TRANEXAMIC ACID AND HYPOTENSION-AVOIDANCE TO PREVENT DEATH AND MAJOR COMPLICATIONS AFTER NONCARDIAC SURGERY (PERIOPERATIVE ISCHEMIC EVALUATION-3 – THE POISE-3 TRIAL)

Grant number: 1162362 | Funding period: 2019 - 2023

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Abstract

Bleeding and low blood pressure are common and dangerous complications of anaesthesia and surgery. We propose a large international study to determine if tranexamic acid (TXA) is a safe and efficacious drug to prevent bleeding, and whether preventing low blood pressure is efficacious in reducing death and major complications after surgery in older sicker patients having major noncardiac surgery. This study has the potential to improve clinical outcomes for millions of patients worldwide