accommodate site effects in multi-site neuroimaging analyses.

Johanna MM Bayer, Paul M Thompson, Christopher RK Ching, Mengting Liu, Andrew Chen, Alana C Panzenhagen, Neda Jahanshad, Andre Marquand, Lianne Schmaal, Philipp G Sämann

2022-01-31

Site differences, or systematic differences in feature distributions across multiple data-acquisition sites, are a known source of..

Trauma and posttraumatic stress disorder modulate polygenic predictors of hippocampal and amygdala volume.

Yuanchao Zheng, Melanie E Garrett, Delin Sun, Emily K Clarke-Rubright, Courtney C Haswell, Adam X Maihofer, Jeremy A Elman, Carol E Franz, Michael J Lyons, William S Kremen, Matthew Peverill, Kelly Sambrook, Katie A McLaughlin, Nicholas D Davenport, Seth Disner, Scott R Sponheim, Elpiniki Andrew, Mayuresh Korgaonkar, Richard Bryant, Tim Varkevisser

2021-12-16

The volume of subcortical structures represents a reliable, quantitative, and objective phenotype that captures genetic effects, e..

The Enhancing NeuroImaging Genetics through Meta-Analysis Consortium: 10 Years of Global Collaborations in Human Brain Mapping

Paul M Thompson, Neda Jahanshad, Lianne Schmaal, Jessica A Turner, Anderson M Winkler, Sophia I Thomopoulos, Gary F Egan, Peter Kochunov

2021-10-06

This Special Issue of Human Brain Mapping is dedicated to a 10-year anniversary of the Enhancing NeuroImaging Genetics through Met..

Brain aging in major depressive disorder: results from the ENIGMA major depressive disorder working group.

Laura KM Han, Richard Dinga, Tim Hahn, Christopher RK Ching, Lisa T Eyler, Lyubomir Aftanas, Moji Aghajani, André Aleman, Bernhard T Baune, Klaus Berger, Ivan Brak, Geraldo Busatto Filho, Angela Carballedo, Colm G Connolly, Baptiste Couvy-Duchesne, Kathryn R Cullen, Udo Dannlowski, Christopher G Davey, Danai Dima, Fabio LS Duran

2021-09-01

Major depressive disorder (MDD) is associated with an increased risk of brain atrophy, aging-related diseases, and mortality. We e..

Altered white matter microstructural organization in posttraumatic stress disorder across 3047 adults: results from the PGC-ENIGMA PTSD consortium.

Emily L Dennis, Seth G Disner, Negar Fani, Lauren E Salminen, Mark Logue, Emily K Clarke, Courtney C Haswell, Christopher L Averill, Lee A Baugh, Jessica Bomyea, Steven E Bruce, Jiook Cha, Kyle Choi, Nicholas D Davenport, Maria Densmore, Stefan du Plessis, Gina L Forster, Jessie L Frijling, Atilla Gonenc, Staci Gruber

2021-08-01

A growing number of studies have examined alterations in white matter organization in people with posttraumatic stress disorder (P..

Brain Correlates of Suicide Attempt in 18,925 Participants Across 18 International Cohorts

Adrian Campos, Paul M Thompson, Dick J Veltman, Elena Pozzi, Laura S van Veltzen, Neda Jahanshad, Mark J Adams, Bernhard T Baune, Klaus Berger, Katharina Brosch, Robin Bulow, Colm G Connolly, Udo Dannlowski, Christopher G Davey, Greig de Zubicaray, Danai Dima, Tracy Erwin-Grabner, Jennifer W Evans, Cynthia HY Fu, Ian H Gotlib

2021-07-26

BACKGROUND: Neuroimaging studies of suicidal behavior have so far been conducted in small samples, prone to biases and false-posit..

Mental images of suicide: Theoretical framework and preliminary findings in depressed youth attending outpatient care.

