FROM THE STONE AGE TO THE STATE OF THE ART – MULTIDIMENSIONAL PRECISION MEDICINE FOR PERITONEAL CRC

Organoids as a Robust Preclinical Model for Precision Medicine in Colorectal Cancer: A Systematic Review

Michael Flood, Vignesh Narasimhan, Kasmira Wilson, Wei Mou Lim, Robert Ramsay, Michael Michael, Alexander Heriot

2021-10-01

BACKGROUND: Patients with locally advanced or metastatic colorectal cancer (CRC) display heterogeneous responses to standard-of-ca..

Medium-throughput Drug Screening of Patient-derived Organoids from Colorectal Peritoneal Metastases to Direct Personalized Therapy

Vignesh Narasimhan, Josephine A Wright, Michael Churchill, Tongtong Wang, Rachele Rosati, Tamsin RM Lannagan, Laura Vrbanac, Anne B Richardson, Hiroki Kobayashi, Timothy Price, Gayle XY Tye, Julie Marker, Peter J Hewett, Michael P Flood, Shalini Pereira, G Adam Whitney, Michael Michael, Jeanne Tie, Siddhartha Mukherjee, Carla Grandori

2020-07-15

PURPOSE: Patients with colorectal cancer with peritoneal metastases (CRPMs) have limited treatment options and the lowest colorect..