Rational Design of Novel Vaccines for the Control of Influenza B

Mucosal vaccination against SARS-CoV-2 using recombinant influenza viruses delivering self-assembling nanoparticles

D Pilapitiya, WS Lee, MN Vu, A Kelly, RH Webster, M Koutsakos, SJ Kent, JA Juno, HX Tan, AK Wheatley

2025-02-06

Recombinant influenza viruses are promising vectors that can bolster antibody and resident lymphocyte responses within mucosal sit..

Durable reprogramming of neutralizing antibody responses following Omicron breakthrough infection

WS Lee, HX Tan, A Reynaldi, R Esterbauer, M Koutsakos, J Nguyen, T Amarasena, HE Kent, A Aggarwal, SG Turville, G Taiaroa, P Kinsella, KC Liew, T Tran, DA Williamson, D Cromer, MP Davenport, SJ Kent, JA Juno, DS Khoury

2023-07-01

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) breakthrough infection of vaccinated individuals is increasingly comm..

Robust SARS-CoV-2 T cell responses with common TCRαβ motifs toward COVID-19 vaccines in patients with hematological malignancy impacting B cells

THO Nguyen, LC Rowntree, LF Allen, BY Chua, L Kedzierski, C Lim, M Lasica, GS Tennakoon, NR Saunders, M Crane, L Chee, JF Seymour, MA Anderson, A Whitechurch, EB Clemens, W Zhang, SY Chang, JR Habel, X Jia, HA McQuilten

2023-04-18

Immunocompromised hematology patients are vulnerable to severe COVID-19 and respond poorly to vaccination. Relative deficits in im..

SARS-CoV-2 breakthrough infection induces rapid memory and de novo T cell responses

M Koutsakos, A Reynaldi, WS Lee, J Nguyen, T Amarasena, G Taiaroa, P Kinsella, KC Liew, T Tran, HE Kent, HX Tan, LC Rowntree, THO Nguyen, PG Thomas, K Kedzierska, J Petersen, J Rossjohn, DA Williamson, D Khoury, MP Davenport

2023-04-11

Although the protective role of neutralizing antibodies against COVID-19 is well established, questions remain about the relative ..

Robust immunity to influenza vaccination in haematopoietic stem cell transplant recipients following reconstitution of humoral and adaptive immunity

W Zhang, LC Rowntree, R Muttucumaru, T Damelang, M Aban, AC Hurt, M Auladell, R Esterbauer, B Wines, M Hogarth, SJ Turner, AK Wheatley, SJ Kent, S Patil, S Avery, O Morrissey, AW Chung, M Koutsakos, THO Nguyen, AC Cheng

2023-01-01

Objectives: Influenza causes significant morbidity and mortality, especially in high-risk populations. Although current vaccinatio..

SARS-CoV-2-specific T cell memory with common TCRαβ motifs is established in unvaccinated children who seroconvert after infection

LC Rowntree, THO Nguyen, L Kedzierski, MR Neeland, J Petersen, JC Crawford, LF Allen, EB Clemens, B Chua, HA McQuilten, AA Minervina, MV Pogorelyy, P Chaurasia, HX Tan, AK Wheatley, X Jia, F Amanat, F Krammer, EK Allen, S Sonda

2022-07-12

As the establishment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific T cell memory in children remains la..

The magnitude and timing of recalled immunity after breakthrough infection is shaped by SARS-CoV-2 variants

M Koutsakos, WS Lee, A Reynaldi, HX Tan, G Gare, P Kinsella, KC Liew, G Taiaroa, DA Williamson, HE Kent, E Stadler, D Cromer, DS Khoury, AK Wheatley, JA Juno, MP Davenport, SJ Kent

2022-07-12

Vaccination against SARS-CoV-2 protects from infection and improves clinical outcomes in breakthrough infections, likely reflectin..

Cutting Edge: SARS-CoV-2 Infection Induces Robust Germinal Center Activity in the Human Tonsil

HX Tan, KM Wragg, HG Kelly, R Esterbauer, BJ Dixon, JSY Lau, KL Flanagan, CE van de Sandt, K Kedzierska, JH McMahon, AK Wheatley, JA Juno, SJ Kent

2022-05-15

Understanding the generation of immunity to SARSCoV- 2 in lymphoid tissues draining the site of infection has implications for imm..

Lung-resident memory B cells established after pulmonary influenza infection display distinct transcriptional and phenotypic profiles

HX Tan, JA Juno, R Esterbauer, HG Kelly, KM Wragg, P Konstandopoulos, S Alcantara, C Alvarado, R Jones, G Starkey, BZ Wang, O Yoshino, T Tiang, M Lindsay Grayson, H Opdam, R D'Costa, A Vago, LK Mackay, CL Gordon, D Masopust

2022-01-01

Recent studies have established that memory B cells, largely thought to be circulatory in the blood, can take up long-term residen..

Evolution of immune responses to SARS-CoV-2 in mild-moderate COVID-19

AK Wheatley, JA Juno, JJ Wang, KJ Selva, A Reynaldi, HX Tan, WS Lee, KM Wragg, HG Kelly, R Esterbauer, SK Davis, HE Kent, FL Mordant, TE Schlub, DL Gordon, DS Khoury, K Subbarao, D Cromer, TP Gordon, AW Chung

2021-12-01

The durability of infection-induced SARS-CoV-2 immunity has major implications for reinfection and vaccine development. Here, we s..

