FROM THE STONE AGE TO THE STATE OF THE ART – MULTIDIMENSIONAL PRECISION MEDICINE FOR PERITONEAL CRC
Grant number: 1156391 | Funding period: 2019 - 2023
Peritoneal cancer develops in the abdomen and may be present at primary diagnosis but can also arise from tumour cells that remain post-surgery or indeed they are mobilized by surgery. It is extremely difficult and expensive to treat and is rapidly fatal compared to most other cancers. We will use genetics, immunology assays, pre-clinical models with national and international collaborations to reduce, treat and cure peritoneal cancer and will test whether we can change clinical practice.
Related publications (5)
Effect of Surgical Humidification on Inflammation and Peritoneal Trauma in Colorectal Cancer Surgery: A Randomized Controlled Trial
Shienny Sampurno, Timothy Chittleborough, Meara Dean, Michael Flood, Sandra Carpinteri, Sara Roth, Rosemary M Millen, Helen Cain, Joseph CH Kong, John MacKay, Satish K Warrier, Jacob McCormick, Jonathon G Hiller, Alexander G Heriot, Robert G Ramsay, Andrew C Lynch
BACKGROUND: Pre-clinical studies indicate that dry-cold-carbon-dioxide (DC-CO2) insufflation leads to more peritoneal damage, infl..
Organoids as a Robust Preclinical Model for Precision Medicine in Colorectal Cancer: A Systematic Review
Michael Flood, Vignesh Narasimhan, Kasmira Wilson, Wei Mou Lim, Robert Ramsay, Michael Michael, Alexander Heriot
BACKGROUND: Patients with locally advanced or metastatic colorectal cancer (CRC) display heterogeneous responses to standard-of-ca..
Medium-throughput Drug Screening of Patient-derived Organoids from Colorectal Peritoneal Metastases to Direct Personalized Therapy
Vignesh Narasimhan, Josephine A Wright, Michael Churchill, Tongtong Wang, Rachele Rosati, Tamsin RM Lannagan, Laura Vrbanac, Anne B Richardson, Hiroki Kobayashi, Timothy Price, Gayle XY Tye, Julie Marker, Peter J Hewett, Michael P Flood, Shalini Pereira, G Adam Whitney, Michael Michael, Jeanne Tie, Siddhartha Mukherjee, Carla Grandori
PURPOSE: Patients with colorectal cancer with peritoneal metastases (CRPMs) have limited treatment options and the lowest colorect..