MR De Rozario, LS Van Velzen, P Davies, SM Rice, CG Davey, J Robinson, M Alvarez-Jimenez, K Allott, B McKechnie, KL Felmingham, L Schmaal

2021-04-01

Comparison of regional brain deficit patterns in common psychiatric and neurological disorders as revealed by big data

Peter Kochunov, Meghann C Ryan, Qifan Yang, Kathryn S Hatch, Alyssa Zhu, Sophia Thomopoulos, Neda Jahanshad, Lianne Schmaal, Paul M Thompson, Shuo Chen, Xiaoming Du, Bhim M Adhikari, Heather Bruce, Stephanie Hare, Eric L Goldwaser, Mark D Kvarta, Thomas E Nichols, L Elliot Hong

2021-01-30

Neurological and psychiatric illnesses are associated with regional brain deficit patterns that bear unique signatures and capture..

Mapping cortical and subcortical asymmetries in substance dependence: Findings from the ENIGMA Addiction Working Group

Zhipeng Cao, Jonatan Ottino-Gonzalez, Renata B Cupertino, Nathan Schwab, Colin Hoke, Orr Catherine, Janna Cousijn, Alain Dagher, John J Foxe, Anna E Goudriaan, Robert Hester, Kent Hutchison, Chiang-Shan R Li, Edythe D London, Valentina Lorenzetti, Maartje Luijten, Rocio Martin-Santos, Reza Momenan, Martin P Paulus, Lianne Schmaal

2021-01-28

Brain asymmetry reflects left-right hemispheric differentiation, which is a quantitative brain phenotype that develops with age an..

Structural brain imaging studies offer clues about the effects of the shared genetic etiology among neuropsychiatric disorders

Nevena V Radonjic, Jonathan L Hess, Paula Rovira, Ole Andreassen, Jan K Buitelaar, Christopher RK Ching, Barbara Franke, Martine Hoogman, Neda Jahanshad, Carrie McDonald, Lianne Schmaal, Sanjay M Sisodiya, Dan J Stein, Odile A van den Heuvel, Theo GM van Erp, Daan van Rooij, Dick J Veltman, Paul Thompson, Stephen V Faraone

2021-01-17

Genomewide association studies have found significant genetic correlations among many neuropsychiatric disorders. In contrast, we ..

Brain structural correlates of insomnia severity in 1053 individuals with major depressive disorder: results from the ENIGMA MDD Working Group

Jeanne Leerssen, Tessa F Blanken, Elena Pozzi, Neda Jahanshad, Lyubomir Aftanas, Ole A Andreassen, Bernhard T Baune, Ivan Brack, Angela Carballedo, Christopher RK Ching, Udo Dannlowski, Katharina Dohm, Verena Enneking, Elena Filimonova, Stella M Fingas, Thomas Frodl, Beata R Godlewska, Janik Goltermann, Ian H Gotlib, Dominik Grotegerd

2020-12-08

It has been difficult to find robust brain structural correlates of the overall severity of major depressive disorder (MDD). We hy..

Cortical volume abnormalities in posttraumatic stress disorder: an ENIGMA-psychiatric genomics consortium PTSD workgroup mega-analysis

Xin Wang, Hong Xie, Tian Chen, Andrew S Cotton, Lauren E Salminen, Mark W Logue, Emily K Clarke-Rubright, John Wall, Emily L Dennis, Brian M O'Leary, Chadi G Abdallah, Elpiniki Andrew, Lee A Baugh, Jessica Bomyea, Steven E Bruce, Richard Bryant, Kyle Choi, Judith K Daniels, Nicholas D Davenport, Richard J Davidson

2020-12-07

Studies of posttraumatic stress disorder (PTSD) report volume abnormalities in multiple regions of the cerebral cortex. However, f..

In vivo hippocampal subfield volumes in bipolar disorder-A mega-analysis from The Enhancing Neuro Imaging Genetics throughMeta-AnalysisBipolar Disorder Working Group

Unn K Haukvik, Tiril P Gurholt, Stener Nerland, Torbjorn Elvsashagen, Theophilus N Akudjedu, Martin Alda, Dag Alnaes, Silvia Alonso-Lana, Jochen Bauer, Bernhard T Baune, Francesco Benedetti, Michael Berk, Francesco Bettella, Erlend Boen, Caterina M Bonnin, Paolo Brambilla, Erick J Canales-Rodriguez, Dara M Cannon, Xavier Caseras, Orwa Dandash

2020-10-19

The hippocampus consists of anatomically and functionally distinct subfields that may be differentially involved in the pathophysi..

