ROLE OF THE ENTERIC NERVOUS SYSTEM IN ANTIBIOTIC ASSOCIATED DIARRHOEA
Grant number: 1158952 | Funding period: 2019 - 2022
This project will identify the role played by the gut's own nervous system in the diarrhoea that is often associated with antibiotic treatment. This type of diarrhoea is common in hospitals and can be fatal if not adequately treated. Understanding the role of the nervous system in this disease process and the changes in nervous system function once diarrhoea is established will point to specific treatments and means of prevention to reduce negative side effects of antibiotic treatment.
Related publications (9)
Group I Metabotropic Glutamate Receptors Modulate Motility and Enteric Neural Activity in the Mouse Colon
Anita JL Leembruggen, Yuqing Lu, Haozhe Wang, Volkan Uzungil, Thibault Renoir, Anthony JJ Hannan, Lincon AA Stamp, Marlene MM Hao, Joel CC Bornstein
Glutamate is the major excitatory neurotransmitter in the central nervous system, and there is evidence that Group-I metabotropic ..
Oxidative Stress-Induced HMGB1 Translocation in Myenteric Neurons Contributes to Neuropathy in Colitis
Rhian Stavely, Lauren Sahakian, Rhiannon TT Filippone, Vanesa Stojanovska, Joel CC Bornstein, Samy Sakkal, Kulmira Nurgali
High-mobility group box 1 (HMGB1) is a damage-associated molecular pattern released by dying cells to stimulate the immune respons..
Potent CCR3 Receptor Antagonist, SB328437, Suppresses Colonic Eosinophil Chemotaxis and Inflammation in the Winnie Murine Model of Spontaneous Chronic Colitis
Rhiannon T Filippone, Narges Dargahi, Rajaraman Eri, Jose A Uranga, Joel C Bornstein, Vasso Apostolopoulos, Kulmira Nurgali
Eosinophils and their regulatory molecules have been associated with chronic intestinal inflammation and gastrointestinal dysfunct..
Computational simulations and Ca2 imaging reveal that slow synaptic depolarizations (slow EPSPs) inhibit fast EPSP evoked action potentials for most of their time course in enteric neurons
Parvin Zarei Eskikand, Katerina Koussoulas, Rachel M Gwynne, Joel C Bornstein
Transmission between neurons in the extensive enteric neural networks of the gut involves synaptic potentials with vastly differen..
Divergent Adaptations in Autonomic Nerve Activity and Neuroimmune Signaling Associated With the Severity of Inflammation in Chronic Colitis
Rhian Stavely, Ahmed A Rahman, Lauren Sahakian, Monica D Prakash, Ainsley M Robinson, Majid Hassanzadeganroudsari, Rhiannon T Filippone, Sarah Fraser, Rajaraman Eri, Joel C Bornstein, Vasso Apostolopoulos, Kulmira Nurgali
BACKGROUND: The autonomic nervous system (ANS) is thought to play a critical role in the anti-inflammatory reflex pathway in acute..
Neuroinflammation as an etiological trigger for depression comorbid with inflammatory bowel disease
Colin F Craig, Rhiannon T Filippone, Rhian Stavely, Joel C Bornstein, Vasso Apostolopoulos, Kulmira Nurgali
Patients with inflammatory bowel disease (IBD) suffer from depression at higher rates than the general population. An etiological ..
The Role of the Gastrointestinal Mucus System in Intestinal Homeostasis: Implications for Neurological Disorders
Madushani Herath, Suzanne Hosie, Joel C Bornstein, Ashley E Franks, Elisa L Hill-Yardin
Mucus is integral to gut health and its properties may be affected in neurological disease. Mucus comprises a hydrated network of ..