Immunogenicity of prime-boost protein subunit vaccine strategies against SARS-CoV-2 in mice and macaques

HX Tan, JA Juno, WS Lee, I Barber-Axthelm, HG Kelly, KM Wragg, R Esterbauer, T Amarasena, FL Mordant, K Subbarao, SJ Kent, AK Wheatley

2021-12-01

SARS-CoV-2 vaccines are advancing into human clinical trials, with emphasis on eliciting high titres of neutralising antibodies ag..

Robust and prototypical immune responses toward influenza vaccines in the high-risk group of Indigenous Australians

L Hensen, THO Nguyen, LC Rowntree, T Damelang, M Koutsakos, M Aban, A Hurt, KL Harland, M Auladell, CE van de Sandt, A Everitt, C Blacker, DA Oyong, JR Loughland, JR Webb, BD Wines, P Mark Hogarth, KL Flanagan, M Plebanski, A Wheatley

2021-10-12

Morbidity and mortality rates from seasonal and pandemic influenza occur disproportionately in high-risk groups, including Indigen..

SARS-CoV-2-specific CD8 T-cell responses and TCR signatures in the context of a prominent HLA-A*24:02 allomorph

LC Rowntree, J Petersen, JA Juno, P Chaurasia, K Wragg, M Koutsakos, L Hensen, AK Wheatley, SJ Kent, J Rossjohn, K Kedzierska, THO Nguyen

2021-10-01

In-depth understanding of human T-cell-mediated immunity in coronavirus disease 2019 (COVID-19) is needed if we are to optimize va..

Decay of Fc-dependent antibody functions after mild to moderate COVID-19

WS Lee, KJ Selva, SK Davis, BD Wines, A Reynaldi, R Esterbauer, HG Kelly, ER Haycroft, HX Tan, JA Juno, AK Wheatley, PM Hogarth, D Cromer, MP Davenport, AW Chung, SJ Kent

2021-06-15

The capacity of antibodies to engage with immune cells via the Fc region is important in preventing and controlling many infectiou..

Prospects for durable immune control of SARS-CoV-2 and prevention of reinfection

D Cromer, JA Juno, D Khoury, A Reynaldi, AK Wheatley, SJ Kent, MP Davenport

2021-06-01

Immunity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is central to long-term control of the current ..

CD8 T cells specific for an immunodominant SARS-CoV-2 nucleocapsid epitope display high naive precursor frequency and TCR promiscuity

THO Nguyen, LC Rowntree, J Petersen, BY Chua, L Hensen, L Kedzierski, CE van de Sandt, P Chaurasia, HX Tan, JR Habel, W Zhang, LF Allen, L Earnest, KY Mak, JA Juno, K Wragg, FL Mordant, F Amanat, F Krammer, NA Mifsud

2021-05-11

To better understand primary and recall T cell responses during coronavirus disease 2019 (COVID-19), it is important to examine un..

Integrated immune dynamics define correlates of COVID-19 severity and antibody responses

M Koutsakos, LC Rowntree, L Hensen, BY Chua, CE van de Sandt, JR Habel, W Zhang, X Jia, L Kedzierski, TM Ashhurst, GH Putri, F Marsh-Wakefield, MN Read, DN Edwards, EB Clemens, CY Wong, FL Mordant, JA Juno, F Amanat, J Audsley

2021-03-16

SARS-CoV-2 causes a spectrum of COVID-19 disease, the immunological basis of which remains ill defined. We analyzed 85 SARS-CoV-2-..

Antibody-dependent enhancement and SARS-CoV-2 vaccines and therapies

WS Lee, AK Wheatley, SJ Kent, BJ DeKosky

2020-10-01

Antibody-based drugs and vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are being expedited through..

Suboptimal SARS-CoV-2−specific CD8 T cell response associated with the prominent HLA-A*02:01 phenotype

JR Habel, THO Nguyen, CE van de Sandt, JA Juno, P Chaurasia, K Wragg, M Koutsakos, L Hensen, X Jia, B Chua, W Zhang, HX Tan, KL Flanagan, DL Doolan, J Torresi, W Chen, LM Wakim, AC Cheng, PC Doherty, J Petersen

2020-09-29

An improved understanding of human T cell-mediated immunity in COVID-19 is important for optimizing therapeutic and vaccine strate..

Humoral and circulating follicular helper T cell responses in recovered patients with COVID-19

JA Juno, HX Tan, WS Lee, A Reynaldi, HG Kelly, K Wragg, R Esterbauer, HE Kent, CJ Batten, FL Mordant, NA Gherardin, P Pymm, MH Dietrich, NE Scott, WH Tham, DI Godfrey, K Subbarao, MP Davenport, SJ Kent, AK Wheatley

2020-09-01

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has dramatically expedited global vaccine development ef..

Need for Speed: From Human SARS-CoV-2 Samples to Protective and Efficacious Antibodies in Weeks

MG Joyce, AK Wheatley, K Modjarrad

2020-07-09

The emergence of SARS-CoV-2 has driven a global research effort to identify medical countermeasures at an unprecedented pace. In t..

Self-assembling influenza nanoparticle vaccines drive extended germinal center activity and memory B cell maturation.

Hannah G Kelly, Hyon-Xhi Tan, Jennifer A Juno, Robyn Esterbauer, Yi Ju, Wenbo Jiang, Verena C Wimmer, Brigette C Duckworth, Joanna R Groom, Frank Caruso, Masaru Kanekiyo, Stephen J Kent, Adam K Wheatley

2020-05-21

Protein-based, self-assembling nanoparticles elicit superior immunity compared with soluble protein vaccines, but the immune mecha..