Greater male than female variability in regional brain structure across the lifespan

Lara M Wierenga, Gaelle E Doucet, Danai Dima, Ingrid Agartz, Moji Aghajani, Theophilus N Akudjedu, Anton Albajes-Eizagirre, Dag Alnaes, Kathryn Alpert, Ole A Andreassen, Alan Anticevic, Philip Asherson, Tobias Banaschewski, Nuria Bargallo, Sarah Baumeister, Ramona Baur-Streubel, Alessandro Bertolino, Aurora Bonvino, Dorret Boomsma, Stefan Borgwardt

2020-10-12

For many traits, males show greater variability than females, with possible implications for understanding sex differences in heal..

Intracranial and subcortical volumes in adolescents withearly-onsetpsychosis: A multisitemega-analysisfrom theENIGMAconsortium

Tiril P Gurholt, Vera Lonning, Stener Nerland, Kjetil N Jorgensen, Unn K Haukvik, Clara Alloza, Celso Arango, Claudia Barth, Carrie E Bearden, Michael Berk, Hannes Bohman, Orwa Dandash, Covadonga M Diaz-Caneja, Carl T Edbom, Theo GM van Erp, Anne-Kathrin J Fett, Sophia Frangou, Benjamin I Goldstein, Anahit Grigorian, Neda Jahanshad

2020-10-05

Early-onset psychosis disorders are serious mental disorders arising before the age of 18 years. Here, we investigate the largest ..

Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults

Edith Hofer, Gennady V Roshchupkin, Hieab HH Adams, Maria J Knol, Honghuang Lin, Shuo Li, Habil Zare, Shahzad Ahmad, Nicola J Armstrong, Claudia L Satizabal, Manon Bernard, Joshua C Bis, Nathan A Gillespie, Michelle Luciano, Aniket Mishra, Markus Scholz, Alexander Teumer, Rui Xia, Xueqiu Jian, Thomas H Mosley

2020-09-22

Cortical thickness, surface area and volumes vary with age and cognitive function, and in neurological and psychiatric diseases. H..

Imaging suicidal thoughts and behavior: the promise of computational models

Anne-Laura van Harmelen, Lianne Schmaal, Hilary P Blumberg

2020-09-07

Brain structural correlates of insomnia severity in 1053 individuals with major depressive disorder: results from the ENIGMA MDD working group

J Leerssen, TF Blanken, E Pozzi, N Jahanshad, L Aftanas, OA Andreassen, BT Baune, CRK Ching, U Dannlowski, T Frodl, BR Godlewska, IH Gotlib, D Grotegerd, O Gruber, SN Hatton, IB Hickie, N Jaworska, T Kircher, A Krug, J Lagopoulos

2020-09-01

Increased power by harmonizing structural MRI site differences with the ComBat batch method in ENIGMA

Joaquim Radua, Eduard Vieta, Russell Shinohara, Peter Kochunov, Yann Quide, Melissa J Green, Cynthia S Weickert, Thomas Weickert, Jason Bruggemann, Tilo Kircher, Igor Nenadic, Murray J Cairns, Marc Seal, Ulrich Schall, Frans Henskens, Janice M Fullerton, Bryan Mowry, Christos Pantelis, Rhoshel Lenroot, Vanessa Cropley

2020-09-01

A common limitation of neuroimaging studies is their small sample sizes. To overcome this hurdle, the Enhancing Neuro Imaging Gene..

Common andgender-specificassociations with cocaine use on gray matter volume: Data from theENIGMAaddiction working group

Rachel A Rabin, Scott Mackey, Muhammad A Parvaz, Janna Cousijn, Chiang-shan Li, Godfrey Pearlson, Lianne Schmaal, Rajita Sinha, Elliot Stein, Dick Veltman, Paul M Thompson, Patricia Conrod, Hugh Garavan, Nelly Alia-Klein, Rita Z Goldstein

2020-08-28

Gray matter volume (GMV) in frontal cortical and limbic regions is susceptible to cocaine-associated reductions in cocaine-depende..

