RATIONAL DESIGN OF NOVEL VACCINES FOR THE CONTROL OF INFLUENZA B
Grant number: 1162760 | Funding period: 2019 - 2023
Current influenza vaccines elicit poor protection against viruses undergoing rapid change. We will define the conserved sites of vulnerability on the hemagglutinin of influenza B viruses and use this information to develop and assess novel influenza vaccine concepts in animal models of human influenza infection.
Related publications (17)
SARS-CoV-2-specific T cell memory with common TCR alpha beta motifs is established in unvaccinated children who seroconvert after infection
Louise C Rowntree, Thi HO Nguyen, Lukasz Kedzierski, Melanie R Neeland, Jan Petersen, Jeremy Chase Crawford, Lilith F Allen, E Bridie Clemens, Brendon Chua, Hayley A McQuilten, Anastasia A Minervina, Mikhail Pogorelyy, Priyanka Chaurasia, Hyon-Xhi Tan, Adam K Wheatley, Xiaoxiao Jia, Fatima Amanat, Florian Krammer, E Kaitlynn Allen, Sabrina Sonda
As the establishment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific T cell memory in children remains la..
The magnitude and timing of recalled immunity after breakthrough infection is shaped by SARS-CoV-2 variants
Marios Koutsakos, Wen Shi Lee, Arnold Reynaldi, Hyon-Xhi Tan, Grace Gare, Paul Kinsella, Kwee Chin Liew, George Taiaroa, Deborah A Williamson, Helen E Kent, Eva Stadler, Deborah Cromer, David S Khoury, Adam K Wheatley, Jennifer A Juno, Miles P Davenport, Stephen J Kent
Vaccination against SARS-CoV-2 protects from infection and improves clinical outcomes in breakthrough infections, likely reflectin..
Cutting Edge: SARS-CoV-2 Infection Induces Robust Germinal Center Activity in the Human Tonsil
Hyon-Xhi Tan, Kathleen M Wragg, Hannah G Kelly, Robyn Esterbauer, Benjamin J Dixon, Jillian SY Lau, Katie L Flanagan, Carolien E van de Sandt, Katherine Kedzierska, James H McMahon, Adam K Wheatley, Jennifer A Juno, Stephen J Kent
Understanding the generation of immunity to SARS-CoV-2 in lymphoid tissues draining the site of infection has implications for imm..
Lung-resident memory B cells established after pulmonary influenza infection display distinct transcriptional and phenotypic profiles
Hyon-Xhi Tan, Jennifer A Juno, Robyn Esterbauer, Hannah G Kelly, Kathleen M Wragg, Penny Konstandopoulos, Sheilajen Alcantara, Carolina Alvarado, Robert Jones, Graham Starkey, Boa Zhong Wang, Osamu Yoshino, Thomas Tiang, M Lindsay Grayson, Helen Opdam, Rohit D'Costa, Angela Vago, Laura K Mackay, Claire L Gordon, David Masopust
Recent studies have established that memory B cells, largely thought to be circulatory in the blood, can take up long-term residen..
Robust and prototypical immune responses toward influenza vaccines in the high-risk group of Indigenous Australians
Luca Hensen, Thi HO Nguyen, Louise C Rowntree, Timon Damelang, Marios Koutsakos, Malet Aban, Aeron Hurt, Kim L Harland, Maria Auladell, Carolien E van de Sandt, Anngie Everitt, Cath Blacker, Damian A Oyong, Jessica R Loughland, Jessica R Webb, Bruce D Wines, P Mark Hogarth, Katie L Flanagan, Magdalena Plebanski, Adam Wheatley
Morbidity and mortality rates from seasonal and pandemic influenza occur disproportionately in high-risk groups, including Indigen..
SARS-CoV-2-specific CD8( ) T-cell responses and TCR signatures in the context of a prominent HLA-A*24:02 allomorph
Louise C Rowntree, Jan Petersen, Jennifer A Juno, Priyanka Chaurasia, Kathleen Wragg, Marios Koutsakos, Luca Hensen, Adam K Wheatley, Stephen J Kent, Jamie Rossjohn, Katherine Kedzierska, Thi HO Nguyen
In-depth understanding of human T-cell-mediated immunity in coronavirus disease 2019 (COVID-19) is needed if we are to optimize va..
Decay of Fc-dependent antibody functions after mild to moderate COVID-19
Wen Shi Lee, Kevin John Selva, Samantha K Davis, Bruce D Wines, Arnold Reynaldi, Robyn Esterbauer, Hannah G Kelly, Ebene R Haycroft, Hyon-Xhi Tan, Jennifer A Juno, Adam K Wheatley, P Mark Hogarth, Deborah Cromer, Miles P Davenport, Amy W Chung, Stephen J Kent
The capacity of antibodies to engage with immune cells via the Fc region is important in preventing and controlling many infectiou..
