RESPIRATORY MODULATION: ROLE IN THE DEVELOPMENT OF CARDIOVASCULAR DISEASES

Grant number: 1156727 | Funding period: 2019 - 2021

Completed

Abstract

The body's regulation of breathing and cardiovascular function needs to be matched to maintain optimal functioning of the organism. The brain plays an important role in this regulation. Problems with this interaction play important roles in the development or maintenance of some cardiovascular diseases such as hypertension or heart failure. This grant aims to identify the important neural circuits in order to understand how this interaction is altered in disease states.

Related publications (4)

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Analysis of the distribution of vagal afferent projections from different peripheral organs to the nucleus of the solitary tract in rats

Jaspreet K Bassi, Angela A Connelly, Andrew G Butler, Yehe Liu, Anahita Ghanbari, David GS Farmer, Michael W Jenkins, Mariana R Melo, Stuart J McDougall, Andrew M Allen

2022-08-21

Anatomical tracing studies examining the vagal system can conflate details of sensory afferent and motor efferent neurons. Here, w..

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Advancing respiratory-cardiovascular physiology with the working heart-brainstem preparation over 25 years

Julian FR Paton, Benedito H Machado, Davi JA Moraes, Daniel B Zoccal, Ana P Abdala, Jeffrey C Smith, Vagner R Antunes, David Murphy, Mathias Dutschmann, Rishi R Dhingra, Robin McAllen, Anthony E Pickering, Richard JA Wilson, Trevor A Day, Nicole O Barioni, Andrew M Allen, Clement Menuet, Joseph Donnelly, Igor Felippe, Walter M St-John

2022-04-07

Twenty-five years ago, a new physiological preparation called the working heart-brainstem preparation (WHBP) was introduced with t..

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A Chemogenetic Tool that Enables Functional Neural Circuit Analysis

Hoai Buu Ngo, Mariana R Melo, Sharon Layfield, Angela A Connelly, Jaspreet K Bassi, Lin Xie, Clement Menuet, Stuart J McDougall, Ross AD Bathgate, Andrew M Allen

2020-09-15

Chemogenetics enables manipulation of neuronal activity in experimental animals. While providing information about the transduced ..

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PreBotzinger complex neurons drive respiratory modulation of blood pressure and heart rate

Clement Menuet, Angela A Connelly, Jaspreet K Bassi, Mariana R Melo, Sheng Le, Jessica Kamar, Natasha N Kumar, Stuart J McDougall, Simon McMullan, Andrew M Allen

2020-06-15

Heart rate and blood pressure oscillate in phase with respiratory activity. A component of these oscillations is generated central..

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