White matter abnormalities across different epilepsy syndromes in adults: an ENIGMA-Epilepsy study

Sean N Hatton, Khoa H Huynh, Leonardo Bonilha, Eugenio Abela, Saud Alhusaini, Andre Altmann, Marina KM Alvim, Akshara R Balachandra, Emanuele Bartolini, Benjamin Bender, Neda Bernasconi, Andrea Bernasconi, Boris Bernhardt, Nuria Bargallo, Benoit Caldairou, Maria E Caligiuri, Sarah JA Carr, Gianpiero L Cavalleri, Fernando Cendes, Luis Concha

2020-08-01

The epilepsies are commonly accompanied by widespread abnormalities in cerebral white matter. ENIGMA-Epilepsy is a large quantitat..

White matter disturbances in major depressive disorder: a coordinated analysis across 20 international cohorts in the ENIGMA MDD working group

Laura S van Velzen, Sinead Kelly, Dmitry Isaev, Andre Aleman, Lyubomir Aftanas, Jochen Bauer, Bernhard T Baune, Ivan Brak, Angela Carballedo, Colm G Connolly, Baptiste Couvy-Duchesne, Kathryn R Cullen, Konstantin Danilenko, Udo Dannlowski, Verena Enneking, Elena Filimonova, Katharina Foerster, Thomas Frodl, Ian H Gotlib, Nynke A Groenewold

2020-07-01

Alterations in white matter (WM) microstructure have been implicated in the pathophysiology of major depressive disorder (MDD). Ho..

ENIGMA MDD: seven years of global neuroimaging studies of major depression through worldwide data sharing

Lianne Schmaal, Elena Pozzi, Tiffany C Ho, Laura S van Velzen, Ilya M Veer, Nils Opel, Eus JW Van Someren, Laura KM Han, Lybomir Aftanas, Andre Aleman, Bernhard T Baune, Klaus Berger, Tessa F Blanken, Liliana Capitao, Baptiste Couvy-Duchesne, Kathryn R Cullen, Udo Dannlowski, Christopher Davey, Tracy Erwin-Grabner, Jennifer Evans

2020-05-29

A key objective in the field of translational psychiatry over the past few decades has been to identify the brain correlates of ma..

The ENIGMA-Epilepsy working group: Mapping disease from large data sets

Sanjay M Sisodiya, Christopher D Whelan, Sean N Hatton, Khoa Huynh, Andre Altmann, Mina Ryten, Annamaria Vezzani, Maria Eugenia Caligiuri, Angelo Labate, Antonio Gambardella, Victoria Ives-Deliperi, Stefano Meletti, Brent C Munsell, Leonardo Bonilha, Manuela Tondelli, Michael Rebsamen, Christian Rummel, Anna Elisabetta Vaudano, Roland Wiest, Akshara R Balachandra

2020-05-29

Epilepsy is a common and serious neurological disorder, with many different constituent conditions characterized by their electro ..

Brain structural abnormalities in obesity: relation to age, genetic risk, and common psychiatric disorders Evidence through univariate and multivariate mega-analysis including 6420 participants from the ENIGMA MDD working group

Nils Opel, Anbupalam Thalamuthu, Yuri Milaneschi, Dominik Grotegerd, Claas Flint, Ramona Leenings, Janik Goltermann, Maike Richter, Tim Hahn, Georg Woditsch, Klaus Berger, Marco Hermesdorf, Andrew McIntosh, Heather C Whalley, Mathew A Harris, Frank P MacMaster, Henrik Walter, Ilya M Veer, Thomas Frodl, Angela Carballedo

2020-05-28

Emerging evidence suggests that obesity impacts brain physiology at multiple levels. Here we aimed to clarify the relationship bet..

The ENIGMA Stroke Recovery Working Group: Big data neuroimaging to study brain-behavior relationships after stroke

Sook-Lei Liew, Artemis Zavaliangos-Petropulu, Neda Jahanshad, Catherine E Lang, Kathryn S Hayward, Keith R Lohse, Julia M Juliano, Francesca Assogna, Lee A Baugh, Anup K Bhattacharya, Bavrina Bigjahan, Michael R Borich, Lara A Boyd, Amy Brodtmann, Cathrin M Buetefisch, Winston D Byblow, Jessica M Cassidy, Adriana B Conforto, R Cameron Craddock, Michael A Dimyan

2020-04-20

The goal of the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) Stroke Recovery working group is to understand brai..

