CAN WE BUILD A GENETIC TRAP FOR DRUG RESISTANT MALARIA PARASITES?

Abstract

Malaria is a major global health issue. Drugs are key weapons against malaria, but resistance typically emerges and spreads, rendering a succession of drugs useless. We recently identified a safe and cheap drug for which the spread of resistance is severely constrained. We propose to identify more such resistance-proof drugs that can be used in combination with other drugs to better manage the spread of resistance and better control disease.

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