MINIMALLY INVASIVE ENDOVASCULAR NEURAL STIMULATION
Grant number: 1158912 | Funding period: 2019 - 2022
Neural deficits such as Parkinson’s disease can be helped by electrically stimulating the brain to activate neurons. Current implants require an invasive craniotomy, where a hole is cut in the skull and electrodes are implanted in the brain, causing permanent damage. We have designed a new way to implant electrodes through blood vessels and a simple puncture into the jugular vein that removes the need for a craniotomy. We will test the efficacy of this device in stimulating neurons.
Related publications (19)
Focal stimulation of the sheep motor cortex with a chronically implanted minimally invasive electrode array mounted on an endovascular stent
Nicholas L Opie, Sam E John, Gil S Rind, Stephen M Ronayne, Yan T Wong, Giulia Gerboni, Peter E Yoo, Timothyj H Lovell, Theodore CM Scordas, Stefan L Wilson, Anthony Dornom, Thomas Vale, Terence J O'brien, David B Grayden, Clive N May, Thomasj Oxley
Optimized partial-coverage functional analysis pipeline (OPFAP): a semi-automated pipeline for skull stripping and co-registration of partial-coverage, ultra-high-field functional images
Peter E Yoo, Jon O Cleary, Scott C Kolbe, Roger J Ordidge, Terence J O'Brien, Nicholas L Opie, Sam E John, Thomas J Oxley, Bradford A Moffat
Effect of Implant Duration, Anatomical Location and Electrode Orientation on Bandwidth Recorded with a Chronically Implanted Endovascular Stent-Electrode Array.
Nicholas L Opie, Sam E John, Gil S Rind, Stephen M Ronayne, Clive N May, David B Grayden, Thomas J Oxley
Access to the brain to implant recording electrodes has conventionally required a craniotomy. To mitigate risks of open brain surg..
An ovine model of cerebral catheter venography for implantation of an endovascular neural interface
Thomas James Oxley, Nicholas Lachlan Opie, Gil Simon Rind, Kishan Liyanage, Sam Emmanuel John, Stephen Ronayne, Alan James McDonald, Anthony Dornom, Timothy John Haynes Lovell, Peter John Mitchell, Iwan Bennett, Sebastien Bauquier, Leon Norris Warne, Chris Steward, David Bruce Grayden, Patricia Desmond, Stephen M Davis, Terence John O'Brien, Clive N May
7T-fMRI: Faster temporal resolution yields optimal BOLD sensitivity for functional network imaging specifically at high spatial resolution
Peter E Yoo, Sam E John, Shawna Farquharson, Jon O Cleary, Yan T Wong, Amanda Ng, Claire B Mulcahy, David B Grayden, Roger J Ordidge, Nicholas L Opie, Terence J O'Brien, Thomas J Oxley, Bradford A Moffat