UNDERSTANDING AND EXPLOITING HOW DIFFERENT CELL DEATH PATHWAYS CONTROL INTRACELLULAR INFECTIONS
Grant number: 1159658 | Funding period: 2019 - 2022
Tuberculosis, typhoid fever and influenza continue to kill millions of people. These infections are caused by pathogens that hide from the immune system inside host cells. Our studies examine the mechanisms that allow the immune system to evict these pathogens from cellular 'hide-out'. This project will advance our basic understanding of the immune system and will identify targets for novel therapies that are desperately needed in fights against these global killers.
Related publications (9)
Ptpn2 and KLRG1 regulate the generation and in skin
Katharina Hochheiser, Florian Wiede, Teagan Wagner, David Freestone, Matthias H Enders, Moshe Olshansky, Brendan Russ, Simone Nussing, Emma Bawden, Asolina Braun, Annabell Bachem, Elise Gressier, Robyn McConville, Simone L Park, Claerwen M Jones, Gayle M Davey, David E Gyorki, David Tscharke, Ian A Parish, Stephen Turner
Tissue-resident memory T cells (TRM cells) are key elements of tissue immunity. Here, we investigated the role of the regulator of..
Critical cancer vulnerabilities identified by unbiased CRISPR/Cas9 screens inform on efficient cancer Immunotherapy
Margaret A Potts, Jackson A McDonald, Kate D Sutherland, Marco J Herold
The mutational landscape of human cancers is highly complex. While next generation sequencing aims to comprehensively catalogue so..
Flexible Usage and Interconnectivity of Diverse Cell Death Pathways Protect against Intracellular Infection
Marcel Doerflinger, Yexuan Deng, Paul Whitney, Ranja Salvamoser, Sven Engel, Andrew J Kueh, Lin Tai, Annabell Bachem, Elise Gressier, Niall D Geoghegan, Stephen Wilcox, Kelly L Rogers, Alexandra L Garnham, Michael A Dengler, Stefanie M Bader, Gregor Ebert, Jaclyn S Pearson, Dominic De Nardo, Nancy Wang, Chenying Yang
Programmed cell death contributes to host defense against pathogens. To investigate the relative importance of pyroptosis, necropt..
Targeting platelets for improved outcome in KRAS-driven lung adenocarcinoma
Stephanie R Hyslop, Marliese Alexander, Alesha A Thai, Ariena Kersbergen, Andrew J Kueh, Marco J Herold, Jason Corbin, Pradnya Gangatirkar, Ashley P Ng, Benjamin J Solomon, Warren S Alexander, Kate D Sutherland, Emma C Josefsson
Elevated platelet count is associated with poor survival in certain solid cancers, including lung cancer. In addition, experimenta..
An Erg-driven transcriptional program controls B cell lymphopoiesis.
Ashley P Ng, Hannah D Coughlan, Soroor Hediyeh-Zadeh, Kira Behrens, Timothy M Johanson, Michael Sze Yuan Low, Charles C Bell, Omer Gilan, Yih-Chih Chan, Andrew J Kueh, Thomas Boudier, Rebecca Feltham, Anna Gabrielyan, Ladina DiRago, Craig D Hyland, Helen Ierino, Sandra Mifsud, Elizabeth Viney, Tracy Willson, Mark A Dawson
B lymphoid development is initiated by the differentiation of hematopoietic stem cells into lineage committed progenitors, ultimat..