TARGETING NUCLEOLAR DNA DAMAGE RESPONSE AS A NOVEL THERAPEUTIC STRATEGY FOR HIGH GRADE SEROUS OVARIAN CANCER
Grant number: 1162052 | Funding period: 2019 - 2022
This grant will provide supplemental funding to the fall 2012 Thematic Program on Forcing and its Applications at the Fields Institute in Toronto, Ontario. Fifty years ago Paul Cohen developed the method of forcing to solve Hilbert's first problem: the truth of the Continuum Hypothesis. Today this method is more relevant than ever. While it was originally developed as a meta-mathematical tool, it has been also used to solve problems arising in combinatorics, functional analysis, and topology. As the method matured and became even more powerful, its scope and reach has been significantly broadened. New directions in forcing are ever more influenced by fundamental questions in a broadening ran..View full description
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Hyperactivation of RNA polymerase I (Pol I) transcription of ribosomal RNA (rRNA) genes (rDNA) is a key determinant of growth and ..
CX-5461 activates the DNA damage response and demonstrates therapeutic efficacy in high-grade serous ovarian cancer
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Acquired resistance to PARP inhibitors (PARPi) is a major challenge for the clinical management of high grade serous ovarian cance..