CD8( ) T cells specific for an immunodominant SARS-CoV-2 nucleocapsid epitope display high naive precursor frequency and TCR promiscuity
Thi HO Nguyen, Louise C Rowntree, Jan Petersen, Brendon Y Chua, Luca Hensen, Lukasz Kedzierski, Carolien E van de Sandt, Priyanka Chaurasia, Hyon-Xhi Tan, Jennifer R Habel, Wuji Zhang, Lilith F Allen, Linda Earnest, Kai Yan Mak, Jennifer A Juno, Kathleen Wragg, Francesca L Mordant, Fatima Amanat, Florian Krammer, Nicole A Mifsud
To better understand primary and recall T cell responses during coronavirus disease 2019 (COVID-19), it is important to examine un..
Prospects for durable immune control of SARS-CoV-2 and prevention of reinfection
Deborah Cromer, Jennifer A Juno, David Khoury, Arnold Reynaldi, Adam K Wheatley, Stephen J Kent, Miles P Davenport
Immunity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is central to long-term control of the current ..
Integrated immune dynamics define correlates of COVID-19 severity and antibody responses
Marios Koutsakos, Louise C Rowntree, Luca Hensen, Brendon Y Chua, Carolien E van de Sandt, Jennifer R Habel, Wuji Zhang, Xiaoxiao Jia, Lukasz Kedzierski, Thomas M Ashhurst, Givanna H Putri, Felix Marsh-Wakefield, Mark N Read, Davis N Edwards, E Bridie Clemens, Chinn Yi Wong, Francesca L Mordant, Jennifer A Juno, Fatima Amanat, Jennifer Audsley
SARS-CoV-2 causes a spectrum of COVID-19 disease, the immunological basis of which remains ill defined. We analyzed 85 SARS-CoV-2-..
Immunogenicity of prime-boost protein subunit vaccine strategies against SARS-CoV-2 in mice and macaques
Tan Hyon-Xhi, Jennifer A Juno, Wen Shi Lee, Isaac Barber-Axthelm, Hannah G Kelly, Kathleen M Wragg, Robyn Esterbauer, Thakshila Amarasena, Francesca L Mordant, Kanta Subbarao, Stephen J Kent, Adam K Wheatley
SARS-CoV-2 vaccines are advancing into human clinical trials, with emphasis on eliciting high titres of neutralising antibodies ag..
Evolution of immune responses to SARS-CoV-2 in mild-moderate COVID-19
Adam K Wheatley, Jennifer A Juno, Jing J Wang, Kevin J Selva, Arnold Reynaldi, Hyon-Xhi Tan, Wen Shi Lee, Kathleen M Wragg, Hannah G Kelly, Robyn Esterbauer, Samantha K Davis, Helen E Kent, Francesca L Mordant, Timothy E Schlub, David L Gordon, David S Khoury, Kanta Subbarao, Deborah Cromer, Tom P Gordon, Amy W Chung
The durability of infection-induced SARS-CoV-2 immunity has major implications for reinfection and vaccine development. Here, we s..
Suboptimal SARS-CoV-2-specific CD8( ) T cell response associated with the prominent HLA-A*02:01 phenotype
Jennifer R Habel, Thi HO Nguyen, Carolien E van de Sandt, Jennifer A Juno, Priyanka Chaurasia, Kathleen Wragg, Marios Koutsakos, Luca Hensen, Xiaoxiao Jia, Brendon Chua, Wuji Zhang, Hyon-Xhi Tan, Katie L Flanagan, Denise L Doolan, Joseph Torresi, Weisan Chen, Linda M Wakim, Allen C Cheng, Peter C Doherty, Jan Petersen
An improved understanding of human T cell-mediated immunity in COVID-19 is important for optimizing therapeutic and vaccine strate..
Humoral and circulating follicular helper T cell responses in recovered patients with COVID-19
Jennifer A Juno, Hyon-Xhi Tan, Wen Shi Lee, Arnold Reynaldi, Hannah G Kelly, Kathleen Wragg, Robyn Esterbauer, Helen E Kent, C Jane Batten, Francesca L Mordant, Nicholas A Gherardin, Phillip Pymm, Melanie H Dietrich, Nichollas E Scott, Wai-Hong Tham, Dale Godfrey, Kanta Subbarao, Miles P Davenport, Stephen J Kent, Adam K Wheatley
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has dramatically expedited global vaccine development ef..
Self-assembling influenza nanoparticle vaccines drive extended germinal center activity and memory B cell maturation.
Hannah G Kelly, Hyon-Xhi Tan, Jennifer A Juno, Robyn Esterbauer, Yi Ju, Wenbo Jiang, Verena C Wimmer, Brigette C Duckworth, Joanna R Groom, Frank Caruso, Masaru Kanekiyo, Stephen J Kent, Adam K Wheatley
Protein-based, self-assembling nanoparticles elicit superior immunity compared with soluble protein vaccines, but the immune mecha..