Transplantation of Pig Islets to Treat Type 1 Diabetes

Grant number: 1156889 | Funding period: 2019 - 2023

Completed

Abstract

Type 1 diabetes (T1D) destroys the insulin-producing cells within the islets of the pancreas, causing blood sugar to rise. Transplantation is the only way to restore normal blood sugar control, but there will never be enough human donors to meet demand. We are pursuing an alternative approach using islets from pigs, which will work well in humans if we can prevent them from being rejected.

Related publications (4)

Characterisation of transgenic pigs expressing a human T cell-depleting anti-CD2 monoclonal antibody

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2024-01-01

Background: Pig islet xenotransplantation is a potential treatment for type 1 diabetes. We have shown that maintenance immunosuppr..

Evaluation of expression of a human T-cell depleting monoclonal antibody in islets and other tissues of transgenic pigs

Evelyn Salvaris, Nella Fisicaro, Stephen Mcilfatrick, Adwin Thomas, Erin Fuller, Andrew M Lew, Mark B Nottle, Wayne J Hawthorne, Peter J Cowan

2023-10-01

Xenotransplantation of Genetically Modified Neonatal Pig Islets Cures Diabetes in Baboons

WJ Hawthorne, EJ Salvaris, YV Chew, H Burns, J Hawkes, H Barlow, M Hu, AM Lew, MB Nottle, PJ O’Connell, PJ Cowan

2022-06-16

Xenotransplantation using porcine donors is rapidly approaching clinical applicability as an alternative therapy for treatment of ..

CHARACTERIZATION OF TRANSGENIC PIGS EXPRESSING AN ANTI-CD2 MONOCLONAL ANTIBODY. A CONTINUING QUEST FOR THE IDEAL ISLET DONOR

Evelyn Salvaris, Adwin Thomas, Nicole Byrne, Nella Fisicaro, Mark B Nottle, Wayne J Hawthorne, Peter J Cowan

2021-09-01

University of Melbourne Researchers

Peter Cowan