DEFINING THE ANTEROGRADE AND ENDOCYTIC TRAFFICKING PATHWAYS IN PRIMARY NEURONS; RELEVANCE TO DYSFUNCTIONAL TRAFFICKING OF BACE1 AND APP IN ALZHEIMER’S DISEASE

Amyloid beta production along the neuronal secretory pathway: Dangerous liaisons in the Golgi?

Lou Fourriere, Paul A Gleeson

2021-07-11

β-amyloid peptides (Aβ) are generated in intracellular compartments of neurons and secreted to form cytotoxic fibrils and plaques...

Sorting nexin 5 mediates virus-induced autophagy and immunity

Xiaonan Dong, Yuting Yang, Zhongju Zou, Yuting Zhao, Bo Ci, Lin Zhong, Madhura Bhave, Liwei Wang, Yi-Chun Kuo, Xiao Zang, Rui Zhong, Elizabeth R Aguilera, R Blake Richardson, Boris Simonetti, John W Schoggins, Julie K Pfeiffer, Li Yu, Xuewu Zhang, Yang Xie, Sandra L Schmid

2021-01-21

Autophagy, a process of degradation that occurs via the lysosomal pathway, has an essential role in multiple aspects of immunity, ..

Distinct anterograde trafficking pathways of BACE1 and amyloid precursor protein from the TGN and the regulation of amyloid-beta production

Jing Zhi A Tan, Lou Fourriere, Jingqi Wang, Franck Perez, Gaelle Boncompain, Paul A Gleeson

2020-01-01

Processing of amyloid precursor protein (APP) by the β-secretase BACE1 is the initial step of the amyloidogenic pathway to generat..

The role of innate immune responses and neuroinflammation in amyloid accumulation and progression of Alzheimer's disease

Alessandra Webers, Michael T Heneka, Paul A Gleeson

2019-11-20

Alzheimer's disease (AD) is characterized by amyloid beta (Aβ) accumulation, tau pathology and neuroinflammation. Recently, there ..