UNDERSTANDING AND EXPLOITING HOW DIFFERENT CELL DEATH PATHWAYS CONTROL INTRACELLULAR INFECTIONS

Ptpn2 and KLRG1 regulate the generation and in skin

Katharina Hochheiser, Florian Wiede, Teagan Wagner, David Freestone, Matthias H Enders, Moshe Olshansky, Brendan Russ, Simone Nussing, Emma Bawden, Asolina Braun, Annabell Bachem, Elise Gressier, Robyn McConville, Simone L Park, Claerwen M Jones, Gayle M Davey, David E Gyorki, David Tscharke, Ian A Parish, Stephen Turner

2021-06-07

Tissue-resident memory T cells (TRM cells) are key elements of tissue immunity. Here, we investigated the role of the regulator of..

Intracellular Staphylococcus aureus and host cell death pathways

Ye Mon Soe, Sammy Bedoui, Timothy P Stinear, Abderrahman Hachani

2021-02-24

Staphylococcus aureus is a major opportunistic human pathogen that is globally prevalent. Although S. aureus and humans may have c..

CRISPR base editing applications for identifying cancer-driving mutations

Martin Pal, Marco J Herold

2021-02-01

CRISPR base editing technology is a promising genome editing tool as (i) it does not require a DNA template to introduce mutations..

Critical cancer vulnerabilities identified by unbiased CRISPR/Cas9 screens inform on efficient cancer Immunotherapy

Margaret A Potts, Jackson A McDonald, Kate D Sutherland, Marco J Herold

2020-12-01

The mutational landscape of human cancers is highly complex. While next generation sequencing aims to comprehensively catalogue so..

Flexible Usage and Interconnectivity of Diverse Cell Death Pathways Protect against Intracellular Infection

Marcel Doerflinger, Yexuan Deng, Paul Whitney, Ranja Salvamoser, Sven Engel, Andrew J Kueh, Lin Tai, Annabell Bachem, Elise Gressier, Niall D Geoghegan, Stephen Wilcox, Kelly L Rogers, Alexandra L Garnham, Michael A Dengler, Stefanie M Bader, Gregor Ebert, Jaclyn S Pearson, Dominic De Nardo, Nancy Wang, Chenying Yang

2020-09-15

Programmed cell death contributes to host defense against pathogens. To investigate the relative importance of pyroptosis, necropt..

Emerging connectivity of programmed cell death pathways and its physiological implications

Sammy Bedoui, Marco J Herold, Andreas Strasser

2020-09-01

The removal of functionally dispensable, infected or potentially neoplastic cells is driven by programmed cell death (PCD) pathway..

Targeting platelets for improved outcome in KRAS-driven lung adenocarcinoma

Stephanie R Hyslop, Marliese Alexander, Alesha A Thai, Ariena Kersbergen, Andrew J Kueh, Marco J Herold, Jason Corbin, Pradnya Gangatirkar, Ashley P Ng, Benjamin J Solomon, Warren S Alexander, Kate D Sutherland, Emma C Josefsson

2020-07-16

Elevated platelet count is associated with poor survival in certain solid cancers, including lung cancer. In addition, experimenta..

The pro-survival Bcl-2 family member A1 delays spontaneous and FAS ligand-induced apoptosis of activated neutrophils

Robyn L Schenk, Lahiru Gangoda, Kate E Lawlor, Lorraine A O'Reilly, Andreas Strasser, Marco J Herold

2020-06-18

An Erg-driven transcriptional program controls B cell lymphopoiesis.

Ashley P Ng, Hannah D Coughlan, Soroor Hediyeh-Zadeh, Kira Behrens, Timothy M Johanson, Michael Sze Yuan Low, Charles C Bell, Omer Gilan, Yih-Chih Chan, Andrew J Kueh, Thomas Boudier, Rebecca Feltham, Anna Gabrielyan, Ladina DiRago, Craig D Hyland, Helen Ierino, Sandra Mifsud, Elizabeth Viney, Tracy Willson, Mark A Dawson

2020-06-15

B lymphoid development is initiated by the differentiation of hematopoietic stem cells into lineage committed progenitors, ultimat..