CHARACTERISING MECHANISMS THAT UNDERPIN DRUG TOLERANCE AND TREATMENT RESISTANCE IN COLORECTAL CANCER METASTASES.
Grant number: 1164081 | Funding period: 2019 - 2022
Related publications (9)
The site of breast cancer metastases dictates their clonal composition and reversible transcriptomic profile
Jean Berthelet, Verena C Wimmer, Holly J Whitfield, Antonin Serrano, Thomas Boudier, Stefano Mangiola, Michal Merdas, Farrah El-Saafin, David Baloyan, Jordan Wilcox, Steven Wilcox, Adam C Parslow, Anthony T Papenfuss, Belinda Yeo, Matthias Ernst, Bhupinder Pal, Robin L Anderson, Melissa J Davis, Kelly L Rogers, Frederic Hollande
Intratumoral heterogeneity is a driver of breast cancer progression, but the nature of the clonal interactive network involved in ..
Progastrin production transitions from Bmi1( )/Prox1( ) to Lgr5(high) cells during early intestinal tumorigenesis
J Giraud, M Foroutan, J Boubaker-Vitre, F Grillet, Z Homayed, U Jadhav, P Crespy, C Breuker, J-F Bourgaux, J Hazerbroucq, C Pignodel, B Brulin, RA Shivdasani, P Jay, F Hollande, J Pannequin
Progastrin is an unprocessed soluble peptide precursor with a well-described tumor-promoting role in colorectal cancer. It is expr..
A thiol-bound drug reservoir enhances APR-246-induced mutant p53 tumor cell death
Sophia Ceder, Sofi E Eriksson, Emarndeena H Cheteh, Swati Dawar, Mariana Corrales Benitez, Vladimir JN Bykov, Kenji M Fujihara, Melodie Grandin, Xiaodun Li, Susanne Ramm, Corina Behrenbruch, Kaylene J Simpson, Frederic Hollande, Lars Abrahmsen, Nicholas J Clemons, Klas G Wiman
The tumor suppressor gene TP53 is the most frequently mutated gene in cancer. The compound APR-246 (PRIMA-1Met/Eprenetapopt) is co..
A Gene Signature Predicting Natural Killer Cell Infiltration and Improved Survival in Melanoma Patients
Joseph Cursons, Fernando Souza-Fonseca-Guimaraes, Momeneh Foroutan, Ashley Anderson, Frederic HoHande, Soroor Hediyeh-Zadeh, Andreas Behren, Nicholas D Huntington, Melissa J Davis
Natural killer (NK) cell activity is essential for initiating antitumor responses and may be linked to immunotherapy success. NK c..
A Spatio-Temporal Model and Inference Tools for Longitudinal Count Data on Multicolor Cell Growth
PuXue Qiao, Christina Molck, Davide Ferrari, Frederic Hollande
Multicolor cell spatio-temporal image data have become important to investigate organ development and regeneration, malignant grow..
Surgical stress response and promotion of metastasis in colorectal cancer: a complex and heterogeneous process
Corina Behrenbruch, Carolyn Shembrey, Sophie Paquet-Fifield, Christina Molck, Hyun-Jung Cho, Michael Michael, Benjamin NJ Thomson, Alexander G Heriot, Frederic Hollande
Surgery remains the curative treatment modality for colorectal cancer in all stages, including stage IV with resectable liver meta..