Regulation of Glycemic Control by Secreted Modular Calcium-Binding Protein 1

Grant number: 1156508 | Funding period: 2019 - 2021

Completed

Abstract

The major problem for type 2 diabetes patients is an inability to control their blood glucose levels, and high blood glucose levels cause the life-threatening complications associated with this disease. We have recently discovered a protein that reduces blood glucose levels. The aim of this project is to determine the long-term effectiveness of this protein and to develop more active forms of the protein. This will improve the management of diabetes.

Related publications (8)

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Diabetic heart shows preferential secretion of inner mitochondrial membrane proteins in the presence of mitochondrial oxidative stress

PM Miotto, J Bayliss, G Fidelito, JR Bell, LMD Delbridge, MJ Watt, MK Montgomery

2025-12-01

Heart disease, including diabetic cardiomyopathy, is a leading cause of mortality in patients with type 2 diabetes (T2D). Defects ..

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Exercise training induces depot-specific remodeling of protein secretion in skeletal muscle and adipose tissue of obese male mice

MK Montgomery, W De Nardo, MJ Watt

2023-09-01

Acute exercise induces changes in circulating proteins, which are known to alter metabolism and systemic energy balance. Skeletal ..

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Investigating dual inhibition of ACC and CD36 for the treatment of nonalcoholic fatty liver disease in mice

CJ Devereux, J Bayliss, SN Keenan, MK Montgomery, MJ Watt

2023-02-01

Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide. Dysregulation in hepatic lipid metabo..

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Proteomic analysis reveals exercise training induced remodelling of hepatokine secretion and uncovers syndecan-4 as a regulator of hepatic lipid metabolism

W De Nardo, PM Miotto, J Bayliss, S Nie, SN Keenan, MK Montgomery, MJ Watt

2022-06-01

Objective: Non-alcoholic fatty liver disease (NAFLD) is linked to impaired lipid metabolism and systemic insulin resistance, which..

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Hexosaminidase A (HEXA) regulates hepatic sphingolipid and lipoprotein metabolism in mice

MK Montgomery, AZ Taddese, J Bayliss, S Nie, NA Williamson, MJ Watt

2021-12-01

Hexosaminidase A (HexA), a heterodimer consisting of HEXA and HEXB, converts the ganglioside sphingolipid GM2 to GM3 by removing a..

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GIP receptor deletion in mice confers resistance to high-fat diet-induced obesity via alterations in energy expenditure and adipose tissue lipid metabolism

GA Boer, SN Keenan, PM Miotto, JJ Holst, MJ Watt

2021-01-01

Glucose-dependent insulinotropic polypeptide (GIP) is best known as an incretin hormone that is secreted from K-cells of the proxi..

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SMOC1 is a glucose-responsive hepatokine and therapeutic target for glycemic control

MK Montgomery, J Bayliss, C Devereux, A Bezawork-Geleta, D Roberts, C Huang, RB Schittenhelm, A Ryan, SL Townley, LA Selth, TJ Biden, GR Steinberg, D Samocha-Bonet, RCR Meex, MJ Watt

2020-01-01

Intertissue communication is a fundamental feature of metabolic regulation, and the liver is central to this process. We have iden..

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The Liver as an Endocrine Organ - Linking NAFLD and Insulin Resistance

MJ Watt, PM Miotto, W De Nardo, MK Montgomery

2019-05-10

The liver is a dynamic organ that plays critical roles in many physiological processes, including the regulation of systemic gluco..

University of Melbourne Researchers