UNDERSTANDING AND EXPLOITING HOW DIFFERENT CELL DEATH PATHWAYS CONTROL INTRACELLULAR INFECTIONS

Grant number: 1159658 | Funding period: 2019 - 2022

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Abstract

Tuberculosis, typhoid fever and influenza continue to kill millions of people. These infections are caused by pathogens that hide from the immune system inside host cells. Our studies examine the mechanisms that allow the immune system to evict these pathogens from cellular 'hide-out'. This project will advance our basic understanding of the immune system and will identify targets for novel therapies that are desperately needed in fights against these global killers.

Related publications (2)

Flexible Usage and Interconnectivity of Diverse Cell Death Pathways Protect against Intracellular Infection

Marcel Doerflinger, Yexuan Deng, Paul Whitney, Ranja Salvamoser, Sven Engel, Andrew J Kueh, Lin Tai, Annabell Bachem, Elise Gressier, Niall D Geoghegan, Stephen Wilcox, Kelly L Rogers, Alexandra L Garnham, Michael A Dengler, Stefanie M Bader, Gregor Ebert, Jaclyn S Pearson, Dominic De Nardo, Nancy Wang, Chenying Yang

2020-09-15

Programmed cell death contributes to host defense against pathogens. To investigate the relative importance of pyroptosis, necropt..

Targeting platelets for improved outcome in KRAS-driven lung adenocarcinoma

Stephanie R Hyslop, Marliese Alexander, Alesha A Thai, Ariena Kersbergen, Andrew J Kueh, Marco J Herold, Jason Corbin, Pradnya Gangatirkar, Ashley P Ng, Benjamin J Solomon, Warren S Alexander, Kate D Sutherland, Emma C Josefsson

2020-07-16

Elevated platelet count is associated with poor survival in certain solid cancers, including lung cancer. In addition, experimenta..