ENIGMA-DTI: Translating reproducible white matter deficits into personalized vulnerability metrics in cross-diagnostic psychiatric research

Peter Kochunov, L Elliot Hong, Emily L Dennis, Rajendra A Morey, David F Tate, Elisabeth A Wilde, Mark Logue, Sinead Kelly, Gary Donohoe, Pauline Favre, Josselin Houenou, Christopher RK Ching, Laurena Holleran, Ole A Andreassen, Laura S van Velzen, Lianne Schmaal, Julio E Villalon-Reina, Carrie E Bearden, Fabrizio Piras, Gianfranco Spalletta

2020-04-16

The ENIGMA-DTI (diffusion tensor imaging) workgroup supports analyses that examine the effects of psychiatric, neurological, and d..

Subcortical shape alterations in major depressive disorder: Findings from the ENIGMA major depressive disorder working group

Tiffany C Ho, Boris Gutman, Elena Pozzi, Hans J Grabe, Norbert Hosten, Katharina Wittfeld, Henry Voelzke, Bernhard Baune, Udo Dannlowski, Katharina Foerster, Dominik Grotegerd, Ronny Redlich, Andreas Jansen, Tilo Kircher, Axel Krug, Susanne Meinert, Igor Nenadic, Nils Opel, Richard Dinga, Dick J Veltman

2020-03-21

Alterations in regional subcortical brain volumes have been investigated as part of the efforts of an international consortium, EN..

ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries

Paul M Thompson, Neda Jahanshad, Christopher RK Ching, Lauren E Salminen, Sophia I Thomopoulos, Joanna Bright, Bernhard T Baune, Sara Bertolin, Janita Bralten, Willem B Bruin, Robin Buelow, Jian Chen, Yann Chye, Udo Dannlowski, Carolien GF de Kovel, Gary Donohoe, Lisa T Eyler, Stephen V Faraone, Pauline Favre, Courtney A Filippi

2020-03-20

This review summarizes the last decade of work by the ENIGMA (Enhancing NeuroImaging Genetics through Meta Analysis) Consortium, a..

The genetic architecture of the human cerebral cortex

Katrina L Grasby, Neda Jahanshad, Jodie N Painter, Lucia Colodro-Conde, Janita Bralten, Derrek P Hibar, Penelope A Lind, Fabrizio Pizzagalli, Christopher RK Ching, Mary Agnes B McMahon, Natalia Shatokhina, Leo CP Zsembik, Sophia I Thomopoulos, Alyssa H Zhu, Lachlan T Strike, Ingrid Agartz, Saud Alhusaini, Marcio AA Almeida, Dag Alnaes, Inge K Amlien

2020-03-20

The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influen..

An overview of the first 5 years of the ENIGMA obsessive-compulsive disorder working group: The power of worldwide collaboration

Odile A van den Heuvel, Premika SW Boedhoe, Sara Bertolin, Willem B Bruin, Clyde Francks, Iliyan Ivanov, Neda Jahanshad, Xiang-Zhen Kong, Jun S Kwon, Joseph O'Neill, Tomas Paus, Yash Patel, Fabrizio Piras, Lianne Schmaal, Carles Soriano-Mas, Gianfranco Spalletta, Guido A van Wingen, Je-Yeon Yun, Chris Vriend, H Blair Simpson

2020-03-10

Neuroimaging has played an important part in advancing our understanding of the neurobiology of obsessive-compulsive disorder (OCD..

Imaging suicidal thoughts and behaviors: a comprehensive review of 2 decades of neuroimaging studies

Lianne Schmaal, Anne-Laura van Harmelen, Vasiliki Chatzi, Elizabeth TC Lippard, Yara J Toenders, Lynnette A Averill, Carolyn M Mazure, Hilary P Blumberg

2020-02-01

Identifying brain alterations that contribute to suicidal thoughts and behaviors (STBs) are important to develop more targeted and..

Widespread white matter microstructural abnormalities in bipolar disorder: evidence from mega- and meta-analyses across 3033 individuals

Pauline Favre, Melissa Pauling, Jacques Stout, Franz Hozer, Samuel Sarrazin, Christoph Abe, Martin Alda, Clara Alloza, Silvia Alonso-Lana, Ole A Andreassen, Bernhard T Baune, Francesco Benedetti, Geraldo F Busatto, Erick J Canales-Rodriguez, Xavier Caseras, Tiffany Moukbel Chaim-Avancini, Christopher RK Ching, Udo Dannlowski, Michael Deppe, Lisa T Eyler

2019-12-01

Fronto-limbic white matter (WM) abnormalities are assumed to lie at the heart of the pathophysiology of bipolar disorder (BD); how..

