FUNCTIONAL AND MOLECULAR STUDIES OF AN INTERACTION BETWEEN THE ANTIGEN-PRESENTING MOLECULE MR1 AND LILR IMMUNE REGULATORY RECEPTORS
Grant number: 1165467 | Funding period: 2019 - 2021
Our body’s defense against invading pathogens relies on our immune system. The immune system is made up of multiple cell types that each performs different tasks. In order to function correctly, a family of molecules called inhibitory receptors regulates the immune response. This project will characterize a novel inhibitory receptor axis that we have recently discovered in humans. This may open up new avenues of cancer therapy and autoimmune therapy in the future.
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Gamma delta (γδ) T cells are essential to protective immunity. In humans, most γδ T cells express Vγ9Vδ2+ T cell receptors (TCRs) ..