CHARACTERISING MECHANISMS THAT UNDERPIN DRUG TOLERANCE AND TREATMENT RESISTANCE IN COLORECTAL CANCER METASTASES.

Dependence receptors: new targets for cancer therapy

Morgan Brisset, Melodie Grandin, Agnes Bernet, Patrick Mehlen, Frederic Hollande

2021-09-20

Dependence receptors are known to promote survival and positive signaling such as proliferation, migration, and differentiation wh..

The site of breast cancer metastases dictates their clonal composition and reversible transcriptomic profile

Jean Berthelet, Verena C Wimmer, Holly J Whitfield, Antonin Serrano, Thomas Boudier, Stefano Mangiola, Michal Merdas, Farrah El-Saafin, David Baloyan, Jordan Wilcox, Steven Wilcox, Adam C Parslow, Anthony T Papenfuss, Belinda Yeo, Matthias Ernst, Bhupinder Pal, Robin L Anderson, Melissa J Davis, Kelly L Rogers, Frederic Hollande

2021-07-01

Intratumoral heterogeneity is a driver of breast cancer progression, but the nature of the clonal interactive network involved in ..

Progastrin production transitions from Bmi1( )/Prox1( ) to Lgr5(high) cells during early intestinal tumorigenesis

J Giraud, M Foroutan, J Boubaker-Vitre, F Grillet, Z Homayed, U Jadhav, P Crespy, C Breuker, J-F Bourgaux, J Hazerbroucq, C Pignodel, B Brulin, RA Shivdasani, P Jay, F Hollande, J Pannequin

2021-02-01

Progastrin is an unprocessed soluble peptide precursor with a well-described tumor-promoting role in colorectal cancer. It is expr..

A thiol-bound drug reservoir enhances APR-246-induced mutant p53 tumor cell death

Sophia Ceder, Sofi E Eriksson, Emarndeena H Cheteh, Swati Dawar, Mariana Corrales Benitez, Vladimir JN Bykov, Kenji M Fujihara, Melodie Grandin, Xiaodun Li, Susanne Ramm, Corina Behrenbruch, Kaylene J Simpson, Frederic Hollande, Lars Abrahmsen, Nicholas J Clemons, Klas G Wiman

2020-12-14

The tumor suppressor gene TP53 is the most frequently mutated gene in cancer. The compound APR-246 (PRIMA-1Met/Eprenetapopt) is co..

Impact of Tumor and Immunological Heterogeneity on the Anti-Cancer Immune Response

Carolyn Shembrey, Nicholas D Huntington, Frederic Hollande

2019-09-01

Metastatic tumors are the primary cause of cancer-related mortality. In recent years, interest in the immunologic control of malig..

A Gene Signature Predicting Natural Killer Cell Infiltration and Improved Survival in Melanoma Patients

Joseph Cursons, Fernando Souza-Fonseca-Guimaraes, Momeneh Foroutan, Ashley Anderson, Frederic HoHande, Soroor Hediyeh-Zadeh, Andreas Behren, Nicholas D Huntington, Melissa J Davis

2019-07-01

Natural killer (NK) cell activity is essential for initiating antitumor responses and may be linked to immunotherapy success. NK c..

A Spatio-Temporal Model and Inference Tools for Longitudinal Count Data on Multicolor Cell Growth

PuXue Qiao, Christina Molck, Davide Ferrari, Frederic Hollande

2018-11-01

Multicolor cell spatio-temporal image data have become important to investigate organ development and regeneration, malignant grow..

Optical barcoding highlights novel characteristics of treatment resistant cells in metastatic colorectal cancer

Frederic Hollande, Corina Behrenbruch, Carolyn Shembrey, Pu Xue Qiao, Davide Ferrari, Benjamin Thomson, Michael Michael, Alexander Heriot

2018-11-01

Surgical stress response and promotion of metastasis in colorectal cancer: a complex and heterogeneous process

Corina Behrenbruch, Carolyn Shembrey, Sophie Paquet-Fifield, Christina Molck, Hyun-Jung Cho, Michael Michael, Benjamin NJ Thomson, Alexander G Heriot, Frederic Hollande

2018-04-01

Surgery remains the curative treatment modality for colorectal cancer in all stages, including stage IV with resectable liver meta..