Genetic architecture of subcortical brain structures in 38,851 individuals

Claudia L Satizabal, Hieab HH Adams, Derrek P Hibar, Charles C White, Maria J Knol, Jason L Stein, Markus Scholz, Muralidharan Sargurupremraj, Neda Jahanshad, Gennady Roshchupkin, Albert Smith, Joshua C Bis, Xueqiu Jian, Michelle Luciano, Edith Hofer, Alexander Teumer, Sven J van der Lee, Jingyun Yang, Lisa R Yanek, Tom Lee

2019-11-01

Subcortical brain structures are integral to motion, consciousness, emotions and learning. We identified common genetic variation ..

ENIGMA MDD: Seven Years of Global Neuroimaging Studies of Major Depression through Worldwide Data Sharing

Lianne Schmaal, Elena Pozzi, Tiffany Ho, Laura S van Velzen, Ilya Veer, Nils Opel, Eus Van Someren, Laura KM Han, Lybomir Aftanas, Andre Aleman, Bernhard T Baune, Klaus Berger, Tessa Blanken, Liliana Capitao, Baptiste Couvy-Duchesne, Kathryn R Cullen, Udo Dannlowski, Christopher Davey, Tracy Erwin-Grabner, Jennifer Evans

2019-10-14

<p>A key objective in the field of translational psychiatry over the past few decades has been to identify the brain correlates co..

Neuroimaging predictors of onset and course of depression in childhood and adolescence: A systematic review of longitudinal studies

Yara J Toenders, Laura S van Velzen, Ivonne Z Heideman, Ben J Harrison, Christopher G Davey, Lianne Schmaal

2019-10-01

Major depressive disorder (MDD) often emerges during adolescence with detrimental effects on development as well as lifetime conse..

Journal of Affective Disorders Special Issue on Suicide-Related Research: Hopeful progress but much research urgently needed

A-L Van Harmelen, L Schmaal, HP Blumberg

2019-05-15

Mega-Analysis of Gray Matter Volume in Substance Dependence: General and Substance-Specific Regional Effects

Scott Mackey, Nicholas Allgaier, Bader Chaarani, Philip Spechler, Catherine Orr, Janice Bunn, Nicholas B Allen, Nelly Alia-Klein, Albert Batalla, Sara Blaine, Samantha Brooks, Elisabeth Caparelli, Yann Ying Chye, Janna Cousijn, Alain Dagher, Sylvane Desrivieres, Sarah Feldstein-Ewing, John J Foxe, Rita Z Goldstein, Anna E Goudriaan

2019-02-01

OBJECTIVE: Although lower brain volume has been routinely observed in individuals with substance dependence compared with nondepen..

An Empirical Comparison of Meta- and Mega-Analysis With Data From the ENIGMA Obsessive-Compulsive Disorder Working Group

Premika SW Boedhoe, Martijn W Heymans, Lianne Schmaal, Yoshinari Abe, Pino Alonso, Stephanie H Ameis, Alan Anticevic, Paul D Arnold, Marcelo C Batistuzzo, Francesco Benedetti, Jan C Beucke, Irene Bollettini, Anushree Bose, Silvia Brem, Anna Calvo, Rosa Calvo, Yuqi Cheng, Kang lk K Cho, Valentina Ciullo, Sara Dallaspezia

2019-01-08

Objective: Brain imaging communities focusing on different diseases have increasingly started to collaborate and to pool data to p..

Subcortical brain structure and suicidal behaviour in major depressive disorder: a meta-analysis from the ENIGMA-MDD working group

ME Renteria, L Schmaal, DP Hibar, B Couvy-Duchesne, LT Strike, NT Mills, GI de Zubicaray, KL McMahon, SE Medland, NA Gillespie, SN Hatton, J Lagopoulos, DJ Veltman, N van der Wee, TGM van Erp, K Wittfeld, HJ Grabe, A Block, K Hegenscheid, H Voelzke

2017-05-02

The aetiology of suicidal behaviour is complex, and knowledge about its neurobiological mechanisms is limited. Neuroimaging method..