REGULATION OF STAGE DIFFERENTIATION IN APICOMPLEXAN PARASITES BY ALTERNATIVE SPLICING

Grant number: 1165354 | Funding period: 2019 - 2023

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Abstract

Multicellular organisms possess different specialised cells with different gene products in different cell types. Much of this specialisation is due to alternative processing (splicing) of gene transcripts. We have recently described the same phenomenon in unicellular parasites. We will now test how alternative splicing drives cellular differentiation to generate specialised parasite forms that infect mosquito vectors, and forms that cause latent, untreatable infections.

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University of Melbourne Researchers

Stuart Ralph Biochemistry and Pharmacology

Geoffrey McFadden Biosciences

Dean Goodman Biosciences