CAN WE BUILD A GENETIC TRAP FOR DRUG RESISTANT MALARIA PARASITES?
Grant number: 1162550 | Funding period: 2019 - 2021
Malaria is a major global health issue. Drugs are key weapons against malaria, but resistance typically emerges and spreads, rendering a succession of drugs useless. We recently identified a safe and cheap drug for which the spread of resistance is severely constrained. We propose to identify more such resistance-proof drugs that can be used in combination with other drugs to better manage the spread of resistance and better control disease.
Related publications (1)
A single point mutation in the Plasmodium falciparum FtsH1 metalloprotease confers actinonin resistance
Christopher D Goodman, Taher Uddin, Natalie J Spillman, Geoffrey McFadden
The antibiotic actinonin kills malaria parasites (Plasmodium falciparum) by interfering with apicoplast function. Early evidence s..