THE METASTABILITY OF PROTEOME FOLDEDNESS IN NEURODEGENERATIVE DISEASE

Abstract

The research objective of this award is to develop a quantitative and mechanistic understanding of how the genomic material of viruses enters the cells they are infecting. Cells across all domains of life are subjected to infection by viruses. These viruses have a multitude of different lifestyles which often involve different ways of introducing their genes into the infected host. For some of these viruses, it has been hypothesized that mechanical forces resulting from the tightly-packaged DNA within the virus creates a pressure which injects the DNA into the host?s interior. Studies conducted under this award will test this hypothesis by using fluorescence microscopy to watch individual vi..