Understanding And Exploiting How Different Cell Death Pathways Control Intracellular Infections

Abstract

Tuberculosis, typhoid fever and influenza continue to kill millions of people. These infections are caused by pathogens that hide from the immune system inside host cells. Our studies examine the mechanisms that allow the immune system to evict these pathogens from cellular 'hide-out'. This project will advance our basic understanding of the immune system and will identify targets for novel therapies that are desperately needed in fights against these global killers.