TARGETING MUC13 TO SENSITISE COLORECTAL CANCER TO THERAPY

Grant number: 1164141 | Funding period: 2019 - 2021

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Abstract

We have found that a naturally occurring mucin molecule, called MUC13, protects the cells lining the bowel wall from death under stress. Colon cancer cells retain MUC13 and use it to protect them from chemotherapy, biological therapy and immunotherapy. In this project we aim to further understand the cellular mechanisms underlying MUC13’s action and focus on capitalising on this knowledge to develop new therapies for colon cancer.

University of Melbourne Researchers